Parvovirus B19 infection in the immunocompromised host.

Abstract:

:Human parvovirus B19 is a single-stranded DNA virus with a predilection for infecting rapidly dividing cell lines, such as bone marrow erythroid progenitor cells. People with defective cell-mediated immunity (eg, severe combined immunodeficiency syndrome; acquired immunodeficiency syndrome; and patients receiving immunosuppressive therapy, ie, post organ transplant) can develop pure red cell aplasia, in which suppression of erythroid precursors is permanent. Identification of parvovirus inclusions in marrow biopsies and subsequent confirmation of infection by in situ hybridization is important in the assessment of anemia in immunodeficient patients. Our objective is to provide a general overview of the parvovirus B19 infection and its characteristics in immunocompromised patients and to summarize updated information regarding the clinicopathologic features, pathobiology, and laboratory diagnosis of this subject. The pathologist should be aware of the wide spectrum of manifestations of parvovirus B19 infection depending on the patient's hematologic and immunologic status.

journal_name

Arch Pathol Lab Med

authors

Florea AV,Ionescu DN,Melhem MF

doi

10.1043/1543-2165(2007)131[799:PBIITI]2.0.CO;2

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

799-804

issue

5

eissn

0003-9985

issn

1543-2165

pii

RS6-0479

journal_volume

131

pub_type

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