Abstract：
BACKGROUND:Acetyl Cholinesterase Inhibitors (AChEIs) have been in clinical use for the past five years in the UK for the symptomatic treatment of Alzheimer's disease (AD). There are few data on the patterns and predictors of response to AChEI therapy in routine clinical practice. We therefore investigated clinical variables that may distinguish between AChEI responders and non-responders. METHODS:A retrospective sample of 160 consecutive patients with dementia who were treated on clinical grounds with an AChEI was studied. Treatment response was defined in two ways: (a) A clinical response was achieved when there was no deterioration or there was an improvement on a global clinical assessment (CGI) and (b) a Mini-Mental-State-Examination (MMSE) response when there was an improvement of 2 or more MMSE points. RESULTS:A total of 62 (45%) patients achieved an MMSE response. A diagnosis of dementia with Lewy Bodies (DLB) and Parkinson's disease+Dementia (PDD) was associated with a MMSE response, as were hallucinations, and lower MMSE scores at baseline. 125 (78%) patients achieved a CGI response for which there were no clinical predictors. CONCLUSIONS:Severity of illness, a diagnosis of DLB and PDD, and presence of hallucinations at baseline were predictive of a MMSE response. Non-AD dementia and severe dementia responded equally well to AChEI treatment and results of further randomised, placebo-controlled studies are needed to clarify the role of AChEI in the treatment of these disorders.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Pakrasi S,Mukaetova-Ladinska EB,McKeith IG,O'Brien JTdoi
10.1002/gps.928subject
Has Abstractpub_date
2003-10-01 00:00:00pages
879-86issue
10eissn
0885-6230issn
1099-1166journal_volume
18pub_type
杂志文章abstract：OBJECTIVE:To investigate associations between vision impairment (VI), vision correction (VC) and depressive symptoms among middle-aged and older Chinese. METHODS:22 203 participants aged ≥45 years from China Health and Retirement Longitudinal Study 2011 to 2015 were divided into four self-reported VI categories: no VI...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5398
更新日期：2021-01-01 00:00:00
abstract：:We examined the factor structure of the 17-item Hamilton Rating Scale for Depression (HRS-D) in 206 community-dwelling elderly patients. Using principal components analysis and quartimax rotation, a four-factor structure involving all 17 items and accounting for 57.7% of the variance was desired. The factors represent...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：UNLABELLED:Data on the prevalence of and risk factors for suicide ideation among older people in developing countries is lacking. OBJECTIVE:This study aimed to estimate if dementia and other mental disorders are associated with suicide ideation among the older people controlling for demographic and other suspected ris...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4134
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVES:While a recent task force report recommended that remission from major depression be defined according to DSM criteria, most previous work has used depressive symptom rating scales. The current study sought to identify baseline factors associated with treatment outcome in major depression, diagnosed accordin...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.2485
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Most depression in older people is managed in primary care settings but can be difficult to diagnose and is often under-treated. This study examined the attitudes and practice of general practitioners in the treatment of late-life depression using antidepressant medication. METHOD:Three hundred and thirty g...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.603
更新日期：2002-04-01 00:00:00
abstract：:Family members incur substantial financial costs during the course of caring for an individual with Alzheimer's disease. Much of this cost is associated with time spent in caregiving tasks, including supervision and communication with the patient, and assisting with activities of daily living. We have previously repor...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/1099-1166(200008)15:8<680::aid-gps180>3.0.
