Lower gastrointestinal bleeding associated with diclofenac topical patch in a patient with colonic mass and on antiplatelet therapy for atrial fibrillation.

Abstract:

:Topical formulations of diclofenac, a nonsteroidal anti-inflammatory drug commonly prescribed to treat musculoskeletal complaints such as osteoarthritis, low back pain, and myofascial pain, are available in the form of a solution, gel, and patch. The topical application of diclofenac results in substantially lower systemic exposure to diclofenac compared with oral diclofenac, resulting in a more favorable side effect profile. To the authors' knowledge, this is the first case report of a lower gastrointestinal bleed associated with diclofenac topical patch use in a 77 yr-old-woman with a history of colonic mass and atrial fibrillation on antiplatelet therapy.

journal_name

Am J Phys Med Rehabil

authors

Lee J,Burke DT

doi

10.1097/PHM.0000000000000172

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1014-7

issue

11

eissn

0894-9115

issn

1537-7385

journal_volume

93

pub_type

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