Abstract:
:This article reviews the current status of exercise training and contraction-induced muscle-injury investigations in animal models of muscular dystrophy. Most exercise-training studies have compared the adaptations of normal and dystrophic muscles with exercise. Adaptation of diseased muscle to exercise occurs at many levels, starting with the extracellular matrix, but also involves cytoskeletal architecture, muscle contractility, repair mechanisms, and gene regulation. The majority of exercise-injury investigations have attempted to determine the susceptibility of dystrophin-deficient muscles to contraction-induced injury. There is some evidence in animal models that diseased muscle can adapt and respond to mechanical stress. However, exercise-injury studies show that dystrophic muscles have an increased susceptibility to high mechanical forces. Most of the studies involving exercise training have shown that muscle adaptations in dystrophic animals were qualitatively similar to the adaptations observed in control muscle. Deleterious effects of the dystrophy usually occur only in older animals with advanced muscle fiber degeneration or after high-resistive eccentric training. The main limitations in applying these conclusions to humans are the differences in phenotypic expression between humans and genetically homologous animal models and in the significant biomechanical differences between humans and these animal models.
journal_name
Am J Phys Med Rehabiljournal_title
American journal of physical medicine & rehabilitationauthors
Carter GT,Abresch RT,Fowler WM Jrdoi
10.1097/00002060-200211001-00016subject
Has Abstractpub_date
2002-11-01 00:00:00pages
S151-61issue
11 Suppleissn
0894-9115issn
1537-7385journal_volume
81pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the course of life satisfaction of persons with spinal cord injury and its determinants during inpatient rehabilitation and up to 1 yr after discharge. DESIGN:Prospective cohort study of 222 persons with spinal cord injury. Measurements at the start of active rehabilitation, after 3 mos, at disc...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e3181b71afe
更新日期:2009-11-01 00:00:00
abstract::Given their capacity to regenerate cells lost through injury or disease, stem cells offer new vistas into possible treatments for degenerative diseases and their underlying causes. As such, stem cell biology is emerging as a driving force behind many studies in regenerative medicine. This review focuses on the current...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,评审
doi:10.1097/PHM.0000000000000111
更新日期:2014-11-01 00:00:00
abstract::Data were collected prospectively over a 10-yr period from 53 subjects with facioscapulohumeral muscular dystrophy (FSHD) to provide a profile of impairment and disability. Manual muscle testing (MMT) indicated greater involvement of proximal musculature, although a subgroup demonstrated early weakness of the ankle do...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199509001-00007
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To explore the relationship between frontal plane ankle range of motion (ROM) and frontal plane control during gait, as determined by step-width variability and step-width range, among middle-aged and older persons with peripheral neuropathy (PN). DESIGN:Observational study of 39 adults (mean age +/- standar...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e318194fb3c
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:Recent technical progress in gait analysis has resulted in portable walkways with embedded pressure-sensitive sensors. Often claims are made in connection with new equipment of their straightforward clinical use. The purpose of the present study was to assess whether the functional ambulation profile (FAP), c...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.PHM.0000087490.74582.E0
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate feasibility and functional changes of simulated microgravity with 6-degree head-down-tilt (HDT) bed rest in acute ischemic stroke. DESIGN:Patients without lesions in the cingulate cortex and/or cerebellum were enrolled. They underwent HDT for 30 minutes twice per day f...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1097/PHM.0000000000000765
更新日期:2017-11-01 00:00:00
abstract::Thromboembolic obstruction of the brachiocephalic artery can have significant functional consequences because it threatens arterial circulation to the right upper limb and right cerebrum. A case is presented of a young man who sustained right basal ganglia infarct 2 mo after suffering multiple gunshot wounds to his ch...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199901000-00016
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess functional activities in different subgroups of patients with migraine. DESIGN:One-hundred forty subjects were uniformly divided into the following four groups: headache-free controls, migraine with aura, without aura, and chronic migraine. Subjects performed the tests walk across,...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000793
更新日期:2018-02-01 00:00:00
abstract::Recent studies have clarified the role of hypoxic-ischemic damage as a secondary factor in traumatic brain injury (TBI). Many trauma centers are now consistently using the Revised Trauma Score (Glasgow Coma Scale, systolic blood pressure, and respiratory rate) to assist with triage of multitrauma patients. This study ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199611000-00011
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:Habitual stretching exercise increases carotid arterial compliance, and acute stretching exercise increases arterial compliance in patients with myocardial infarction. However, it is not known whether this arterial adaptation is sustained after exercise. The aim of this study was to examine the effect of a si...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000498
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the effect of neuromuscular electrical stimulation burst duty cycle (BDC) and current type (sinusoidal alternating current [sAC] vs. rectangular alternating current [rAC]) on the electrically induced isometric torque (EIT) and discomfort. Pulsed current (PC) stimulatio...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000008
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the relationship between body mass index (BMI) and change in motor impairment and functional mobility after a gait rehabilitation intervention in chronic stroke subjects. DESIGN:Correlation and linear regression analyses of pretreatment and end-of-treatment Fugl-Meyer sc...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0b013e31826458c6
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to examine whether receipt of testosterone replacement therapy was associated with reduced 30-day rehospitalization after postacute care among older men with testosterone deficiency. DESIGN, PATIENTS, AND METHODS:We conducted a retrospective cohort study using a 5% national sample of...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001127
