Mixed ductal-endocrine carcinoma of the pancreas: a possible pathogenic mechanism for arrhythmogenic right ventricular cardiomyopathy.

Abstract:

:We describe herein a case of a mixed ductal-endocrine pancreatic carcinoma. Rare cases of mixed pancreatic tumors have been described, with endocrine and exocrine components each making up a significant proportion of the neoplasm; to our knowledge, only one case has been reported with a mixed liver metastasis. In our case, ductal and endocrine cells were intimately admixed in the primary tumor and in a peripancreatic lymph node metastasis, diagnosed by standard light microscopy and double immunostaining for cytokeratin 19 and synaptophysin. The endocrine component was immunoreactive for somatostatin. Tumors with admixed endocrine and exocrine components support the hypothesis of a common endodermal histogenesis for the ductal and endocrine cells in the human pancreas.

journal_name

Arch Pathol Lab Med

authors

Leteurtre E,Brami F,Kerr-Conte J,Quandalle P,Lecomte-Houcke M

doi

10.1043/0003-9985(2000)124<0284:MDECOT>2.0.CO;2

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

284-6

issue

2

eissn

0003-9985

issn

1543-2165

journal_volume

124

pub_type

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