Abstract:
BACKGROUND:Vitamin D deficiency is common in older people and may increase risk of falls and fracture. Hospital inpatients are at particular risk of falling. Previous studies suggest that vitamin D improves neuromuscular function and reduces falls. OBJECTIVE:To determine whether routine supplementation with vitamin D plus calcium reduces numbers of fallers and falls in a cohort of hospital admissions while they are inpatients. DESIGN:Randomised, double-blind, controlled study. PARTICIPANTS:two hundred and five acute admissions >65 years to a geriatric medical unit. METHODS:Patients were randomised to intervention of daily vitamin D 800 iu plus calcium 1,200 mg or control group of daily calcium 1,200 mg, until discharge or death. RESULTS:Baseline characteristics were similar in both groups with a median age 84 years and a median length of stay = 30 days (IQR 14.75-71.00). In a pre-selected sub-group (54/205 participants), median admission vitamin D level = 22.00 nmol/l (IQR 15.00-30.50). This did not significantly increase in the treatment versus control group. Median study drug adherence = 88%, with no significant difference between study groups (Mann-Whitney: P = 0.711). Although there were fewer fallers in the vitamin D cohort, this did not reach statistical significance (vitamin D: calcium = 36:45 fallers; RR 0.82 (CI 0.59-1.16). Neither the mean number of falls (vitamin D: calcium = 1.040:1.155; Mann-Whitney P = 0.435) or time to first fall (Log-rank test P = 0.377) differed between groups. CONCLUSIONS:In a population of geriatric hospital inpatients, vitamin D did not reduce the number of fallers. Routine supplementation cannot be recommended to reduce falls in this group.
journal_name
Age Ageingjournal_title
Age and ageingauthors
Burleigh E,McColl J,Potter Jdoi
10.1093/ageing/afm087subject
Has Abstractpub_date
2007-09-01 00:00:00pages
507-13issue
5eissn
0002-0729issn
1468-2834pii
afm087journal_volume
36pub_type
杂志文章,随机对照试验相关文献
AGE AND AGEING文献大全abstract:BACKGROUND:up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian a...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afs150
更新日期:2012-11-01 00:00:00
abstract::An outline is given of simple urodynamic investigations applicable to elderly subjects. The type of patient presenting primarily to geriatric departments with urinary incontinence, whose management is aided by such studies, is described under various clinical groupings. The requirement for urodynamic studies and the b...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/8.1.41
更新日期:1979-02-01 00:00:00
abstract::To learn whether the percentage of time spent at different functional levels varies as a function of age, we studied 44 older (mean age 70 years) and 46 younger (mean age 27 years) urban, community-dwelling volunteers who participated in a study of normative ageing of the cardiovascular system. Each subject completed ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/23.1.34
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Diabetes management has not been evaluated in French nursing homes (NHs) for 10 years. OBJECTIVES:The present study aimed to compare the management of diabetes with guidelines in older patients living in NHs. DESIGN:Observational, retrospective and multicentre study carried out in 13 NH in the Cote d'Or re...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afaa051
更新日期:2020-08-24 00:00:00
abstract:OBJECTIVES:to analyse socio-demographic differences in the onset and progression of disability. DESIGN:analysis of a cohort of people aged 55-69 in 1988-9 and in 1994. SUBJECTS:a representative sample of 3543 adults. METHODS:we measured severity of disability at baseline and follow-up. We analysed variations in inci...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/29.2.149
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:frailty is a dynamic condition for which a range of interventions are available. Health state utilities are values that represent the strength of an individual's preference for specific health states, and are used in economic evaluation. This is a topic yet to be examined in detail for frailty. Likewise, lit...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afaa166
更新日期:2020-09-16 00:00:00
abstract:Background:there is growing consensus around the importance of population level approaches which seek to improve public knowledge and awareness of dementia. Aim:to assess knowledge of the relationship between dementia and ageing, and of the risk and protective factors associated with it, among the general public in Ir...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afx082
更新日期:2017-09-01 00:00:00
abstract::Resuscitation decisions during the first 6 weeks were analysed for 97 admissions to a psychogeriatric ward of a general teaching hospital. Seventy-seven patients (79%) had a written 'do not resuscitate' (DNR) order on admission and 74 patients (875) had a written DNR order after 6 weeks. Morbidity was assessed with a ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/25.3.234
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:To determine the presentation, course and duration of delirium in hospitalized older people. DESIGN:Observational cohort study. SETTING:Inpatient surgical and medical wards at a university hospital. PARTICIPANTS:432 people over the age of 65. MEASUREMENTS:All participants were screened daily for confusio...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/26.3.169
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:the data concerning the predictive role of oxidised LDL (ox-LDL) in all-cause mortality are scarce. We investigated whether circulating ox-LDL would stand out as a risk factor of total mortality in the elderly. Study subjects, design and methods: a total of 1,260 elderly inhabitants (533 men, 7...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afs074
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:There are conflicting data on the association between Helicobacter pylori (HP) infection and cardiovascular diseases. AIM:To determine if there is an association between gastric HP infection and atherosclerosis of cerebral or peripheral arteries in elderly subjects. METHODS:90 dyspeptic elderly subjects ha...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/28.4.367
更新日期:1999-07-01 00:00:00
abstract::The General Medical Council (GMC) provides a core curriculum for all medical degrees in the UK. However, these guidelines do not provide in-depth, specific learning outcomes for the various medical specialties. Recognising our ageing population, the British Geriatrics Society in 2013 published their own supplementary ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw003
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:residential aged care facility (RACF) resident numbers are increasing. Residents are frequently frail with substantial co-morbidity, functional and cognitive impairment with high susceptibility to acute illness. Despite living in facilities staffed by health professionals, a considerable proportion of reside...