更新日期:2019-06-01 00:00:00
abstract::A severe injury on the job often results in a medical recovery period requiring either a temporary or long-term absence from work. Rehabilitation interventions emphasizing return to work may facilitate recovery and prevent workers from becoming unemployed. A review of the current literature suggests a direct relations...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199204000-00006
更新日期:1992-04-01 00:00:00
abstract::The physiatrist can now be instrumental in prolonging the survival of individuals with neuromuscular disease by using respiratory muscle aids. As a result, morbidity and mortality from cardiomyopathy are likely to increase for patients with generalized myopathies. One hundred consecutive patients with dystrophin-defic...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine proprioceptive performance in adults with hemiplegic cerebral palsy and the possibility that a home-based sensorimotor training program could improve proprioceptive performance. DESIGN:This study is a preintervention/postintervention assessment of 12 adults participating ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0000000000000100
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess and monitor the peak torque of the knee extensor and flexor muscles in flexion and extension and the reports of musculoskeletal complaints in members of the main Brazilian Paralympic athletics team through 1 yr. DESIGN:Fourteen healthy athletes from both sexes were assesse...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000244
更新日期:2015-10-01 00:00:00
abstract::Modified constraint-induced therapy and chemodenervation with botulinum toxin A are each efficacious in managing stroke-induced motor disorders; however, the application of these two promising modalities in combination is yet to be examined. This case study describes a 44-yr-old man who experienced a right middle cere...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200301000-00014
更新日期:2003-01-01 00:00:00
abstract::Studies were undertaken first to describe the invariant characteristics of gait initiation and second to better understand the function of each limb in the process of gait initiation. Analysis of variance indicated significant main effects for speed for time to onset of EMG activity and force plate recordings, time to...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199108000-00009
更新日期:1991-08-01 00:00:00
abstract::The shoulder's unique wide range of motion is largely restrained by the articular capsule and the external ligaments of the glenohumeral joint. Internally, the long head of the biceps tendon passes within the capsule and inserts on the superior lip of the glenoid labrum. Trauma distracting this tendon can tear the sup...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199511000-00011
更新日期:1995-11-01 00:00:00
abstract::A 28-year-old African American male with a history of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, tobacco use, and sickle cell trait was referred to a physiatrist at a multidisciplinary spine center with a one-year history of non-traumatic thoracic back pain that had significantly worsene...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001513
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To investigate the pathologic changes with a time sequence among patients with injured ligaments after complete mechanical unloading, based on a human anterior cruciate ligament (ACL) model. DESIGN:Pathologic examinations were done on remnants of completely ruptured ACLs at various times up to 14 wks after i...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31803215dc
更新日期:2007-04-01 00:00:00
abstract::The combined effects of robotic therapy and botulinum toxin type A (BTX-A) on upper-limb movement and function were studied in an 8(1/2)-yr-old child with hemiplegic cerebral palsy. Robotic therapy comprising repetitive, goal-directed reaching tasks was administered two times per week for 8 wks. Clinical measures incl...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31817fb346
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Patients with endstage hip arthritis have poor ambulatory function. The aim of this study was to determine if perioperative exercise programs are well tolerated by these elderly patients and if a customized program can achieve an earlier recovery of normal ambulatory function after total hip arthroplasty. DE...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00002060-200211000-00001
更新日期:2002-11-01 00:00:00
abstract::This review is concerned with the epidemiology of lower limb amputations, frequency and results of limbsaving procedures and the contemporary management of dysvascular amputees. National data showed no decline in the number and rates of amputations from 1981-1985, but the frequency of bypass surgery increased indicati...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-198808000-00003
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:In a large, population-based cohort of patients with spinal cord dysfunction, we assessed the relationship between self-reported physical function and hours of care received. DESIGN:Data were obtained by a cross-sectional, self-administered survey used to help establish a national registry of veterans with s...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200109000-00007
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the immediate effects of a 6-mo combined exercise program on quality-of-life, physical function, depression, and aerobic capacity in women with fibromyalgia syndrome and to determine the impact of repeated delivery of the intervention. DESIGN:Forty-one women with fibromyalgia wer...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0b013e31824faa03
更新日期:2012-07-01 00:00:00
abstract::Functional tests are commonly used to evaluate the functional ability of older individuals; however, intraday reliability and sensitivity are required to enable informed decisions on whether repeated trials are necessary and to ensure that the values obtained from a single session are a patient's true score. This stud...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0000000000000078
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To define and propose clinically useful quantitative measurements of hip hiking and circumduction using standard three-dimensional motion analysis techniques. DESIGN:We studied pelvic, hip, and thigh motions in 23 subjects with hemiparetic, stiff-legged gait as a result of stroke and compared these motions w...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200005000-00006
更新日期:2000-05-01 00:00:00
abstract::Although physicians are aware of phantom limb pain, which can occur in up to 85% of patients who undergo amputation, and its potential effect on functional status, the presence of phantom pain after amputation of other body parts such as the breast and its effect on function may be less appreciated. We report the case...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.phm.0000133430.27325.c4
更新日期:2004-08-01 00:00:00