The X-ray structure of the monoclinic crystal form of [D-Hyi2, L-Hyi4] meso-valinomycin.

abstract：:Optical melting curves of 22 DNA dumbbells with the 16-base pair duplex sequence 5'-G-C-A-T-C-A-T-C-G-A-T-G-A-T-G-C-3' linked on both ends by single-strand loops of A, or C, sequences (iota = 2, 3, 4, 6, 8, 10, 14). T sequences (iota = 2, 3, 4, 6, 8, 10), and G iota sequences (iota = 2, 4) were measured in phosphate b...

journal_title：Biopolymers

authors： Paner TM,Riccelli PV,Owczarzy R,Benight AS

更新日期：1996-12-01 00:00:00

abstract：:TACC3 is a centrosomal adaptor protein that plays important roles during mitotic spindle assembly. It interacts with chTOG/XMAP215, which catalyzes the addition of tubulin dimers during microtubule growth. A 3D coiled-coil model for this interaction is available but the structural details are not well described. To ch...

journal_title：Biopolymers

authors： Partida-Hanon A,Treviño MA,Mompeán M,Jiménez MÁ,Bruix M

更新日期：2017-11-01 00:00:00

abstract：:Several new biocompatible and degradable materials were prepared by chemical modification of sodium hyaluronate. The method of activation of hyaluronate by cyanogen bromide was used and subsequent reaction with nucleophile led to the formation of carbamate. This modification of hydroxyl groups of glycosaminoglycans pr...

journal_title：Biopolymers

authors： Mlcochová P,Bystrický S,Steiner B,Machová E,Koós M,Velebný V,Krcmár M

更新日期：2006-05-01 00:00:00

abstract：:The photophysics of Trp-containing peptides is extremely affected by the position of the indole ring with respect to substituents. In this work an unusual temperature fluorescence quenching behavior is presented. The N-tryptophan terminal peptides (N-Trp) show an increase of the static emission intensity as rising the...

journal_title：Biopolymers

authors： Brancaleon L,Crippa PR,Diemmi D

更新日期：1995-12-01 00:00:00

abstract：:In this study, we identified and chemically synthesized three cationic and amphipathic peptides (Glycinin-17, BCAS-16, and BCBS-11) from soybean proteins. These peptides had high isoelectric points, high positive net charges, and included multiple hydrophobic amino acids. Subsequently, we identified multiple functions...

journal_title：Biopolymers

authors： Taniguchi M,Saito K,Nomoto T,Namae T,Ochiai A,Saitoh E,Tanaka T

更新日期：2017-07-01 00:00:00

abstract：:The coupling of nuC-O and deltaO-D vibrations in the 1200-900 cm(-1) IR range leads to band shifting in opposite directions, which provides information on intramolecular hydrogen bonding of carbohydrates in aqueous solution. The aqueous solution IR spectra of 2-acetamide-1,6-anhydro-2-deoxy-D-glucopyranose and cis-1,2...

journal_title：Biopolymers

authors： Carmona P,Molina M,Aboitiz N,Vicent C

更新日期：2002-01-01 00:00:00

abstract：:The formation mechanism of an alanine-based peptide has been studied by all-atom molecular dynamics simulations with a recently developed all-atom point-charge force field and the Generalize Born continuum solvent model at an effective salt concentration of 0.2M. Thirty-two simulations were conducted. Each simulation ...

journal_title：Biopolymers

authors： Chowdhury S,Zhang W,Wu C,Xiong G,Duan Y

更新日期：2003-01-01 00:00:00

abstract：:Suppressors of Cytokine Signaling (SOCS) proteins are negative regulators of JAK proteins that are receptor-associated tyrosine kinases, which play key roles in the phosphorylation and subsequent activation of several transcription factors named STATs. Unlike the other SOCS proteins, SOCS1 and 3 show, in the N-termina...

journal_title：Biopolymers

authors： La Manna S,Lopez-Sanz L,Leone M,Brandi P,Scognamiglio PL,Morelli G,Novellino E,Gomez-Guerrero C,Marasco D

更新日期：2017-11-20 00:00:00

abstract：:Bacteria contain a diverse set of RNAs to provide tight regulation of gene expression in response to environmental stimuli. Bacterial small RNAs (sRNAs) work in conjunction with protein cofactors to bind complementary mRNA sequences in the cell, leading to up- or downregulation of protein synthesis. In vivo imaging of...

journal_title：Biopolymers

authors： Kitto RZ,Christiansen KE,Hammond MC

更新日期：2021-01-01 00:00:00

abstract：:We applied dynamic light scattering technique on the model system of hen egg lysozyme in salt-free aqueous ethanol solution to study the mechanism of denaturation and aggregation of protein. At low ethanol concentration [0-63% (v/v)], the fast relaxation mode was observed, which was caused by lysozyme molecules in the...

