Abstract：
:Night eating syndrome (NES) represents a delay in the circadian pattern of food intake, manifested by evening hyperphagia and/or nocturnal awakenings accompanied by ingestions of food. A neurobiological marker of NES has been implicated with the recently discovered therapeutic response to the selective serotonin reuptake inhibitor (SSRI) sertraline. This pilot SPECT (single photon emission computed tomography) study compared the serotonin transporter (SERT) uptake ratios of night eaters with those of healthy controls. Six night eaters underwent SPECT imaging using the radiopharmaceutical (123)I-ADAM. Uptake, compared with that of the cerebellum, was obtained for the midbrain, basal ganglia, and temporal lobes; uptake ratios in night eaters were compared with those of six healthy controls. Night eaters had significantly greater SERT uptake ratios in the midbrain than healthy controls. These findings, in conjunction with the therapeutic response of NES to sertraline, indicate that the serotonin system is involved in the pathophysiology of NES.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Lundgren JD,Newberg AB,Allison KC,Wintering NA,Ploessl K,Stunkard AJdoi
10.1016/j.pscychresns.2007.07.006subject
Has Abstractpub_date
2008-04-15 00:00:00pages
214-20issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(07)00147-3journal_volume
162pub_type
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