Abstract:
:Given their capacity to regenerate cells lost through injury or disease, stem cells offer new vistas into possible treatments for degenerative diseases and their underlying causes. As such, stem cell biology is emerging as a driving force behind many studies in regenerative medicine. This review focuses on the current understanding of the applications of stem cells in treating ailments of the human brain, with an emphasis on neurodegenerative diseases. Two types of neural stem cells are discussed: endogenous neural stem cells residing within the adult brain and pluripotent stem cells capable of forming neural cells in culture. Endogenous neural stem cells give rise to neurons throughout life, but they are restricted to specialized regions in the brain. Elucidating the molecular mechanisms regulating these cells is key in determining their therapeutic potential as well as finding mechanisms to activate dormant stem cells outside these specialized microdomains. In parallel, patient-derived stem cells can be used to generate neural cells in culture, providing new tools for disease modeling, drug testing, and cell-based therapies. Turning these technologies into viable treatments will require the integration of basic science with clinical skills in rehabilitation.
journal_name
Am J Phys Med Rehabiljournal_title
American journal of physical medicine & rehabilitationauthors
Maldonado-Soto AR,Oakley DH,Wichterle H,Stein J,Doetsch FK,Henderson CEdoi
10.1097/PHM.0000000000000111subject
Has Abstractpub_date
2014-11-01 00:00:00pages
S132-44issue
11 Suppl 3eissn
0894-9115issn
1537-7385journal_volume
93pub_type
杂志文章,评审abstract:OBJECTIVE:The aim of this study was to determine the contribution of spontaneous post-stroke physical activity to skeletal muscle plasticity after stroke. DESIGN:A randomized controlled study was conducted of 24 young adult male Sprague-Dawley rats assigned to three experimental groups: (1) STR-hemorrhagic stroke in t...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31825f18e1
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of botulinum toxin A on associated pain and functional impairment of refractory plantar fasciitis. DESIGN:This is a randomized, double-blind, placebo-controlled study of 27 patients (43 feet) with plantar fasciitis. Block randomization was performed using computer software. In patie...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.phm.0000176339.73591.d7
更新日期:2005-09-01 00:00:00
abstract::This study sought to evaluate the timing of burn-associated polyneuropathy (BAPN) and its relationship to burn severity or size. Seventeen burned subjects were studied 1 wk after thermal burns. Eleven subjects remained in the study to complete 6-wk follow-up studies. Nerve conduction studies were done on at least thre...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199501000-00005
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To report patient satisfaction and quality outcomes from a standardized, multicenter fall prevention screening clinic. DESIGN:Referrals were made to the fall prevention screening clinic, which was staffed by a physician, pharmacist, therapist, nurse, and the site coordinator. The fall prevention screening cl...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.phm.0000233209.49518.46
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:1) Describe frequency of back pain only, neck pain only, and co-occurring pain in Veterans with upper limb amputation (ULA); 2) examine changes in pain over one year; and 3) quantify the association of pain and health-related quality of life (HRQoL) and disability. DESIGN:Observational cohort study with a su...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001694
更新日期:2021-01-11 00:00:00
abstract::This is the 10th annual report describing patients discharged from comprehensive medical rehabilitation programs in the United States that subscribe to the Uniform Data System for Medical Rehabilitation. The analysis included 298,973 complete records of first admission cases discharged alive from 676 facilities in 199...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200202000-00010
更新日期:2002-02-01 00:00:00
abstract::Twenty-four women employed as computer operators were evaluated for complaints of occipital headaches, as well as neck and shoulder pain. Although the symptoms were highly variable with respect to duration, intensity and distribution, they were mutually consistent in that they started or intensified with the resumptio...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-198908000-00006
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:The goal of expanding access to individuals with disabilities to scientific and medical conferences is supported by both the Americans with Disabilities Act and the National Institutes of Health. DESIGN:Live-streaming video broadcast over the internet is widely available, although it has been used only in a ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200011000-00005
更新日期:2000-11-01 00:00:00
abstract::Bilateral forearm and hand transplantation poses unique challenges especially in the setting of bilateral lower limb amputations. A 57-yr-old man with bilateral transradial amputations and bilateral transtibial amputations after remote streptococcal sepsis was admitted for inpatient rehabilitation because of severe de...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e3182240a73
更新日期:2011-08-01 00:00:00
abstract::Cognitive dysfunction among cancer survivors, commonly referred to as "chemobrain," has gained increased attention in the last decade. Cognitive dysfunction is now well recognized among patients with non-central nervous system cancers. It may be a consequence of the cancer, its treatment, or both. Other common problem...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,评审
doi:10.1097/PHM.0b013e31820be463
更新日期:2011-05-01 00:00:00
abstract::The mission statements of academic medical centers call on them to accomplish many goals. This often leads to conflicting choices when selecting activities and establishing policies. When individual faculty members are expected to divide work time to meet research, teaching and clinical needs, careful planning and dis...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199302000-00013
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the rehabilitation length of stay and functional outcome of patients with amputation on chronic dialysis with a similar group of patients not on dialysis. DESIGN:This was a retrospective cohort study. Twenty-five patients with amputations on chronic dialysis and 25 nonren...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000259
更新日期:2015-04-01 00:00:00
abstract::The steady state profiles of 63 men with traumatic spinal cord injuries (24 quadriplegics and 39 paraplegics; average age of 31.2 +/- 6.8 yr; 18-44 yr) were studied. The average length of post-traumatic period was 6.2 +/- 5.0 yr, ranging from 8 months to 20 yr. It was found that all the subjects had normal serum thyro...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199212000-00004
