An overview of inflicted head injury in infants and young children, with a review of beta-amyloid precursor protein immunohistochemistry.

Abstract:

CONTEXT:Inflicted traumatic brain injury of infants and young children results in a complex array of autopsy findings. In many cases, immunostains for beta-amyloid precursor protein are used to detect axonal injury. Interpretation of the gross, microscopic, and immunostaining results requires the integration of the many facets of the individual case. OBJECTIVE:In this article we review the gross and microscopic findings associated with inflicted traumatic brain injury. The application and interpretation of beta-amyloid precursor protein immunostains are discussed and photomicrographs are used to illustrate immunostaining patterns. DATA SOURCES:The pertinent literature is integrated into a review of the subject. CONCLUSIONS:Inflicted traumatic brain injury often results in subdural, subarachnoid, retinal, and optic nerve sheath hemorrhage. These findings must be interpreted within the entire context of the case. Beta-amyloid precursor protein immunostains may be helpful in illustrating the traumatic nature of the injuries in some cases.

journal_name

Arch Pathol Lab Med

authors

Dolinak D,Reichard R

doi

10.1043/1543-2165(2006)130[712:AOOIHI]2.0.CO;2

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

712-7

issue

5

eissn

0003-9985

issn

1543-2165

pii

RA5751

journal_volume

130

pub_type

杂志文章,评审
  • Adult rhabdomyoma: ultrastructure and immunocytochemistry.

    abstract::Adult rhabdomyoma is a benign, highly differentiated tumor of skeletal muscle. We observed transverse tubules and triads beside myofilaments in a rhabdomyoma from the submandibular area of a 66-year-old woman. Several types of muscle cells were present. In one, mitochondria abounded; in another, muscle filaments predo...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Warner TF,Goell W,Sundharadas M,Falk VS

    更新日期:1981-11-01 00:00:00

  • Trends in Cervical Cytology Screening and Reporting Practices: Results From the College of American Pathologists 2011 PAP Education Supplemental Questionnaire.

    abstract:CONTEXT:The College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey. OBJECTIVE:To provide a cross-sectional survey of gynecologic cytology practices in 2010. DESIGN:In 2011, a survey was sent to 160...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2015-0004-CP

    authors: Crothers BA,Darragh TM,Tambouret RH,Nayar R,Barkan GA,Zhao C,Booth CN,Padmanabhan V,Tabatabai ZL,Souers RJ,Thomas N,Wilbur DC,Moriarty AT

    更新日期:2016-01-01 00:00:00

  • Accuracy of fine-needle aspiration of thyroid.

    abstract:CONTEXT:Fine-needle aspiration has become an accepted and cost-effective procedure for rapid diagnosis of thyroid lesions. The routine use of fine-needle aspiration has reduced the rate of unnecessary surgery for thyroid nodules. OBJECTIVES:To determine the accuracy of fine-needle aspiration biopsy diagnosis and to di...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2001)125<0484:AOFNAO>2.0.CO;2

    authors: Amrikachi M,Ramzy I,Rubenfeld S,Wheeler TM

    更新日期:2001-04-01 00:00:00

  • Myelodysplastic syndromes in children: a critical review of issues in the diagnosis and classification of 887 cases from 13 published series.

    abstract:CONTEXT:Pediatric myelodysplastic syndromes (MDSs) are uncommon disorders, which may be difficult to diagnose, particularly in the absence of increased blasts. Pediatric MDSs have several unique features including their association with inherited/constitutional disorders in approximately one third of patients. The clas...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2007)131[1110:MSICAC]2.0.CO;2

    authors: Elghetany MT

    更新日期:2007-07-01 00:00:00

  • Molecular diagnostics of lung carcinomas.

    abstract:CONTEXT:The development of targeted therapies in the treatment of lung carcinoma is a rapidly growing area that requires a precise histologic classification of lung carcinomas and the implementation into clinical practice of testing for predictive biomarkers of therapy response. Molecular testing has added another laye...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/2010-0625-RAIR.1

    authors: Dacic S

    更新日期:2011-05-01 00:00:00

  • Coronary ostial stenosis complicating coronary arteriography.

    abstract::Coronary ostial stenosis is a cause of angina pectoris and sudden death. It is due mainly to atherosclerosis, syphilis, and iatrogenic disease. The last is of growing importance because of the frequency of coronary arteriography and surgical procedures on the aortic valve. Since both may cause stenosis of the coronary...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Knutson EL,Smith JC