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVE:Limited data are available on how older adults access public mental health systems. This study examines how uninsured or publicly insured older adults with severe mental illness in San Diego County initially accessed the public mental health system, as well as their subsequent use of public mental health serv...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2123
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Depression is common in Alzheimer's disease (AD; 5-35%). It is associated with increased disability, cost of care and carer burden. Exercise is known to be associated with a lower prevalence of depression across the age range but little is known about its relationship to depression in AD. AIMS:To investigat...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1278
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:Exposure to negative life events (NLEs) and neuroticism are associated with dementia. It is unknown whether neuroticism explains or modifies the association of NLEs with dementia in older Black and White Brazilians. METHODS:A total of 1747 decedents 65 years and older White and Black (11% Black and 23% Mixed...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5491
更新日期：2020-12-30 00:00:00
abstract：BACKGROUND:This study examined changes in cognitive-functional relationships in vascular dementia (VaD) over the course of one year. METHODS:Twenty-four patients with probable VaD were administered the Dementia Rating Scale (DRS). Caregivers completed an informant-based measure of instrumental (IADL) and basic activit...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1556
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence of body image dysfunction in a cohort of older, inpatient women, and to examine any associated health or sociodemographic factors. METHODS:In this cross-sectional, observational study, 50 older women admitted to a subacute hospital completed the Body Shape Questionnaire (BSQ-34),...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5233
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Based on the hypothesis that declarative memory and navigation ability depend on hippocampal integrity, and the fact that declarative memory declines early in Alzheimer's disease (AD), the authors suggest that topographical disorientation (TD) will be an early manifestation of AD. SUBJECTS AND METHODS:Patie...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1081
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to explore the effects of demographic variables on Stroop Color and Word Test (SCWT) performance in an educationally diverse elderly population and to provide normative information. METHODS:SCWT was administered to 564 community-dwelling volunteers aged 60-90 years with an educa...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2027
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To evaluate variables associated with quality of life (QOL) in dementia residents in a long-term care facility using a recently standardized and validated dementia-specific QOL scale (ADRQL). METHOD:A cross-sectional, case-control design was employed using validated scales to assess dementia-related symptoma...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(200002)15:2<181::aid-gps96
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:It is unknown to what extent depression and cognitive dysfunction are related in subjects with dementia. A limitation of earlier studies is that only general measures of depression have been studied. METHODS:In a sample of 60 subjects with dementia according to DSM-III-R criteria depressive symptoms were di...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.1315
更新日期：2005-05-01 00:00:00
abstract：INTRODUCTION:Short-form versions of the Montreal Cognitive Assessment (SF-MoCA) are increasingly used to screen for dementia in research and practice. We sought to collate evidence on the accuracy of SF-MoCAs and to externally validate these assessment tools. METHODS:We performed systematic literature searching across...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5162
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the DementiAbility Methods: The Montessori Way (DMMW) on agitation in long-term care home residents with dementia. The activities using the DMMW are hypothesized to reduce agitation in terms of its frequency and disruptiveness to greater extent than structured social activities as...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5063
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:Older adults with psychiatric disorders have a substantially lower life expectancy than age-matched controls. Knowledge of risk factors may lead to targeting treatment and interventions to reduce this gap in life expectancy. In this study, we investigated whether frailty independently predicts mortality in o...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5278
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:Physical symptoms are known to be associated with late life depression both cross-sectionally and over time. We attempted to determine if self-reported shortness of breath (SoB) is associated with depressive symptoms at long-term (3-year) follow-up in a community sample of older (65+) adults. METHODS:A samp...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.2477
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:The oldest old are prone to develop delirium. Studies into risk factors for delirium have been carried out predominantly in younger age groups. The aim of this population-based follow-up study was to investigate the risk factors for delirium requiring medical attention and subsequent prognosis in the non-dem...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.356
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydro...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2358
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:Posttraumatic stress disorder (PTSD) is a common and disabling condition following a traumatic event. Despite its high prevalence rates, relatively little is known about the manifestation and course of the disorder in older adults. Moreover, there has been little evaluation of the efficacy of psychotherapeuti...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.2725
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:To measure depressive symptomatology in a largely illiterate elderly population in India, using a new Hindi version of the Geriatric Depression Scale (GDS-H), and to examine its distribution and associations with age, gender, literacy, cognitive impairment and functional impairment. DESIGN:A Hindi version of...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Alzheimer's family caregivers suffer from psychological and physical morbidity associated with the care of the Alzheimer's patient. The objectives of the study were to compare stress and psychological morbidity between family caregivers of Alzheimer's disease patients and family caregivers of aged non-dement...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/(sici)1099-1166(199909)14:9<701::aid-gps5>
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between regular physical activity and the risk of incident dementia in older Japanese adults. METHODS:This was a retrospective cohort study performed in Okayama City, Japan. Overall, 51 477 older Japanese adults were followed from 2008 to 2014. A health checkup questionnaire was u...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5135
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To review and summarise published data on medication errors in older people with mental health problems. METHODS:A systematic review was conducted to identify studies that investigated medication errors in older people with mental health problems. MEDLINE, EMBASE, PHARMLINE, COCHRANE COLLABORATION and PsycIN...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.1943
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To examine the contribution of medication adherence to 12-month depression scores in the context of other psychosocial and clinical predictors of depression in a sample of older adults treated for depression. METHODS:Secondary analysis of a prospective cohort study involving 241 older patients undergoing dep...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1852
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVES:Family dementia caregivers are at high risk of depression and burnout. We assessed the feasibility of Central Meditation and Imagery Therapy for Caregivers (CMIT-C), a novel 8-week group meditation and guided imagery group therapy program, for dementia caregivers reporting stress because of caregiving respon...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4076
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVES:To assess the association between early parental death and the risk of dementia in adult life and to examine the risk factors associated with early parental death in people with and without dementia. METHODS/DESIGN:A population-based case-control study of a sample of 65 997 participants from the Survey of H...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5328
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study is to analyze modifiable factors related to agitation of nursing home residents with dementia. METHODS:Relationship of agitation with three modifiable factors (depression, psychosis, and pain) was explored using longitudinal Minimum Data Set (MDS) information from 2032 residents of Dutc...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2800
更新日期：2012-07-01 00:00:00
