Development of a chitosan-based nanoparticle formulation for delivery of a hydrophilic hexapeptide, dalargin.

abstract：:Oxaliplatin (OXA) was coupled to PEGylated polyamidoamine dendrimers of fourth generation (G4-PEG@OXA) in the comparison to PEGylated ones of odd generation (G3.5-PEG@OXA). Proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy were used to confirm the successful incorporation of OXA as well as ...

journal_title：Biopolymers

authors： Ho MN,Bach LG,Nguyen DH,Nguyen CH,Nguyen CK,Tran NQ,Nguyen NV,Hoang Thi TT

更新日期：2019-07-01 00:00:00

abstract：:In this article, the pulsed double electron-electron resonance in electron spin-echo (PELDOR) technique is applied to study the self-aggregation of spin-labeled zervamicin IIA, a hexadecapeptide antibiotic of fungal origin, which is known to form ion channels in a phospholipid double layer. Measurements of the ion cha...

journal_title：Biopolymers

authors： Milov AD,Tsvetkov YD,Gorbunova EY,Mustaeva LG,Ovchinnikova TV,Raap J

更新日期：2002-09-01 00:00:00

abstract：:Three new polyoxaalkyl esters of lasalocid are synthesized. Their ability to form complexes with Li(+) and Na(+) cations is studied using multinuclear NMR methods, FTIR spectroscopy in the middle and far IR regions, and mass spectrometry. It is found that lasalocid esters form only 1:1 complexes with the metal cations...

journal_title：Biopolymers

authors： Pankiewicz R,Schroeder G,Gierczyk B,Brzezinski B,Bartl F

更新日期：2002-10-15 00:00:00

abstract：:GSK3β plays an important role in many physiological functions; dysregulated GSK3β is involved in human diseases such as diabetes, cancer, and Alzheimer's disease. This study uses MD simulations to determine the interaction between GSK3β and a peptide derived from GSKIP, a novel GSK3β interacting protein. Results show ...

journal_title：Biopolymers

authors： Tang XN,Lo CW,Chuang YC,Chen CT,Sun YC,Hong YR,Yang CN

更新日期：2011-07-01 00:00:00

abstract：:Peptomers are oligomeric molecules composed of both α-amino acids and N-substituted glycine monomers, thus creating a hybrid of peptide and peptoid units. Peptomers have been used in several applications such as antimicrobials, protease inhibitors, and antibody mimics. Despite the considerable promise of peptomers as ...

journal_title：Biopolymers

authors： Butterfoss GL,Drew K,Renfrew PD,Kirshenbaum K,Bonneau R

更新日期：2014-09-01 00:00:00

abstract：:Elucidation of mechanisms underlying collagen fibril assembly and matrix-induced guidance of cell fate will contribute to the design and expanded use of this biopolymer for research and clinical applications. Here, we define how Type I collagen oligomers affect in-vitro polymerization kinetics as well as fibril micros...

journal_title：Biopolymers

authors： Bailey JL,Critser PJ,Whittington C,Kuske JL,Yoder MC,Voytik-Harbin SL

更新日期：2011-02-01 00:00:00

abstract：:The folding of membrane proteins was addressed using outer membrane protein porin from the soil bacterium Paracoccus denitrificans (P. den.). IR spectroscopy and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis were used to probe the effect of mutagenesis on the thermal stability of the pr...

journal_title：Biopolymers

authors： Sukumaran S,Zscherp C,Mäntele W

更新日期：2004-05-01 00:00:00

abstract：:The conformation and intermolecular association of [D-Hyi2, L-Hyi4] meso-valinomycin [cyclo[-D-Val-D-Hyi-L-Val-L-Hyi-(D-Val-L-Hyi-L-Val-D-+ ++Hyi)2-], C60H102N6O18] in a crystal form obtained from ethanol solution has been determined by x-ray crystallography. Two depsipeptides and one ethanol molecule per asymmetric u...

journal_title：Biopolymers

authors： Pletnev VZ,Ivanov VT,Langs DA,Burkhart BM,Duax WL

更新日期：1997-11-01 00:00:00

abstract：:The design of modified nucleic acid aptamers is improved by considering thermodynamics and kinetics of their association/dissociation processes. Locked Nucleic Acids (LNA) is a promising class of nucleic acid analogs. In this work the thermodynamic and kinetic properties of a LNA quadruplex formed by the TGGGT sequenc...

journal_title：Biopolymers

authors： Petraccone L,Erra E,Randazzo A,Giancola C

更新日期：2006-12-15 00:00:00

abstract：:Late expression factor 4 (LEF4) is one of the four subunits of Autographa californica nuclear polyhedrosis virus (AcNPV) RNA polymerase. LEF4 was overexpressed in Escherichia coli and recombinant protein was subjected to structural characterization. Chemical induced unfolding of LEF4 was investigated using intrinsic f...