journal_title：Biopolymers

authors： Tanaka S,Oda Y,Ataka M,Onuma K,Fujiwara S,Yonezawa Y

更新日期：2001-10-15 00:00:00

abstract：:In the native structure of hen egg white lysozyme (HEL), the amino acid sequence 87-97 (HEL 87-97) forms an amphiphilic helix, with hydrophilic residues in the sequence directed toward the solvent. A synthetic version of the HEL 87-97 sequence (with the cysteine corresponding to position 94 of HEL replaced by alanine)...

journal_title：Biopolymers

authors： Vuilleumier S,Mutter M

更新日期：1993-03-01 00:00:00

abstract：:Multiconfiguration thermodynamic integration was used to determine the relative binding strength of tacrine and 6-chlorotacrine by Torpedo californica acetylcholinesterase. 6-Chlorotacrine appears to be bound stronger by 0.7+/-0.4 kcal/mol than unsubstituted tacrine when the active site triad residue His-440 is deprot...

journal_title：Biopolymers

authors： Wlodek ST,Antosiewicz J,McCammon JA,Straatsma TP,Gilson MK,Briggs JM,Humblet C,Sussman JL

更新日期：1996-01-01 00:00:00

abstract：:Gelsolin is an actin-severing protein whose action is initiated by Ca(2+) and inhibited by binding to phosphorylated inositol lipid or phosphoinositides. The regions of gelsolin responsible for phosphoinositide binding are comprised of residues 150-169 (G150-169) and 135-142 (G135-142). The corresponding peptides poss...

journal_title：Biopolymers

authors： Liepiņa I,Czaplewski C,Janmey P,Liwo A

更新日期：2003-01-01 00:00:00

abstract：:The enzymatic activities of native myosin light chain kinases are subject to modification by interaction with Ca2(+)-calmodulin (CaM). The interaction between myosin light chain kinase isolated from turkey gizzard (tgMLCK) and calmodulin isolated from bovine testes (CaMbt) and wheat germ (CaMwg) has been examined by m...

journal_title：Biopolymers

authors： Garone L,Albaugh S,Steiner RF

更新日期：1990-01-01 00:00:00

abstract：:Chiral interaction of helical peptide with chiral molecule, and concomitant induction in its helix sense have been demonstrated in optically inactive nonapeptide (1) possessing Gly at its N-terminus: H-Gly-(Delta(Z)Phe-Aib)(4)-OCH(3) (1: Delta(Z)Phe = Z-dehydrophenylalanine; Aib = alpha-aminoisobutyric acid). Spectros...

journal_title：Biopolymers

authors： Ousaka N,Inai Y,Okabe T

更新日期：2006-11-01 00:00:00

abstract：:A series of cyclic retro-inverso dipeptides--2-[(4-hydroxy)benzyl]-5-benzyl-4,6(1H,2H,3H,5H)-pyrimidinedi one (c[mPhe-gTyr]), 2-benzyl-5-[(4-hydroxy)benzyl]-4,6(1H,2H,3H,5H)-pyrimidinedione (c[mTyr-gPhe]), and 2-benzyl-5-amino-5-[(4-hydroxy)benzyl]-4,6(1H,2H,3H,5H)-pyrimidinedione (c[(alpha-amino)mTyr-gPhe])--were syn...

journal_title：Biopolymers

authors： Nunami K,Yamazaki T,Goodman M

更新日期：1991-11-01 00:00:00

abstract：:Different atomic point charge sets are obtained for the alpha R and C7,eq conformations of the alanine dipeptide by fitting the charges of each conformation to the respective ab initio electrostatic potential surfaces both individually and simultaneously, in both the united atom and the all-atom representations. Using...

journal_title：Biopolymers

authors： Resat H,Maye PV,Mezei M

更新日期：1997-01-01 00:00:00

abstract：:The enhanced nucleophilicity and redox sensitivity of the thiol group renders cysteine residues susceptible to numerous electrophilic and oxidative post-translational modifications to form disulfides, sulfenic acids, nitrosothiols, and lipid-modified species. Outside of these well-characterized modifications of cystei...

journal_title：Biopolymers

authors： Shannon DA,Weerapana E

更新日期：2014-02-01 00:00:00

abstract：:The beta-subunit of the human chorionic gonadotropin (hCG) hormone, which is believed to be related to certain types of cancer, contains three hairpin-like fragments. To investigate the role of beta-hairpin formation in the early stages of the hCGbeta folding, a 28-residue peptide with the sequence RDVRFESIRLPGSPRGVNP...