更新日期:1992-12-01 00:00:00
abstract::Concerns about drug-resistant infectious organisms are increasing in rehabilitation facilities. Resulting isolation protocols can potentially challenge the patients' access to medical care, psychological adaptation, mobility, and environmental interaction and therefore hinder the rehabilitation process. We report a sy...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e3181c9d847
更新日期:2010-04-01 00:00:00
abstract:ABSTRACT:Hospice and palliative medicine (HPM) is one of seven accredited fellowship subspecialties available to graduates of physical medicine and rehabilitation (PM&R) residency programs. HPM and PM&R share many of the same principles and practices, and PM&R residency training can be excellent preparation for HPM fel...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001708
更新日期:2021-01-25 00:00:00
abstract:OBJECTIVES:To establish the correlations of measures of self-reported disability, self-efficacy, physical performance, level of pain, and estimates of aerobic capacity (PvO2 ) in subjects with low back pain. DESIGN:Fifty-one low back pain subjects, ranging in age from 26 to 65 yr, entered the study. Participants compl...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200212000-00005
更新日期:2002-12-01 00:00:00
abstract::Visual deficits after cerebral injury are common. The variability in the types of injury sustained as well as their impact on function in the environment have produced multiple approaches at corrective intervention. To assess the effectiveness of these vision interventions, an extensive literature search was completed...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,评审
doi:10.1097/PHM.0b013e318151f907
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:This study examined the magnitude of work-related disability in postmenopausal women with breast cancer compared with healthy controls. It also examined demographic and clinical correlates of work-related disability in postmenopausal women with breast cancer. STUDY DESIGN:This was an exploratory secondary an...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001138
更新日期:2019-07-01 00:00:00
abstract::This report relays practical clinical information about the modification and use of commercially available training robot manipulators. Such manipulators were used to increase independence in the activities of daily living of patients with advanced Duchenne muscular dystrophy. The control panels of five industrial rob...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::The F-response is a valuable tool for evaluating the functional integrity of proximal nerve segments. Although many studies have focused on the various F-response characteristics observed (e.g., latency, amplitude, duration, persistence, etc.), few have examined the significance of stimulus parameters on the resultant...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199409000-00003
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:Decreased postural stability is a common problem associated with hemiparesis secondary to stroke. The purpose of this study was to evaluate dynamic postural control in patients with hemiparesis and in normal subjects matched for age. DESIGN:Quantitative posturography (EquiTest System) was performed to assess...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Although Transcutaneous Electrical Nerve Stimulation (TENS) has become a popular modality in pain management over the past 20 yr, there is still debate over its mechanisms of action and the precise relevance of stimulation parameters to its hypoalgesic effects. Thus, confusion still surrounds the selection of optimal ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-05-01 00:00:00
abstract::The hemipelvectomy, most commonly performed for pelvic tumor resection, is one of the most technically demanding and invasive surgical procedures performed today. Adequate soft tissue coverage and wound complications after hemipelvectomy are important considerations. Rehabilitation after hemipelvectomy is optimally ma...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,评审
doi:10.1097/PHM.0000000000000068
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:The 6-min walk test (6mWT) is widely used to assess physical performance in cardiac rehabilitation settings. Factors affecting the walked distance before starting physical training have been described, whereas information on factors affecting the increase of the walked distance after physical training is stil...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31815e67d8
更新日期:2008-01-01 00:00:00
abstract::Wegener's granulomatosis is a multisystem disease distinguished by a triad of necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis and systemic, small vessel vasculitis. The latter can cause neurologic manifestations when the vasa nervorum are affected. A 53-yr-old ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199202000-00003
更新日期:1992-02-01 00:00:00
abstract::An obstacle course, consisting of a series of 12 simulated functional tasks, has been developed to aid in the evaluation of rehabilitation interventions for elderly individuals with balance and mobility dysfunction. The validity of the obstacle course as a measure of balance and functional mobility was tested by compa...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199603000-00003
更新日期:1996-03-01 00:00:00
abstract::A 50-yr-old man arrived at our department for a rehabilitation prescription after a right knee medial collateral ligament sprain. Magnetic resonance imaging showed medial collateral ligament partial rupture and medial femoral condyle increased signal intensity indicating bone edema. After treatment, the patient still ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e3181d8d2ae
更新日期:2010-05-01 00:00:00
abstract::We describe a 38-yr-old polio survivor with newly developed weakness from myotonic dystrophy. He suffered muscle atrophy and weakness in his legs as a result of poliomyelitis at the age of 3 yrs. After a stable interval of about 30 yrs, he felt new weakness and fatigue in his legs. Electromyography revealed generalize...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e318190b935
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of selective blocking of the anterior branch of the obturator nerve by using phenol in controlling adductor spasticity in children with cerebral palsy. DESIGN:To study the anatomic location of the anterior branch of the obturator nerve with respect to bony landmarks in the inguinal are...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31815b6381
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the change in the balance performance and the improvement in the gait performance of subjects with hemiparesis, as a result of their wearing an ankle-foot orthosis. DESIGN:This was a cross-sectional control trial. Fifty-eight subjects with hemiparesis of a duration of less than 6 mos participated i...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1097/PHM.0b013e31806dd0d3
更新日期:2007-07-01 00:00:00