C-ANCA/proteinase 3-positive colitis in children: a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation?

Abstract:

AIM:Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context. METHODS:Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype. RESULTS:The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P < 0.05). None had vasculitis features at diagnosis nor during follow-up. CONCLUSIONS:This pilot study demonstrates significant clinical differences between the PR3-ANCA-positive and -negative IBD subset.

authors

Van Biervliet S,Bonroy C,Vande Velde S,De Bruyne R,Van Winckel M,Peeters H,Delanghe J,Stove V,De Vos M

doi

10.1097/MPG.0b013e31829d4e9e

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

489-92

issue

4

eissn

0277-2116

issn

1536-4801

journal_volume

57

pub_type

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