Abstract:
:Fatigue is the most commonly reported and most disabling of all post-polio sequelae (PPS). Bromocriptine mesylate (Parlodel) was employed in a placebo-controlled trial in five survivors of paralytic polio who continued to report moderate to severe daily fatigue after complying with the conservative treatments prescribed for PPS. Placebo was given for 4 wk followed by increasing doses of bromocriptine mesylate, administered at 12:00 pm for 28 days, which reached a total dose of 12.5 mg/day. Three subjects reported marked symptom improvement on bromocriptine but not on placebo. Their reported difficulty with attention, concentration, word finding, mind wandering, memory, thinking clearly, and fatigue on awakening was significantly negatively correlated with days on bromocriptine but not with days on placebo. Before the drug trial began, responders had clinically impaired performance on neuropsychologic tests of attention and information processing speed, more than twice as many hyperintensities on magnetic resonance imaging of the brain, abnormally low fasting adrenocorticotropic hormone levels, and nearly double the mean plasma prolactin level compared with nonresponders. The implications of these findings for the pathophysiology of fatigue are discussed. A double-blind, placebo-controlled, multicenter study will be needed to confirm bromocriptine's efficacy in treating attentionally and neurophysiologically impaired polio survivors whose severe and disabling fatigue does not respond to conservative therapies.
journal_name
Am J Phys Med Rehabiljournal_title
American journal of physical medicine & rehabilitationauthors
Bruno RL,Zimmerman JR,Creange SJ,Lewis T,Molzen T,Frick NMdoi
10.1097/00002060-199609000-00007subject
Has Abstractpub_date
1996-09-01 00:00:00pages
340-7issue
5eissn
0894-9115issn
1537-7385journal_volume
75pub_type
临床试验,杂志文章abstract::Fibromyalgia is a musculoskeletal disorder characterized by generalized myalgias, arthralgias widespread tender points in discreet areas on examination. It is frequently accompanied by fatigue, stiffness, and a nonrestorative sleep pattern. These patients generally have a normal blood count and chemistry profile. Ther...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199705000-00014
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the effects of ethyl chloride and placebo sprays for reducing pain induced by needle electromyography and changes in parameters of the motor unit action potential during needle electromyography of the upper extremity. DESIGN:Sixty patients were randomized into the ethyl c...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0000000000000106
更新日期:2014-10-01 00:00:00
abstract::Research training equips residents with the skills to consume and produce research evidence and deliver evidence-based care. Within Physical Medicine and Rehabilitation, studies have historically demonstrated low rates of resident research productivity. Although Canadian residency requirements mandate research partici...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001299
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:Trapezius myalgia or, more specifically, myofascial dysfunction of the upper trapezius mainly affects women performing jobs requiring prolonged low level activation of the muscle. This continuous low muscle load can be accompanied by a shift to a more anaerobic energy metabolism, causing pain. The aim of the ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001231
更新日期:2019-11-01 00:00:00
abstract::Intrathecal baclofen (ITB) therapy is widely used in the management of spastic hypertonia and dystonia resulting from a multitude of conditions that present with upper motor neuron syndrome signs, such as cerebral palsy, stroke, brain and spinal injuries, and multiple sclerosis. We report successful management of post...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.phm.0000233173.32432.6f
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To determine if standardized testing results and other factors correlate with success on the 2001 American Board of Physical Medicine and Rehabilitation part 1 board certification examination (POE). DESIGN:An anonymous two-part survey was distributed to 302 senior resident physicians in the American College ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.PHM.0000083688.23340.EA
更新日期:2003-09-01 00:00:00
abstract::We report a patient with a previously undiagnosed spinal dural arteriovenous fistula (SDAVF) who became acutely paraplegic following a lumbar epidural steroid injection for lumbar spinal stenosis. Magnetic resonance imaging showed multiple flow voids and serpentine vessels on the cord surface with cord edema extending...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000645
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the clinical ratings of elbow strength obtained by skilled clinicians with objective strength measurement obtained through quantitative testing. DESIGN:A retrospective comparison of subject clinical records with quantitative strength testing results in a motion analysis l...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31825f14f9
更新日期:2012-10-01 00:00:00
abstract::Abnormality of absolute values of median sensory conduction velocities and differences in conduction velocity between median and ulnar nerves are used as criteria for abnormality in the diagnosis of carpal tunnel syndrome. Detailed studies of sensory conduction in various median and ulnar branches and segments indicat...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-198910000-00002
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVES:To investigate testosterone and free testosterone levels in male patients after spinal cord injury (SCI) in comparison with healthy subjects, the effects of free testosterone on Functional Independence Measure (FIM) instrument, and their relationship between time since injury, spinal cord injury levels, and ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e318151fa70
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this retrospective cohort study was to compare range of motion, subjective outcomes, and the prevalence of reoperation in groups of frozen shoulder patients with either low or moderate/high irritability treated with the same total end range time-maximizing protocol. DESIGN:A total of 36 patien...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e318214ed0d
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the effect of neuromuscular electrical stimulation burst duty cycle (BDC) and current type (sinusoidal alternating current [sAC] vs. rectangular alternating current [rAC]) on the electrically induced isometric torque (EIT) and discomfort. Pulsed current (PC) stimulatio...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000008
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:Promoting an active lifestyle through an appropriate physical exercise prescription is one of the major targets of cardiac rehabilitation. However, information on the effectiveness of cardiac rehabilitation in promoting lifestyle changes in elderly patients is still scant. DESIGN:In 131 patients over the age...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e3181b332a1
