Abstract:
:We describe herein a case of a mixed ductal-endocrine pancreatic carcinoma. Rare cases of mixed pancreatic tumors have been described, with endocrine and exocrine components each making up a significant proportion of the neoplasm; to our knowledge, only one case has been reported with a mixed liver metastasis. In our case, ductal and endocrine cells were intimately admixed in the primary tumor and in a peripancreatic lymph node metastasis, diagnosed by standard light microscopy and double immunostaining for cytokeratin 19 and synaptophysin. The endocrine component was immunoreactive for somatostatin. Tumors with admixed endocrine and exocrine components support the hypothesis of a common endodermal histogenesis for the ductal and endocrine cells in the human pancreas.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Leteurtre E,Brami F,Kerr-Conte J,Quandalle P,Lecomte-Houcke Mdoi
10.1043/0003-9985(2000)124<0284:MDECOT>2.0.CO;2subject
Has Abstractpub_date
2000-02-01 00:00:00pages
284-6issue
2eissn
0003-9985issn
1543-2165journal_volume
124pub_type
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