A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder.

Abstract:

OBJECTIVE:To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder. METHODS:Twelve elderly patients with bipolar I or II disorder, with evidence of mild cognitive decrements, were administered donepezil 5-10 mg daily for 3 months. Participants had cognitive and functional evaluation pre-, on-, and 3-months post donepezil administration. RESULTS:Three subjects dropped out of the study. In the remaining nine subjects, no significant effects were observed in cognitive and functional measures. Seven of the nine participants asked to resume the medication after completion of the study because of the perceived beneficial effects. CONCLUSIONS:In this small pilot study of older adults with bipolar disorder, acute treatment with donepezil was not associated with improvements in cognitive and IADL functioning. Given limitations of the study design, placebo effects could not be ruled out in the subjects who asked to resume donepezil.

authors

Gildengers AG,Butters MA,Chisholm D,Reynolds CF,Mulsant BH

doi

10.1002/gps.1962

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

693-8

issue

7

eissn

0885-6230

issn

1099-1166

journal_volume

23

pub_type

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