    更新日期:1976-03-01 00:00:00

  • Solitary fibrous tumors in the central nervous system. A clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomas.

    abstract:CONTEXT:Solitary fibrous tumors (SFTs) of the central nervous system are rare neoplasms that usually present as dura-based masses and clinically resemble meningiomas. Histologically, they can be similar to fibrous meningioma or hemangiopericytoma (HPC). In particular, densely cellular regions seen in some SFTs can be i...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1043/0003-9985(2003)127<0432:SFTITC>2.0.CO;2

    authors: Tihan T,Viglione M,Rosenblum MK,Olivi A,Burger PC

    更新日期:2003-04-01 00:00:00

  • Intraosseous malignant peripheral nerve sheath tumor. Report of a case and review of the literature.

    abstract::We report a case of a malignant peripheral nerve sheath tumor arising in the distal femur of a 28-year-old man who had no stigmata of von Recklinghausen's disease. Roentgenograms and computed tomographic scans of the distal femur showed a single lytic intraosseous lesion with minimal soft tissue extension. Light micro...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Bullock MJ,Bedard YC,Bell RS,Kandel R

    更新日期:1995-04-01 00:00:00

  • A high-grade primary leiomyosarcoma of the bladder in a survivor of retinoblastoma.

    abstract::Second nonocular malignancies develop with increased incidence in patients with hereditary retinoblastoma. Osteosarcoma is by far the most common type with an incidence of up to 50%, followed by soft tissue sarcomas. Visceral leiomyosarcoma is extremely rare and only 2 cases have been reported in the past 2 decades, o...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2001)125<1231:AHGPLO>2.0.CO;2

    authors: Liang SX,Lakshmanan Y,Woda BA,Jiang Z

    更新日期:2001-09-01 00:00:00

  • Update on nonneoplastic pulmonary lymphoproliferative disorders and related entities.

    abstract:CONTEXT:Recent discoveries have expanded the spectrum of nonneoplastic pulmonary lymphoproliferative disorders and have provided new insights into their pathogenesis and treatment. OBJECTIVE:To review the thoracic manifestations of immunoglobulin (Ig) G4-related sclerosing disease and summarize current concepts and di...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165-134.5.691

    authors: Guinee DG Jr

    更新日期:2010-05-01 00:00:00

  • Human anti-mouse antibodies.

    abstract::Human anti-mouse antibodies (HAMA) are human immunoglobulins with specificity for mouse immunoglobulins. This topic currently is of interest because of the increased use of monoclonal mouse antibodies as diagnostic reagents both for in vitro laboratory measurements and for in vivo imaging studies. Monoclonal mouse ant...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/0003-9985(2000)124<0921:HAMA>2.0.CO;2

    authors: Klee GG

    更新日期:2000-06-01 00:00:00

  • Correlative study of microvessel density and 5-lipoxygenase expression in human sporadic colorectal cancer.

    abstract:CONTEXT:5-Lipoxygenase (5-LO) is an arachidonic acid- metabolizing enzyme, which has been demonstrated to exert a role in colorectal cancer tumorigenesis. Its activity in promoting neoangiogenesis in colorectal malignancies has been also recently theorized on the basis of in vitro studies. OBJECTIVE:To investigate whe...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165-132.11.1807

    authors: Barresi V,Vitarelli E,Tuccari G,Barresi G

    更新日期:2008-11-01 00:00:00

  • Sympodial monsters: two autopsy cases of sympus dipus.

    abstract::Two autopsy cases of sympodial monsters, sympus dipus, were studied. They are of interest not only because they show the characteristic malformations of the limbs and the viscera below the diaphragm, but because one case also shows Potter's face and an atrial septal defect of the heart. In addition, histologic determi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Nakamura Y,Komatsu Y,Nagasue N,Fukagawa K,Hamaguchi H,Akashi M

    更新日期:1981-10-01 00:00:00

  • Trends in Mortality From Human Immunodeficiency Virus Infection, 1984-2016: An Autopsy-Based Study.

