Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation.

abstract：:Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse func...

journal_title：Developmental biology

authors： Raftopoulou M,Hall A

更新日期：2004-01-01 00:00:00

abstract：:Wnt-11/Xfz7 signaling plays a major role in the regulation of convergent extension movements affecting the dorsal marginal zone (DMZ) of gastrulating Xenopus embryos. In order to provide data concerning the molecular targets of Wnt-11/Xfz7 signals, we have analyzed the regulation of the Rho GTPase Cdc42 by Wnt-11. In ...

journal_title：Developmental biology

authors： Penzo-Mendèz A,Umbhauer M,Djiane A,Boucaut JC,Riou JF

更新日期：2003-05-15 00:00:00

abstract：:This study was undertaken to determine whether premigratory neural crest cells of the axolotl embryo differentiate autonomously into chromatophores, or whether stimuli from the environment, particularly from the extracellular matrix, are required for this process. Neural crest cells were excised from the dorsal part o...

journal_title：Developmental biology

authors： Perris R,Löfberg J

更新日期：1986-02-01 00:00:00

abstract：:Much progress has been made in elucidating the molecular networks required for specifying retinal cells, including photoreceptors, but the downstream mechanisms that maintain identity and regulate differentiation remain poorly understood. Here, we report that the transcription factor Glass has a dual role in establish...

journal_title：Developmental biology

authors： Liang X,Mahato S,Hemmerich C,Zelhof AC

更新日期：2016-06-01 00:00:00

abstract：:Mutations that inactivate either merlin (mer) or expanded (ex) result in increased cell growth and proliferation in Drosophila. Both Mer and Ex are members of the Band 4.1 protein superfamily, and, based on analyses of mer ex double mutants, they are proposed to function together in at least a partially redundant mann...

journal_title：Developmental biology

authors： Pellock BJ,Buff E,White K,Hariharan IK

更新日期：2007-04-01 00:00:00

abstract：:Monoclonal antibodies against the surface of embryonic osteogenic cells (SB-1, SB-2, SB-3, and SB-5) have been used to characterize the sequence of transitions involved in the osteogenic cell lineage. In the present study, immunohistochemical analyses of the expression of osteogenic cell surface antigens in organ cult...

journal_title：Developmental biology

authors： Bruder SP,Caplan AI

更新日期：1990-10-01 00:00:00

abstract：:Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to in...

journal_title：Developmental biology

authors： Jones TA,Nikolova LS,Schjelderup A,Metzstein MM

更新日期：2014-06-01 00:00:00

abstract：:Type II collagen is a major component of hyaline cartilage, and has been suggested to be causally involved in promoting chondrogenesis during embryonic development. In the present study we have performed an immunohistochemical analysis of the distribution of type II collagen during several early stages of embryonic ch...

journal_title：Developmental biology

authors： Kosher RA,Solursh M

更新日期：1989-02-01 00:00:00

abstract：:Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...

journal_title：Developmental biology

authors： Bejarano F,Milán M

更新日期：2009-03-15 00:00:00

abstract：:Plant growth and development are driven by extended phases of irreversible cell expansion generating cells that increase in volume from 10- to 100-fold. Some specialized cell types define cortical sites that reinitiate polarized growth and generate branched cell morphology. This structural specialization of individual...

journal_title：Developmental biology

authors： Li J,Kim T,Szymanski DB

更新日期：2019-07-01 00:00:00

abstract：:In previous studies we found that two glycoproteins of 220 and 180 kDa account for 80-90% of the material dissolved from the vitelline coat (VC) of Unio elongatulus egg (Focarelli and Rosati, 1993). The two glycoproteins were purified by electroelution and used to raise the corresponding polyclonal antibodies. Immunof...

journal_title：Developmental biology

authors： Focarelli R,Rosati F

更新日期：1995-10-01 00:00:00

abstract：:During its development the epidermis of the pf/pf mutant mouse is invaded by cells from the underlying dermis. These invading cells establish a network of cells including fibroblasts, endothelial cells, and nerve fibers, throughout the epidermis. Subsequent to these events the keratohyalin protein, filaggrin, is drast...

journal_title：Developmental biology

authors： Fisher C,Dale BA,Kollar EJ

更新日期：1984-04-01 00:00:00

abstract：:Successful fertilization requires that sperm are activated prior to contacting an oocyte. In C. elegans, this activation process, called spermiogenesis, transforms round immobile spermatids into motile, fertilization-competent spermatozoa. We describe the phenotypic and genetic characterization of spe-43, a new compon...

journal_title：Developmental biology

authors： Krauchunas AR,Mendez E,Ni JZ,Druzhinina M,Mulia A,Parry J,Gu SG,Stanfield GM,Singson A

更新日期：2018-04-15 00:00:00

abstract：:Canonical Wnt signalling is known to be involved in the regulation of differentiation and proliferation in the context of endodermal organogenesis. Wnt mediated beta-catenin activation is understood to be modulated by secreted Frizzled-related proteins, such as XsFRP5, which is dynamically expressed in the prospective...

journal_title：Developmental biology

authors： Damianitsch K,Melchert J,Pieler T

更新日期：2009-05-15 00:00:00

abstract：:Neural crest cells migrate extensively through a complex extracellular matrix (ECM) to sites of terminal differentiation. To determine what role the various components of the ECM may play in crest morphogenesis, quail (Coturnix coturnix japonica) neural crest cells have been cultured in three-dimensional hydrated coll...

