Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease.

Abstract:

INTRODUCTION:Gliadin proteins play a key role in the pathogenesis of celiac disease; however, as a screen for celiac disease, anti-gliadin antibody testing has been replaced by the more sensitive and specific serological assays for transglutaminase autoantibodies (TGAA). A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high sensitivity and specificity. METHODS:Sera were collected prospectively from children with an increased risk for celiac disease as part of an ongoing study at Denver, and studied for the development of celiac autoimmunity. We investigated the high-performance DGP antibody assay in 50 TGAA-positive children both before the development of celiac autoimmunity and following the institution of a gluten-free diet to determine the relationship of DGP antibodies to TGAA. TGAA were measured by an in-house radioassay. RESULTS:DGP antibodies and TGAA parallel each other over the period of years children were studied. DGP antibodies resolved sooner than TGAA in subjects on a gluten-free diet. DGP antibodies appeared earlier than TGAA in 9 children. CONCLUSIONS:Measuring DGP antibodies may be more useful than TGAA in monitoring children on a gluten-free diet. DGP antibodies can precede the appearance of TGAA in some at-risk children.

authors

Liu E,Li M,Emery L,Taki I,Barriga K,Tiberti C,Eisenbarth GS,Rewers MJ,Hoffenberg EJ

doi

10.1097/MPG.0b013e31806c7b34

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

293-300

issue

3

eissn

0277-2116

issn

1536-4801

pii

00005176-200709000-00004

journal_volume

45

pub_type

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