Golimumab Therapy in Six Patients With Severe Pediatric Onset Crohn Disease.

Abstract:

:Anti-tumor necrosis factor-alpha (TNF-α) blockade is so far the most effective therapy for extensive pediatric Crohn disease (CD), but loss of response is frequently encountered. We describe here the use of golimumab (Simponi) in 6 pediatric CD patients with antibody formation/loss of response to infliximab and adalimumab. Most patients had undergone surgery but had poor disease control. After introduction of golimumab, the levels of inflammatory markers and fecal calprotectin declined at first, but the response was not sustained. Each patient needed dose escalation of golimumab from 4 to 2 week intervals, to maintain response and to increase trough levels. Importantly, most patients were able to attend school when undergoing golimumab therapy. As with other anti-TNFα drugs, follow-up of drug levels is advisable. Although golimumab therapy failed in most patients, it is an alternate treatment option in pediatric patients with severe CD. The therapeutic response, however, is suboptimal in anti-TNFα exposed patients.

authors

Merras-Salmio L,Kolho KL

doi

10.1097/MPG.0000000000001165

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

344-7

issue

3

eissn

0277-2116

issn

1536-4801

journal_volume

63

pub_type

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