journal_title：Biopolymers

authors： Rasheedi S,Suragani M,Haq SK,Ghosh S,Ehtesham NZ,Hasnain SE

更新日期：2009-07-01 00:00:00

abstract：:Structural data produced by a 2-ns molecular dynamics (MD) simulation on Geobacillus alanine racemase (AlaR; PDB: 1SFT) was used to study hydration around the two AlaR active sites. AlaR is a crucial enzyme for bacterial cell wall biosynthesis. It has been shown previously that the potency of an inhibitor can be incre...

journal_title：Biopolymers

authors： Huang HC,Jupiter D,Qiu M,Briggs JM,Vanburen V

更新日期：2008-03-01 00:00:00

abstract：:The thermodynamics of the stacking to unstacking transitions of 24 single-stranded DNA sequences (ssDNA), 10-12 bases in length, in sodium phosphate buffer were determined from 10 to 95 degrees C, using differential scanning calorimetry (DSC). An additional 22 ssDNA sequences did not exhibit an S<=>U transition in thi...

journal_title：Biopolymers

authors： Ramprakash J,Lang B,Schwarz FP

更新日期：2008-11-01 00:00:00

abstract：:Increasing attention is being paid to the role of selenium, both as an essential component required for the activity of many enzymes and in the context of selenium-based pharmaceutical agents. A wide range of therapeutics that include selenium are on the market and under development, such as antihypertensive, anticanc...

journal_title：Biopolymers

authors： Hartman I,Raia CA,Zauhar RJ

更新日期：2006-12-15 00:00:00

abstract：:A series of novel nonpeptide inhibitors of the pp60(c-Src) (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x-ray structure of citrate complexed to the pTyr binding site of the Src SH2 domain, these nonpeptide ligands i...

journal_title：Biopolymers

authors： Sundaramoorthi R,Kawahata N,Yang MG,Shakespeare WC,Metcalf CA 3rd,Wang Y,Merry T,Eyermann CJ,Bohacek RS,Narula S,Dalgarno DC,Sawyer TK

更新日期：2003-01-01 00:00:00

abstract：:The formation of the KRas4B-PDEδ complex activates different signaling pathways required for the development and maintenance of cancer. Previous experimental and theoretical studies have allowed researchers to design an inhibitor of the KRas4B-PDEδ complex, "Deltarasin." This inhibitor binds to the prenyl-binding pock...

journal_title：Biopolymers

authors： Bello M,Correa-Basurto J,Vargas-Mejía MÁ

更新日期：2019-11-01 00:00:00

abstract：:Side-chain lactam bridges linking amino acid residues that are spaced several residues apart in the linear sequence offer a convenient and flexible method for introducing conformational constraints into a peptide structure. The availability of a variety of selectively cleavable protecting groups for amines and carboxy...

journal_title：Biopolymers

authors： Taylor JW

更新日期：2002-01-01 00:00:00

abstract：:A comparison of amino acid sequences of yeast Rer2p and Srt1p Z-prenyltransferases shows that the spatial organization of their substrate tunnels agrees with that determined by X-ray for the E. coli undecaprenyl diphosphate synthase (UPPs). The observed trend in the maxima of product length distribution shifted from C...

journal_title：Biopolymers

authors： Poznański J,Szkopinska A

更新日期：2007-06-05 00:00:00

abstract：:Optical melting curves of 22 DNA dumbbells with the 16-base pair duplex sequence 5'-G-C-A-T-C-A-T-C-G-A-T-G-A-T-G-C-3' linked on both ends by single-strand loops of A, or C, sequences (iota = 2, 3, 4, 6, 8, 10, 14). T sequences (iota = 2, 3, 4, 6, 8, 10), and G iota sequences (iota = 2, 4) were measured in phosphate b...

journal_title：Biopolymers

authors： Paner TM,Riccelli PV,Owczarzy R,Benight AS

更新日期：1996-12-01 00:00:00

abstract：:Individual-site isotherms for the binding of bacteriophage lambda repressor to the left and right lambda operators have been determined [D. F. Senear, M. Brenowitz, M. A. Shea, and G. K. Ackers (1986) Biochemistry, Vol. 25, pp. 7344-7354.] using the DNAse protection technique [footprinting; D. J. Galas and A. Schmitz ...

journal_title：Biopolymers

authors： Saroff HA

更新日期：1993-09-01 00:00:00

abstract：:A secondary structure sequence is a symbolic string composed of three kinds of letters, indicating the helix, strand, and coil (including turns), respectively. A graphic representation for this abstract symbolic sequence is proposed here, called the S curve. The S curve is the unique representation for a given seconda...