journal_title：Biopolymers

authors： Silva RA,Sherman SA,Keiderling TA

更新日期：1999-10-05 00:00:00

abstract：:Using a variety of spectroscopic techniques, a number of molecular functionalities have been studied in relation to the adsorption process of proteins to air-water interfaces. While ellipsometry and drop tensiometry are used to derive information on adsorbed amount and exerted surface pressure, external reflection cir...

journal_title：Biopolymers

authors： de Jongh HH,Kosters HA,Kudryashova E,Meinders MB,Trofimova D,Wierenga PA

更新日期：2004-05-01 00:00:00

abstract：:CD experiments are reported for several coiled-coil species in the tyrosine/disulfide (approximately 250-350-nm) region. Intact noncross-linked tropomyosin (approximately 3 degrees C) shows a negative nonsymmetric band maximal at 280 nm. This spectrum is the sum over six tyrosines/chain, and has conformational signifi...

journal_title：Biopolymers

authors： Holtzer ME,Kumar S,Holtzer A,Crimmins DL

更新日期：1989-09-01 00:00:00

abstract：:A series of novel nonpeptide inhibitors of the pp60(c-Src) (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x-ray structure of citrate complexed to the pTyr binding site of the Src SH2 domain, these nonpeptide ligands i...

journal_title：Biopolymers

authors： Sundaramoorthi R,Kawahata N,Yang MG,Shakespeare WC,Metcalf CA 3rd,Wang Y,Merry T,Eyermann CJ,Bohacek RS,Narula S,Dalgarno DC,Sawyer TK

更新日期：2003-01-01 00:00:00

abstract：:Proteases play crucial roles in various biological processes, and their activities are essential for all living organisms-from viruses to humans. Since their functions are closely associated with many pathogenic mechanisms, their inhibitors or activators are important molecular targets for developing treatments for va...

journal_title：Biopolymers

authors： Hamada Y,Kiso Y

更新日期：2016-11-04 00:00:00

abstract：:Because of its involvement in HIV entry, the chemokine receptor CXCR4 is an attractive target for antiretroviral drugs. Despite the large number of CXCR4 inhibitors studied, the 3D pharmacophore for binding to CXCR4 remains elusive, mainly as a result of conformational flexibility inherent in the identified ligands. I...

journal_title：Biopolymers

authors： Våbenø J,Nikiforovich GV,Marshall GR

更新日期：2006-01-01 00:00:00

abstract：:The design, synthesis, and evaluation of a novel series of receptors for protein surface recognition are described. The design of these agents is based around the attachment of four constrained peptide loops onto a central calix[4]arene scaffold. This arrangement mimics the role of the hypervariable loops in antibody ...

journal_title：Biopolymers

authors： Lin Q,Park HS,Hamuro Y,Lee CS,Hamilton AD

更新日期：1998-01-01 00:00:00

abstract：:We have studied by Raman and ir spectroscopy the structure of self-associated polyinosinic acid and polyguanylic acid in aqueous solution. The results are consistent with the formation of a four-stranded complex, which melts cooperatively near 60 degrees C in the case of poly(I) in the presence of K+ ions. The conform...

journal_title：Biopolymers

authors： Simard C,Savoie R

更新日期：1994-01-01 00:00:00

abstract：:The mechanisms of bridge-mediated electron transfer (ET) reactions vary from coherent deep tunneling to thermally activated hopping. This short review focuses on some developments in the study of protein ET mechanisms at the molecular and at the cellular levels. It explains experimental and theoretical work on the inf...

journal_title：Biopolymers

authors： Skourtis SS

更新日期：2013-01-01 00:00:00

abstract：:The present study characterizes the unfolding and folding processes of recombinant manganese peroxidase. This enzyme contains five disulfide bonds, two calcium ions, and one heme prosthetic group. Circular dichroism in the far UV was used to monitor global changes of the protein secondary structure, whereas UV-visible...

journal_title：Biopolymers

authors： Banci L,Bartalesi I,Ciofi-Baffoni S,Tien M

更新日期：2003-01-01 00:00:00

abstract：:Additive physical properties of DNA double strand polymers have been expanded in terms of 8 irreducible parameters. This provided consistency relations among the corresponding 10 duplex dimer contributions. To allow for oligomer analysis, end parameters were often added, and this would add extra degrees of freedom to ...

journal_title：Biopolymers

authors： Guerra JC

更新日期：2013-08-01 00:00:00

abstract：:GSK3β plays an important role in many physiological functions; dysregulated GSK3β is involved in human diseases such as diabetes, cancer, and Alzheimer's disease. This study uses MD simulations to determine the interaction between GSK3β and a peptide derived from GSKIP, a novel GSK3β interacting protein. Results show ...

journal_title：Biopolymers

authors： Tang XN,Lo CW,Chuang YC,Chen CT,Sun YC,Hong YR,Yang CN

更新日期：2011-07-01 00:00:00