Testosterone replacement therapy and motor function in men with spinal cord injury: a retrospective analysis.

Abstract:

OBJECTIVE:To evaluate motor function in men with spinal cord injury (SCI) given testosterone replacement therapy (TRT). DESIGN:American Spinal Injury Association (ASIA) rehabilitation discharge motor index scores were compared between men with SCI given TRT (testosterone cypionate, 200 mg, monthly; n = 50) and a comparison group (n = 480) in a retrospective study. Covariates included admission motor and FIM scores, level of injury (paraplegia/tetraplegia), days since injury, and age. RESULTS:ASIA discharge motor scores for ASIA impairment scale grades C and D were significantly different (P < 0.05) in men with incomplete SCI given TRT, relative to the comparison group. The covariate-adjusted mean discharge score for the TRT group was higher than for the comparison group. There were no significant differences in discharge FIM scores (P = 0.34) for men with incomplete injuries and no differences in the adjusted discharge ASIA motor scores (P = 0.92) or adjusted discharge FIM scores (P = 0.16) for men with complete injuries. CONCLUSION:The data support a relationship between TRT and strength gains in men with residual motor function after SCI. Prospective studies are necessary to validate these findings.

journal_name

Am J Phys Med Rehabil

authors

Clark MJ,Petroski GF,Mazurek MO,Hagglund KJ,Sherman AK,Lammy AB,Childers MK,Acuff ME

doi

10.1097/PHM.0b013e318168bbec

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

281-4

issue

4

eissn

0894-9115

issn

1537-7385

pii

00002060-200804000-00005

journal_volume

87

pub_type

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