journal_title：Biopolymers

authors： Zhang CT,Zhang R

更新日期：2000-06-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide-27 (PACAP27) are members of the secretin-glucagon family containing 28 and 27 residues, respectively. NMR spectroscopy studies suggest that the N-terminus exhibit consecutive beta-turns whereas the central and C-terminal parts o...

journal_title：Biopolymers

authors： Corcho FJ,Mokoena P,Bisetty K,Perez JJ

更新日期：2009-05-01 00:00:00

abstract：:Solid state nmr methods were applied to the study of the motions and structural heterogeneity in polyglycine, sodium poly(L-glutamate), and poly(L-alanine). The response of both the main-chain and side-chain resonances to the addition of water was studied using static and magic-angle sample-spinning line shapes as wel...

journal_title：Biopolymers

authors： Kennedy SD,Bryant RG

更新日期：1990-01-01 00:00:00

abstract：:The visual pigment rhodopsin has been extensively studied for the kinetics of its photointermediates by various spectroscopic methods. Unlike such archaeal retinal proteins as bacteriorhodopsin, visual rhodopsin does not thermally recover its dark state after photoexcitation, which precludes repeated excitation of a s...

journal_title：Biopolymers

authors： Lüdeke S,Lórenz Fonfría VA,Siebert F,Vogel R

更新日期：2006-10-05 00:00:00

abstract：:The occurrence of a highly conserved 11-mer repeating motif in the primary sequence is a major characteristic of group 3 late embryogenesis abundant (LEA3) proteins, which are strongly associated with abiotic stress tolerance of the plants. In this study, the three-dimensional structure, mimetic membrane association, ...

journal_title：Biopolymers

authors： Xue R,Liu Y,Zheng Y,Wu Y,Li X,Pei F,Ni J

更新日期：2012-01-01 00:00:00

abstract：:H-Pro-Pro-Asp-NH2 is a highly active and selective catalyst for asymmetric aldol reactions. Here, the versatility of H-Pro-Pro-Asp-NH2 has been further improved by immobilization on a solid support and functionalization with a short polyethylene glycol linker at the C-terminus. The development, synthesis, and the cata...

journal_title：Biopolymers

authors： Revell JD,Gantenbein D,Krattiger P,Wennemers H

更新日期：2006-01-01 00:00:00

abstract：:A natural rubber was identified and characterized for the first time in the latex of the perennial Mediterranean shrub Euphorbia characias. Four different methods, i.e., acetone, acetic acid, trichloroacetic acid, and Triton® X-100, followed by successive treatments with cyclohexane/ethanol, were employed to extract t...

journal_title：Biopolymers

authors： Spanò D,Pintus F,Mascia C,Scorciapino MA,Casu M,Floris G,Medda R

更新日期：2012-08-01 00:00:00

abstract：:For mimicking macromolecular crowding of DNA quadruplexes, various crowding agents have been used, typically PEG, with quadruplexes of micromolar strand concentrations. Thermal and thermodynamic stabilities of these quadruplexes increased with the concentration of the agents, the rise depended on the crowder used. A d...

journal_title：Biopolymers

authors： Kejnovská I,Vorlíčková M,Brázdová M,Sagi J

更新日期：2014-04-01 00:00:00

abstract：:The rheological characteristics of gastric and duodenal mucin solutions, the building blocks of the mucus layer that covers the epithelia of the two organs, were investigated using particle tracking microrheology. We used biochemically well characterized purified porcine mucins (MUC5AC and MUC2) as models for human mu...

journal_title：Biopolymers

authors： Georgiades P,Pudney PD,Thornton DJ,Waigh TA

更新日期：2014-04-01 00:00:00

abstract：:Combinatorial library composed of rigid rod-like peptides with a triple-helical scaffold was constructed. The component peptides were designed to have various combinations of basic and neutral (or hydrophobic) amino acid residues based on collagen-like (Gly-Pro-Yaa)-repeating sequences, inspired from the basic and amp...

journal_title：Biopolymers

authors： Masuda R,Kudo M,Dazai Y,Mima T,Koide T

更新日期：2016-11-04 00:00:00

abstract：:Despite detailed knowledge of the overall structural changes and stoichiometries of surfactant binding, little is known about which protein regions constitute the preferred sites of attack for initial unfolding. Here we have exposed three proteins to limited proteolysis at anionic (SDS) and cationic (DTAC) surfactant ...

journal_title：Biopolymers

authors： Hansen JH,Petersen SV,Andersen KK,Enghild JJ,Damhus T,Otzen D

更新日期：2009-03-01 00:00:00