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Patients hospitalized with traumatic brain injury comprise a large portion of the population treated at trauma centers, and physiatry consultants evaluate many traumatic brain injury patients in this setting. The purpose of this study was to delineate relationships between physical medicine and rehabilitation...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.PHM.0000073825.09942.8F
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To investigate whether there is a difference in functional improvement in the affected arm of chronic stroke patients when comparing two methods of electrical stimulation. DESIGN:Explanatory trial in which 30 chronic stroke patients with impaired arm function were randomly allocated to either alternating ele...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/01.phm.0000133435.61610.55
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:Equine-assisted therapies, such as therapeutic riding and hippotherapy, are believed to have positive physical and emotional effects in individuals with neuromotor, developmental, and physical disabilities. The purpose of this review was to determine whether therapeutic riding and hippotherapy improve balance...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.1097/PHM.0000000000000726
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to systematically review the efficacy and safety of exercise in patients with amyotrophic lateral sclerosis (ALS). DESIGN:Randomized controlled trials of exercises for ALS were searched in PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine database, China Natio...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,meta分析
doi:10.1097/PHM.0000000000001419
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Dopaminergic agents may stimulate behavior and verbal expression after frontal lobe dysfunction. Although amantadine is used in neurorehabilitation of motivational disorders and head injury, it is not commonly prescribed to improve aphasia. This pilot study examined verbal fluency on and off amantadine for no...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31811473b3
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:The so-called bone-derived growth factor, beta2-microglobulin, has a regulatory function in bone metabolism by stimulating osteoclast activity. We undertook this study because osteoclast activity is known to be enhanced in patients with immobilized stroke, suggesting that their beta2-microglobulin concentrati...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,收录出版
doi:10.1097/00002060-200101000-00005
更新日期:2001-01-01 00:00:00
abstract::This article was prepared by physiatry residency training directors to provide the answer(s) to common questions asked by medical students with respect to the specialty. These responses should aid the student and their advisors in considering Physical Medicine and Rehabilitation as their career choice. ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:Upper limb spasticity may impair the use of control interfaces such as joysticks for many individuals with disabilities such as cerebral palsy (CP). The aims of this study were to compare the driving performance of those with CP to that of control participants, to identify the impact of lead time on performan...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0b013e31825a1497
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To compare cough peak flows (CPF), peak expiratory flows (PEF), and potentially confounding flows obtained by lip and tongue propulsion (dart flows, DF) for normal subjects and for patients with neuromuscular disease/restrictive pulmonary syndrome and to correlate them with vital capacity and maximum insuffl...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.phm.0000197307.32537.40
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate outcomes of patients participating in inpatient rehabilitation program after left ventricular assist device (LVAD) implantation. DESIGN:Medical records of 94 patients who received LVADs between January 1, 2008, and June 30, 2010, at the Mayo Clinic in Rochester, MN, were...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000000101
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:Previous studies have shown that subthreshold electrical or mechanical noise can reduce the sensory threshold and impart short-term improvements in sensorimotor function. We undertook this study to examine the effects of combined subsensory electrical and vibratory stimulation in conjunction with exercise tr...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1097/PHM.0b013e3181ec9aa8
更新日期:2010-09-01 00:00:00
abstract:ABSTRACT:Increasing exposure to the needs of patients with chronic disability is important in fostering confidence and comfort in disability knowledge and management among medical students and residents of all disciplines. The 2013 Association of American Medical Colleges Graduation Survey of graduating medical student...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001590
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:To assess the effect of a proprioceptive dynamic posture training program on balance in osteoporotic women with kyphotic posture. DESIGN:Subjects were randomly assigned to either a proprioceptive dynamic posture training program or exercise only group. Anthropometric measurements, muscle strength, level of p...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00002060-200204000-00001
更新日期:2002-04-01 00:00:00
abstract::Wegener's granulomatosis is a multisystem disease distinguished by a triad of necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis and systemic, small vessel vasculitis. The latter can cause neurologic manifestations when the vasa nervorum are affected. A 53-yr-old ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199202000-00003
更新日期:1992-02-01 00:00:00
abstract::A combination of in vivo and in vitro analyses was performed to investigate muscular and neural adaptations of the weaker (nondominant) quadriceps femoris muscle of one healthy individual to short-term electrostimulation resistance training. The increase in maximal voluntary strength (+12%) was accompanied by neural (...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/01.phm.0000197570.03343.18
更新日期:2006-02-01 00:00:00
abstract::Moyamoya disease is a rare disorder of cerebrovascular circulation. A review of the literature failed to reveal the association of heterotopic ossification in patients with this disease; such a case is now presented. The patient described had atraumatic intracranial hemorrhage, was in a coma for a period of time, unde...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/00002060-199809000-00021
更新日期:1998-09-01 00:00:00
abstract:PURPOSE:The aim of the study was to compare the clinical, radiographic, and ultrasound findings between simple and complicated Baker's cysts. METHODS:Forty-seven knees with Baker's cysts in 45 patients with knee pain were identified from a chart review. Baker's cysts were classified as simple or complicated according ...
journal_title:American journal of physical medicine & rehabilitation
pub_type: 杂志文章
doi:10.1097/PHM.0000000000001263
更新日期:2020-01-01 00:00:00