journal_title：Developmental biology

authors： Tucker RP,Erickson CA

更新日期：1984-08-01 00:00:00

abstract：:The role of angiotensin II (Ang II) in the early embryonic development of the heart has not been examined. We have used RT-PCR to identify mRNA for angiotensinogen, angiotensin-converting enzyme, and the Ang II AT1 and AT2 receptors in embryonic day 10.25 Sprague-Dawley rats, and have used confocal microscopy to local...

journal_title：Developmental biology

authors： Price RL,Carver W,Simpson DG,Fu L,Zhao J,Borg TK,Terracio L

更新日期：1997-12-15 00:00:00

abstract：:During development of the vertebrate visual system, retinal ganglion cell (RGC) axons follow a precise path toward their midbrain targets. Although much is known about the cues that direct RGC axons once they have left the optic disc, less is known about the guidance of axons at earlier stages, when RGCs first send ou...

journal_title：Developmental biology

authors： Ohta K,Tannahill D,Yoshida K,Johnson AR,Cook GM,Keynes RJ

更新日期：1999-07-01 00:00:00

abstract：:Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...

journal_title：Developmental biology

authors： Czechanski A,Kim H,Byers C,Greenstein I,Stumpff J,Reinholdt LG

更新日期：2015-06-15 00:00:00

abstract：:Heart valve structures derived from mesenchymal cells of the endocardial cushions (ECs) are composed of highly organized cell lineages and extracellular matrix. Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in the developing valves of the heart. Th...

journal_title：Developmental biology

authors： Lincoln J,Kist R,Scherer G,Yutzey KE

更新日期：2007-05-01 00:00:00

abstract：:In the marine bivalve Hiatella flaccida, full-grown oocytes in ovaries are arrested at the first prophase (prophase-I) of meiosis, whereas spawned oocytes have reinitiated meiosis from prophase-I and are again arrested at the first metaphase (metaphase-I). The neurohormone serotonin (5-hydroxytryptamine, 5-HT) was abl...

journal_title：Developmental biology

authors： Deguchi R,Osanai K

更新日期：1995-10-01 00:00:00

abstract：:Unequal first cleavage is characteristic of a diverse group of protostome animals. In the nematode Caenorhabditis elegans, unequal first cleavage is achieved through the interaction of an apparently symmetric mitotic spindle apparatus with a clearly polarized cell cortex. In the clitellate annelid Tubifex tubifex, by ...

journal_title：Developmental biology

authors： Ren X,Weisblat DA

更新日期：2006-04-01 00:00:00

abstract：:A genetically complex mutant, two-faced (tfd), which causes the production of extra eye and antennal tissue on the dorsal head cuticle, has been analyzed for connectivity to and projection patterns in the central brain of nerves derived from these extra structures. It has been found that the extra antennal nerves freq...

journal_title：Developmental biology

authors： Lipshitz HD,Kankel DR

更新日期：1985-01-01 00:00:00

abstract：:Cells that overexpress PKA as a consequence of carrying multiple copies of the gene encoding the catalytic subunit can be induced to sporulate when developing as single cells. A peptide phosphorylated by PKA, termed SDF-1, has recently been shown to stimulate this process (Anjard et al., 1997). Several genes have been...

journal_title：Developmental biology

authors： Anjard C,Zeng C,Loomis WF,Nellen W

更新日期：1998-01-15 00:00:00

abstract：:During the last stages of fetal life, the immature epithelial cells of the rat lung alveolus develop the properties of mature type 2 cells. Adult type 2 cells rapidly lose these same properties when isolated and maintained in cell culture. We have examined the synthesis of cytokeratin proteins by adult type 2 cells as...

journal_title：Developmental biology

authors： Paine R,Ben-Ze'ev A,Farmer SR,Brody JS

更新日期：1988-10-01 00:00:00

abstract：:The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. ...

journal_title：Developmental biology

authors： Rayle RE

更新日期：1991-07-01 00:00:00

abstract：:Primitive blood constitutes the ventralmost mesoderm in amphibians, and its cleavage-stage origin reveals important clues about the orientation of the dorsal/ventral axis in the embryo. In recent years, investigators employing various lineage-labeling strategies have reported disparate results for the origin of primit...

journal_title：Developmental biology

authors： Lane MC,Sheets MD

更新日期：2002-08-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) regulate a number of major developmental processes, but their roles in synovial joint formation remain unknown. Here we created conditional mouse embryo mutants lacking Ext1 in developing joints by mating Ext1(f/f) and Gdf5-Cre mice. Ext1 encodes a subunit of the Ext1/Ext2 Golgi-a...

journal_title：Developmental biology

authors： Mundy C,Yasuda T,Kinumatsu T,Yamaguchi Y,Iwamoto M,Enomoto-Iwamoto M,Koyama E,Pacifici M

更新日期：2011-03-01 00:00:00

abstract：:To form a gonad, germ cells (GCs) and somatic gonadal precursor cells (SGPs) must migrate to the correct location in the developing embryo and establish the cell-cell interactions necessary to create proper gonad architecture. During gonad morphogenesis, SGPs send out cellular extensions to ensheath the individual GCs...

journal_title：Developmental biology

authors： Jemc JC,Milutinovich AB,Weyers JJ,Takeda Y,Van Doren M

更新日期：2012-07-15 00:00:00

abstract：:Two main processes are involved in driving ventral mesendoderm internalization in the Xenopus gastrula. First, vegetal rotation, an active movement of the vegetal cell mass, initiates gastrulation by rolling the peripheral blastocoel floor against the blastocoel roof. In this way, the leading edge of the internalized ...

journal_title：Developmental biology

authors： Ibrahim H,Winklbauer R

更新日期：2001-12-01 00:00:00

abstract：:The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been...

journal_title：Developmental biology

authors： Bonini NM,Leiserson WM,Benzer S

更新日期：1998-04-01 00:00:00