    abstract:CONTEXT.—:With increasing use and efficacy of antiretroviral therapy for human immunodeficiency virus (HIV) infection, deaths from acquired immunodeficiency syndrome (AIDS)-defining conditions have decreased. OBJECTIVE.—:To examine trends in the cause of death of HIV-infected patients who underwent autopsy at a major ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2019-0144-OA

    authors: Nizami S,Morales C,Hu K,Holzman R,Rapkiewicz A

    更新日期:2020-05-01 00:00:00

  • The "P's and Q's" of quality systems.

    abstract::Quality improvement in blood collection centers has been a priority of regulatory and accrediting agencies for the past several years. The Food and Drug Administration and the American Association of Blood Banks have developed guidelines for quality assurance activities. Inspection programs have focused on evaluation ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(1999)123<0576:TPSAQS>2.0.CO;2

    authors: Hanson M

    更新日期:1999-07-01 00:00:00

  • Laboratory determination of hereditary susceptibility to breast and ovarian cancer.

    abstract::Inherited mutations in the genes BRCA1 and BRCA2 are associated with a significantly increased risk of breast cancer, particularly before the age of 50 years, as well as an increased risk of ovarian cancer. Patients with early-onset breast cancer or ovarian cancer at any age with a family history of either disease are...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/0003-9985(1999)123<1023:LDOHST>2.0.CO;2

    authors: Frank TS

    更新日期:1999-11-01 00:00:00

  • Detection of adenocarcinoma in situ of the cervix in Papanicolaou tests: comparison of diagnostic accuracy with other high-grade lesions.

    abstract:CONTEXT:Adenocarcinoma in situ of the cervix is a recently recognized interpretation in the Bethesda 2001 system. Although specific morphologic criteria have been published, recognizing this entity is still difficult. OBJECTIVE:To compare pathologists' ability to correctly identify and categorize adenocarcinoma in sit...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2004)128<153:DOAISO>2.0.CO;2

    authors: Renshaw AA,Mody DR,Lozano RL,Volk EE,Walsh MK,Davey DD,Birdsong GG

    更新日期:2004-02-01 00:00:00

  • Screening for human immunodeficiency virus antibody in urine.

    abstract:OBJECTIVE:To determine the diagnostic accuracy of an investigational test for human immunodeficiency virus (HIV) envelope antibodies in urine. DESIGN:Matched blood and urine specimens were tested for HIV by two independent laboratories, both of which were blinded to all results at the other site. Duplicate positive en...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Berrios DC,Avins AL,Haynes-Sanstad K,Eversley R,Woods WJ

    更新日期:1995-02-01 00:00:00

  • Placental mesenchymal dysplasia.

    abstract::Placental mesenchymal dysplasia is a rare placental lesion characterized by stem villous cystic dilation and vesicle formation, placentomegaly, and vascular abnormalities. It can be associated with growth restriction, stillbirth, Beckwith-Wiedemann syndrome, and some chromosomal abnormalities, and needs to be distingu...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2013-0399-RS

    authors: Pawoo N,Heller DS

    更新日期:2014-09-01 00:00:00

  • Real-time Visualization of Breast Carcinoma in Pathology Specimens From Patients Receiving Fluorescent Tumor-Marking Agent Tozuleristide.

    abstract:CONTEXT.—:Resection of breast carcinoma with adequate margins reduces the risk of local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection and margin assessment. In this study, fluorescence imaging was conducted ex vivo on g...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2018-0197-OA

    authors: Dintzis SM,Hansen S,Harrington KM,Tan LC,Miller DM,Ishak L,Parrish-Novak J,Kittle D,Perry J,Gombotz C,Fortney T,Porenta S,Hales L,Calhoun KE,Anderson BO,Javid SH,Byrd DR

    更新日期:2019-09-01 00:00:00

  • Improved technique for cutting brain slices.

    abstract::When two disposable serological pipettes with an external diameter of 1 cm are placed on the cutting surface on either side of the brain and the knife rides across them, it will cut even slices precisely 1 cm thick. Both coronal and horizontal slices can be cut as well as oblique slices for comparison with computerize...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Kaufmann JC

    更新日期:1979-01-01 00:00:00

  • Necrobiosis lipoidica in a diabetic intravenous drug user.

    abstract::Necrobiosis lipoidica occurs most commonly on the lower extremities in patients with diabetes; lesions typically occur in the pretibial region. Although the pathogenesis of necrobiosis lipoidica remains unclear, both external trauma and vascular damage have been proposed as contributing to the development of this diso...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Jordan CD,Flotte TJ,Wright SW,MacKool B,Duncan LM

