Abstract:
CONTEXT:Childhood mortality statistics are based on death certificates. The causes of death listed on death certificates may not be confirmed by autopsy findings, and mortality statistics may reflect deaths of many children with chronic disease. The diseases responsible for nontraumatic deaths of previously healthy children cannot be determined from these statistics. OBJECTIVE:To identify causes of nontraumatic death in previously healthy or near-healthy children presenting to a children's hospital. DESIGN:Retrospective review of autopsy protocols from 572 children who died at Children's Hospital of New Orleans in Louisiana between 1985 and 2003, with the premise that autopsy was done after most deaths of previously healthy or near-healthy children. Causes of death were grouped by disease processes and age groups and were compared to premortem clinical diagnoses. RESULTS:Eighty-eight autopsy protocols were from children who were previously healthy or near healthy before the hospital admission during which they died. The median age was 11.4 months and the median length of stay was 2 days. Infection, primarily of the central nervous system and systemic (septicemia), was the most common cause of death (53%, 47 cases). Neoplasia, primarily of the central nervous and hematologic systems, was the second most common cause (15%, 13 cases). The predominant organ system involved with disease was the nervous system (36%, 32 cases). Unrecognized congenital disorders were found in approximately 10% of the cases. CONCLUSIONS:Infectious diseases are a frequent cause of death in previously healthy children. Fatal diseases most frequently affect the nervous system. Autopsy provides valuable information in the death of healthy children.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Taggart MW,Craver Rdoi
10.1043/1543-2165(2006)130[1780:CODDBA]2.0.CO;2subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1780-5issue
12eissn
0003-9985issn
1543-2165pii
OA-0021journal_volume
130pub_type
杂志文章abstract:CONTEXT:Pediatric myelodysplastic syndromes (MDSs) are uncommon disorders, which may be difficult to diagnose, particularly in the absence of increased blasts. Pediatric MDSs have several unique features including their association with inherited/constitutional disorders in approximately one third of patients. The clas...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:10.1043/1543-2165(2007)131[1110:MSICAC]2.0.CO;2
更新日期:2007-07-01 00:00:00
abstract::The concentration of neuron-specific enolase (NSE, gamma-subunit of enolase) in tumor extracts of 25 nonargyrophilic and seven argyrophilic carcinomas of the female breast was measured by radioimmunoassay. The mean concentration of NSE in nonargyrophilic carcinomas was 89 ng/mg of protein, (range, 9 to 281 ng/mg), and...
journal_title:Archives of pathology & laboratory medicine
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doi:
更新日期:1987-09-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
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abstract::Because of the difficulty in identifying silicone gel in histologic and cytologic specimens by means of conventional light microscopy, we investigated alternative light microscopy techniques, as well as specimen staining and preparation. Specimens from six periprosthetic capsules, one silicone granuloma specimen, and ...
journal_title:Archives of pathology & laboratory medicine
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更新日期:1994-10-01 00:00:00
abstract::Using the formaldehyde-induced fluorescence method, we found a peculiar rosary-type swelling of the adrenergic axons in the peripheral nerves, deficiency of the perivascular adrenergic plexuses in the visceral and cerebral arteries, and reduction of noradrenergic fluorescence in the tegmental and hypothalamic regions ...
journal_title:Archives of pathology & laboratory medicine
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更新日期:1983-06-01 00:00:00
abstract::Desmoplastic small round cell tumor typically presents with abundant desmoplastic stroma containing nested primitive round cells bearing a polyphenotypic immunohistochemical profile. Lesions with minimal classic morphology pose a formidable diagnostic challenge. The current case represents one such example, arising as...
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更新日期:2007-04-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::I report a case of peripheral bronchial carcinoid tumor composed of bundles of large spindle cells, very much resembling cells of smooth muscle or neural tumors. Despite the unusual appearance, argyrophil staining and electron microscopic examination demonstrated small secretory granules of the type found in other per...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::The epidermal growth factor receptor (EGFr) is a membrane-bound glycoprotein that is present in a wide variety of human normal and malignant tissues. In this study EGFr expression in frozen sections of prostate tissue obtained from 40 different surgical specimens was examined immunohistochemically with a well-characte...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:10.1043/2009-0579-RAR1.1
更新日期:2010-11-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/1543-2165-132.12.1916
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1979-08-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:10.1043/0003-9985(1999)123<0889:P>2.0.CO;2
更新日期:1999-10-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.5858/arpa.2014-0453-OA
更新日期:2016-01-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
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更新日期:2013-09-01 00:00:00
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更新日期:2005-08-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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更新日期:2001-10-01 00:00:00
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更新日期:2012-07-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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doi:10.1043/1543-2165(2007)131[112:AOACPF]2.0.CO;2
更新日期:2007-01-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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doi:
更新日期:1996-05-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2007-05-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1983-12-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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doi:
更新日期:1986-11-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00