Abstract:
:This preliminary study was designed to investigate the effects of botulinus toxin Type A and phenol treatments on electrophysiologic tests evaluating spinal afferent and efferent motor pathways involved in spasticity. The questions posed were whether different types of mechanisms act on reducing spasticity with these different treatment modalities and whether the tests are correlated with clinical recovery. Twenty patients with lower limb spasticity secondary to stroke were randomly assigned to receive 400 mouse units of botulinus toxin Type A injected into the calf muscles or to receive a tibial nerve blockade with 3 ml of 5% phenol. The amplitudes of the Achilles tendon response, M response, H reflex response, and maximum H:M ratio and Achilles tendon response to H response ratio were recorded from the soleus muscle at baseline and at Weeks 2, 4, and 12. The most obvious change was a reduction in the amplitude of the tendon response in the group that received botulinus toxin Type A, and it was a reduction in the M response amplitude in the group that received phenol. The decrease in the tendon response amplitude and tendon response to H ratio in the group that received botulinus toxin Type A and the decrease in the M response amplitude in the phenol group were found to be well correlated with clinical recovery as assessed by the Ashworth scale. The findings suggested that botulinus toxin Type A injection decreases spasticity primarily by affecting the fusimotor system and muscle spindle, and the involvement of the alpha-motor fibers within the tibial nerve is the most likely factor contributing to the reduction of spasticity after phenol blockade. The therapeutic effectiveness of these agents could be assessed and followed up by the changes in electrophysiologic responses matching their mechanisms of action. The findings should be supported by further electrophysiologic techniques.
journal_name
Am J Phys Med Rehabiljournal_title
American journal of physical medicine & rehabilitationauthors
On AY,Kirazli Y,Kismali B,Aksit Rdoi
10.1097/00002060-199907000-00010subject
Has Abstractpub_date
1999-07-01 00:00:00pages
344-9issue
4eissn
0894-9115issn
1537-7385journal_volume
78pub_type
临床试验,杂志文章,随机对照试验abstract::The physiatrist can now be instrumental in prolonging the survival of individuals with neuromuscular disease by using respiratory muscle aids. As a result, morbidity and mortality from cardiomyopathy are likely to increase for patients with generalized myopathies. One hundred consecutive patients with dystrophin-defic...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate feasibility and functional changes of simulated microgravity with 6-degree head-down-tilt (HDT) bed rest in acute ischemic stroke. DESIGN:Patients without lesions in the cingulate cortex and/or cerebellum were enrolled. They underwent HDT for 30 minutes twice per day f...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1097/PHM.0000000000000765
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To establish the correlations of measures of self-reported disability, self-efficacy, physical performance, level of pain, and estimates of aerobic capacity (PvO2 ) in subjects with low back pain. DESIGN:Fifty-one low back pain subjects, ranging in age from 26 to 65 yr, entered the study. Participants compl...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200212000-00005
更新日期:2002-12-01 00:00:00
abstract::A 35-yr-old man sustained an anoxic brain injury resulting from cardiac arrest, with subsequent extreme lethargy and lack of response to stimuli. The patient's lethargy was unresponsive to trials of several medications in attempts to increase arousal. Administration of twice-daily zolpidem 8 mos after injury resulted ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,评审
doi:10.1097/PHM.0b013e318161971b
更新日期:2008-03-01 00:00:00
abstract::Thromboembolic obstruction of the brachiocephalic artery can have significant functional consequences because it threatens arterial circulation to the right upper limb and right cerebrum. A case is presented of a young man who sustained right basal ganglia infarct 2 mo after suffering multiple gunshot wounds to his ch...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199901000-00016
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare pain induced by magnetic stimulation of the quadriceps femoris (QF) muscle with that induced by transcutaneous neuromuscular electrical stimulation (NMES). DESIGN:Magnetic stimulation and transcutaneous NMES were applied to QF muscles of 17 normal volunteers. The in...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1097/01.phm.0000223239.93539.fe
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:In a large, population-based cohort of patients with spinal cord dysfunction, we assessed the relationship between self-reported physical function and hours of care received. DESIGN:Data were obtained by a cross-sectional, self-administered survey used to help establish a national registry of veterans with s...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200109000-00007
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To determine if standardized testing results and other factors correlate with success on the 2001 American Board of Physical Medicine and Rehabilitation part 1 board certification examination (POE). DESIGN:An anonymous two-part survey was distributed to 302 senior resident physicians in the American College ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.PHM.0000083688.23340.EA
更新日期:2003-09-01 00:00:00
abstract::Fatigue is the most commonly reported and most disabling of all post-polio sequelae (PPS). Bromocriptine mesylate (Parlodel) was employed in a placebo-controlled trial in five survivors of paralytic polio who continued to report moderate to severe daily fatigue after complying with the conservative treatments prescrib...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1097/00002060-199609000-00007
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to test whether fractionated irradiation in photobiomodulation therapy enhances short-term recovery in patients with moderate severity ankle sprain. DESIGN:Nineteen patients were randomly assigned to one of two groups: one group receiving photobiomodulation therapy combined with the...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0000000000001178
更新日期:2019-08-01 00:00:00
abstract::Fall prevention requires a multifaceted approach that should include individual risk assessment and intervention strategies. Exercise interventions may mitigate most risk factors for falls (eg, balance impairment, gait impairment, and muscle weakness). Numerous systematic reviews or meta-analyses have assessed the eff...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,meta分析
doi:10.1097/PHM.0000000000001247
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Pain during needle electrode examination (NEE) is often poorly tolerated. No previous studies have evaluated the effect of lidocaine iontophoresis on pain reduction during NEE. Our objective was to determine whether pretreatment with lidocaine iontophoresis mitigates the pain felt during NEE. DESIGN:In this ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0b013e318228c6d3