    更新日期:1997-10-01 00:00:00

  • Primary embryonal carcinoma and choriocarcinoma of the mediastinum. A case report.

    abstract::Primary germinal tumors of the mediastinum are very rare. We studied a 67-year-old man with a primary embryonal carcinoma and choriocarcinoma of the mediastinum. To our knowledge, this is the oldest patient described as having this lesion. The diagnosis of primary germinal tumor of the mediastinum should not be made u...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Knapp RH,Fritz SR,Reiman HM

    更新日期:1982-10-01 00:00:00

  • Pulmonary and cardiovascular complications of obesity: an autopsy study of 76 obese subjects.

    abstract:CONTEXT:Obesity is associated with sleep disordered breathing and cardiovascular morbidity, but the relationship between pulmonary hypertension, heart disease, and obesity is unknown. OBJECTIVE:To determine the prevalence of pulmonary and cardiovascular disease in obese subjects undergoing autopsy at a large medical c...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2008)132[1397:PACCOO]2.0.CO;2

    authors: Haque AK,Gadre S,Taylor J,Haque SA,Freeman D,Duarte A

    更新日期:2008-09-01 00:00:00

  • Benign hepatocellular tumors in the young. A clinicopathologic spectrum.

    abstract::Hepatic tumors unassociated with cirrhosis were encountered in seven patients aged 10 to 19 years. Four patients had received androgens for aplastic anemia. Two patients had transfusional hemosiderosis. One patient had had a renal transplant 2 1/2 years ago. Two patients are alive at 2 3/4 and 2 1/2 years after surgic...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Chandra RS,Kapur SP,Kelleher J Jr,Luban N,Patterson K

    更新日期:1984-02-01 00:00:00

  • Reproducibility of Malignant Pleural Mesothelioma Histopathologic Subtyping.

    abstract:CONTEXT:- Malignant pleural mesothelioma (MPM) is a rare tumor with poor prognosis. Several studies have analyzed potential prognostic markers, but histologic type remains the single most important prognostic factor. Histologic subtypes of epithelioid MPM seem to have prognostic and therapeutic implications. Interobser...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2017-0295-OA

    authors: Brcic L,Vlacic G,Quehenberger F,Kern I

    更新日期:2018-06-01 00:00:00

  • Necrotizing retinopathy with herpes zoster ophthalmicus: a light and electron microscopical study.

    abstract::A necrotizing retinopathy following a vesicular cutaneous eruption in the distribution of the right trigeminal nerve developed in a patient who had been receiving systemic corticosteroid therapy one week prior to the onset of herpes zoster ophthalmicus. Seven weeks after the herpetic symptoms began, the patient died o...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Schwartz JN,Cashwell F,Hawkins HK,Klintworth GK

    更新日期:1976-07-01 00:00:00

  • Evans blue dye: its accumulation in extracellular space in relation to endothelial cell basement membrane in normal an atherosclerotic areas of abdominal aorta.

    abstract::Intravenously (IV) injected Evans blue dye consistently accumulates at particular areas in aortas of normal swine. Theses areas are also where IV injected tracer cholesterol accumulates. We studied the ultrastructural characteristics of blue vs nonblue areas in the abdominal aortas of both control and atherosclerotic ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Imai H,Scott RF,Thomas WA

    更新日期:1982-04-01 00:00:00

  • HMB-45-positive malignant lymphoma. A case report with literature review of aberrant HMB-45 reactivity.

    abstract::The monoclonal antibody HMB-45 is a highly specific and sensitive marker of malignant melanoma. Rarely, however, aberrant reactivity to nonmelanocytic tumors has been observed. We report an immunoblastic lymphoma of B-cell phenotype that reacted with HMB-45 in a 70-year-old white woman. To our knowledge, this is the f...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Friedman HD,Tatum AH

    更新日期:1991-08-01 00:00:00

  • Soft-tissue sarcoma of undetermined histogenesis: an ultrastructural study.

    abstract::A certain proportion of soft-tissue sarcomas are difficult to classify accurately. In this case report, initial light microscope observations of a soft-tissue tumor suggested a diagnosis of a monophasic synovial sarcoma. However, critical evaluation of the histologic features, results of studies with special stains, a...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Dardick I,Ho SP,McCaughey WT

    更新日期:1981-04-01 00:00:00