Etiologic variability of nephropathy in juvenile diabetes mellitus.

Abstract:

:Clinicopathologic studies of four patients with juvenile diabetes mellitus and renal disease demonstrated the pathogenetic variability of nephropathy in diabetic patients. Only in one patient was the clinical nephropathy associated with the typical diabetic glomerulosclerosis. Another patient had steroid responsive nephrotic syndrome superimposed on minimal diabetic glomerulosclerosis. A third patient had steroid resistant nephrotic syndrome associated with mild diabetic glomerulosclerosis and with later appearance of Grave's disease. The fourth patient, in addition to moderate diabetic glomerulosclerosis had prominent tubulointerstitial nephritis, the latter probably being responsible for the rapidly declining renal function. The poor prognosis associated with diabetic nephropathy warrants a careful search for other potentially treatable causes of nephropathy in patients with juvenile diabetes mellitus.

journal_name

Arch Pathol Lab Med

authors

Gilboa N,Durante D,McIntosh RM,Guggenheim S

subject

Has Abstract

pub_date

1979-08-01 00:00:00

pages

479-82

issue

9

eissn

0003-9985

issn

1543-2165

journal_volume

103

pub_type

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