Neuroendocrine changes during functional electrical stimulation.

Abstract:

:This study examined the effects of a computerized functional electrical stimulation exercise program on plasma beta-endorphin-like immunoreactivity (BEP-ir), cortisol levels and depression parameters in spinal cord-injured individuals. Nine subjects from 1.2 to 33.5 yr postinjury with both motor and sensory complete lesions between C5 and T12 participated. It was determined that patients who sustained spinal cord-injuries less than 5 yr before this study had lower than normal baseline levels of BEP-ir and flattened circadian rhythms. Patients who sustained their injury greater than 5 yr before this study had higher baseline levels of BEP-ir with some return to normal circadian rhythmicity. Baseline cortisol levels, regardless of time since injury, appeared to be dysregulated. Regular exercise with computerized functional electrical stimulation caused significantly (P less than 0.05) sustained increases in BEP-ir in all patients and improved the regulation of cortisol. Furthermore, the more strenuous the exercise training, greater increases in BEP-ir levels were seen. Last, depression scores improved, which suggests a possible association between subjective mood and BEP-ir levels.

journal_name

Am J Phys Med Rehabil

authors

Twist DJ,Culpepper-Morgan JA,Ragnarsson KT,Petrillo CR,Kreek MJ

doi

10.1097/00002060-199206000-00006

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

156-63

issue

3

eissn

0894-9115

issn

1537-7385

journal_volume

71

pub_type

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