Evaluation of a daily dose of 25 micrograms vitamin K1 to prevent vitamin K deficiency in breast-fed infants.

Abstract:

:Vitamin K prophylaxis is recommended to prevent the hazard of hemorrhage caused by vitamin K deficiency in young infants. A single administration after birth seems inadequate to completely prevent late haemorrhagic disease in breast-fed infants. The preventive effect of a daily oral dose of 25 micrograms vitamin K1, which is comparable to about half the dose ingested by formula-fed infants, was evaluated in 58 breast-fed infants. No clinical or biochemical signs of vitamin K deficiency occurred; PIVKA-II was not detectable, and vitamin K1 concentrations were moderately elevated. Vitamin K1 levels were negatively correlated with the number of hours elapsed since the most recent gift. Twenty to 28 h after the administration, median (P10-P90) levels were 1,262 (267-4,328), 1,072 (293-3,427), and 882 (329-2,070) pg/ml at 4, 8, and 12 weeks of age, respectively. Vitamin K1 levels in formula-fed infants (n = 10) were around 7,000 pg/ml. In conclusion, daily supplementation of 25 micrograms vitamin K1 can be recommended for breast-fed infants to prevent vitamin K deficiency beyond the neonatal period.

authors

Cornelissen EA,Kollée LA,van Lith TG,Motohara K,Monnens LA

doi

10.1097/00005176-199304000-00014

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

301-5

issue

3

eissn

0277-2116

issn

1536-4801

journal_volume

16

pub_type

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