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to observe the changes in endothelial and inflammatory markers in middle-aged male runners with exercise-induced hypertension (EIH) at baseline and at 100-km, 200-km, and 308-km checkpoints during a prolonged endurance ultramarathon. DESIGN:Among a total of 62 ultramarathon voluntee...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31829232db
更新日期:2013-06-01 00:00:00
abstract::Skeletal muscle function is critical to movement and one's ability to perform daily tasks, such as eating and walking. One objective of this article is to review the contractile properties of fast and slow skeletal muscle and single fibers, with particular emphasis on the cellular events that control or rate limit the...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,评审
doi:10.1097/01.PHM.0000059336.40487.9C
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine the associations of onset days, time from stroke onset to inpatient rehabilitation facility (IRF) admission, and patient outcomes (FIM gain, discharge destination, and IRF length of stay), using nationally representative data. DESIGN:A secondary data analysis was conducte...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000226
更新日期:2015-02-01 00:00:00
abstract::The Research Agenda Setting Process is a joint endeavor by the American Geriatrics Society and the Hartford Foundation to increase geriatric expertise in the surgical and related specialties. This article provides the results of the Research Agenda Setting Process project on research needs in geriatric rehabilitation,...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,评审
doi:10.1097/01.phm.0000143435.79146.9f
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:: The aim of this study was to assess the utility of quantitative ultrasound of the calcaneus in diagnosing osteoporosis in spinal cord injury patients in a Brazilian Teaching Hospital. DESIGN:: This is a diagnostic test criterion standard comparison study. Between January 2008 and October 2009, the bone den...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31821a7386
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of 25-hydroxyvitamin D insufficiency and deficiency in the outpatient rehabilitation setting and to identify patient characteristics associated with low serum 25-hydroxyvitamin D levels. DESIGN:25-Hydroxyvitamin D levels from 136 rehabilitation outpatients at an academic rehabilitati...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e3181f71112
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the effectiveness of proprioceptive exercises on shoulder proprioception, range of motion, pain, muscle strength, and function in patients with subacromial impingement syndrome. DESIGN:Sixty-one patients with subacromial impingement syndrome participated in this pr...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0000000000000327
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:In vivo measurement of articular cartilage thickness is a significant marker of structural joint damage in many inflammatory or noninflammatory diseases including rheumatoid arthritis or osteoarthritis. The aim of this study was to assess the diurnal variation of femoral condylar cartilage thickness (FCT) in ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000179
更新日期:2015-04-01 00:00:00
abstract::The translation of knowledge from exercise training research into the clinical management of multiple sclerosis, stroke, and Parkinson disease requires evidence-based guidelines that are uniformly recognizable by healthcare practitioners and patients/clients. This article synthesized resources that reported aerobic an...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001174
更新日期:2019-07-01 00:00:00
abstract::The os intermetatarseum is a rare accessory bone of the foot. It is commonly asymptomatic, as are other such accessory bones of the foot. Nevertheless, when it becomes symptomatic, it can cause "os intermetatarseum syndrome". The case is here reported of os intermetatarseum syndrome, which is extremely rarely seen. To...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001664
更新日期:2020-12-11 00:00:00
abstract::A 28-year-old African American male with a history of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, tobacco use, and sickle cell trait was referred to a physiatrist at a multidisciplinary spine center with a one-year history of non-traumatic thoracic back pain that had significantly worsene...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001513
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the effectiveness of different glove types on mobility performance in a series of field tests specific to wheelchair rugby. DESIGN:Ten international wheelchair rugby players performed three drills in each glove condition: (i) players' current glove selection, (ii) A...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e3181aa41c5
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to design patient-oriented risk models that elucidate the interactions among depressive symptoms, physical function, and sociodemographic markers and delineate the association of these indicators with 30-day readmissions. DESIGN:This prospective longitudinal study examined readmis...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000213
更新日期:2015-07-01 00:00:00
abstract::A 58-yr-old woman presented after experiencing left hip and groin pain for 1 mo. She denies any history of trauma, falls or any bruising, or history of sports injury or extreme physical exertion before her symptoms. On ultrasonography, she was found to have an avulsion tear at the origin of the adductor muscles, predo...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000000
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Seventy-nine percent of respondents to the 1990 National Post-Polio Survey reported difficulty "thinking of words I want to say," with 37% reporting frequent, moderate-to-severe word finding difficulty. This study was undertaken to objectively document polio survivors' word finding difficulty and to identify ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-200007000-00005
更新日期:2000-07-01 00:00:00
abstract::Twenty-four women employed as computer operators were evaluated for complaints of occipital headaches, as well as neck and shoulder pain. Although the symptoms were highly variable with respect to duration, intensity and distribution, they were mutually consistent in that they started or intensified with the resumptio...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-198908000-00006
更新日期:1989-08-01 00:00:00
abstract::Patients with spinal cord injury (SCI) possess higher arterial stiffness index (SI) than the healthy population. This study aimed to clarify the effect of post-morbid duration on arterial stiffening change among SCI sufferers. Seventy-one SCI patients were recruited. The demographic data including age, gender, level o...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000565
更新日期:2017-02-01 00:00:00
abstract::A combination of in vivo and in vitro analyses was performed to investigate muscular and neural adaptations of the weaker (nondominant) quadriceps femoris muscle of one healthy individual to short-term electrostimulation resistance training. The increase in maximal voluntary strength (+12%) was accompanied by neural (...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.phm.0000197570.03343.18
更新日期:2006-02-01 00:00:00