journal_title:Age and ageing
pub_type: 杂志文章,评审
doi:10.1093/ageing/afu117
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:to provide evidence for predictors of recovery in instrumental activities of daily living (IADLs) among disabled older people living in the community. DESIGN:MRC CFAS recruited a sample of 13,004 individuals aged 65 years and above from five communities in the UK. Participants underwent a baseline interview ...
journal_title:Age and ageing
pub_type: 杂志文章,多中心研究
doi:10.1093/ageing/afp128
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:transcatheter aortic valve implantation (TAVI) has emerged as an alternative to surgical aortic valve replacement for patients with severe aortic stenosis considered inoperable or at high operative risk, but the long-term outcome remains unknown. HYPOTHESIS:we assessed the 4-year clinical and echocardiograp...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afw038
更新日期:2016-05-01 00:00:00
abstract::A sample of 761 subjects 70 years and over was drawn from general-practice records of a rural township. Each subject was assessed and followed for 1 year to determine the incidence of and factors related to falls. The fall rate (number of falls per 100 person-years) increased from 47 for those aged 70-74 years to 121 ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/19.2.136
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Cognitive health expectancy estimates the proportion of the lifespan that is lived in good cognitive health at the population level. A number of cardiovascular diseases have been identified to be risk factors for cognitive decline and dementia including diabetes, stroke, heart diseases and hypertension. The ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afaa111
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVES:this study aimed to investigate the construct validity and responsiveness of performance-based and self-reported measures of strength, mobility and balance after hip fracture. DESIGN:secondary analysis of clinical trial data. SUBJECTS:a total of 148 older people undergoing hip fracture rehabilitation. MET...
journal_title:Age and ageing
pub_type: 杂志文章,随机对照试验
doi:10.1093/ageing/afs090
更新日期:2012-09-01 00:00:00
abstract::This paper is an exploratory attempt to examine international differences in the proportion of old people living in non-private households. The aim of the study was to provoke further discussion of the role which institutions play in the care of the elderly in various settings and to examine the effect of certain demo...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/13.3.129
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVES:to determine the prevalence of vertebral fractures and their risk factors in geriatric patients. DESIGN:prospective cohort study. SETTING:teaching hospital in Amsterdam, The Netherlands. SUBJECTS:three hundred and three geriatric patients, who had their first visit at a diagnostic day hospital between Apr...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afr174
更新日期:2012-03-01 00:00:00
abstract::The contribution of the elderly to the workload of a combined consultative District Hospital Gastroenterology Clinic has been studied over a 12-year period. The elderly group comprise 24% of the total referrals with a gradually increasing trend over successive years. The service implications are discussed and the main...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/17.1.49
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:observational studies do not always find positive associations between physical activity and muscle strength despite intervention studies consistently showing that exercise improves strength in older adults. In previous analyses of the MRC National Survey of Health and Development (NSHD), the 1946 British ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/aft124
更新日期:2013-11-01 00:00:00
abstract::Among 352 residents of a home for the elderly, who were fully mobile and devoid of most predisposing factors for bacteriuria, 19% of men and 27% of women had two positive cultures within two months. Positive conversion at one year among men and women negative at entry was 11% and 23% respectively, negative conversion ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/11.3.169
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVES:to compare the cost effectiveness of post-acute care for older people provided in community hospitals with general hospital care. DESIGN:cost-effectiveness study embedded within a randomised controlled trial. SETTING:seven community hospitals and five general hospitals at five centres in the midlands and n...
journal_title:Age and ageing
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/ageing/afn120
更新日期:2008-09-01 00:00:00
abstract::This paper describes how a sample of elderly people were identified from the electoral register using an initial postal screen, and reports a technique that was used to increase the response to the screen. ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/16.2.119
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:in recent years, the NHS has been accused of ageism frequently and from many fronts. Previous studies have shown that the number of critical care beds in the UK is inadequate to meet the needs of the population. This study asks whether there is discrimination against older people in access to these critical ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/32.4.382
更新日期:2003-07-01 00:00:00
abstract:AIM:to examine the degree of medical treatment wanted by nursing home residents, their relatives and staff members should the resident develop a serious and life-threatening disease and to analyse the degree of agreement between the wishes of these parties. DESIGN:an epidemiological, descriptive cross-sectional study....
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/26.2.133
更新日期:1997-03-01 00:00:00
abstract::The present study was undertaken to define the hormonal response to thyroid-releasing hormone (TRH) further in a large, healthy, ambulatory elderly group. Seventy-seven subjects over 60 years old, 30 males (MA) and 47 females (FA), and control subjects, 22 males (MC) and 42 females (FC) were studied. No difference in ...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/16.6.345
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common. These may not always be reported in the literature. CASE REPORT:A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigat...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/afh015
更新日期:2004-03-01 00:00:00
abstract::Sway has been measured by Wright's Ataxiameter in 151 frail elderly and five young subjects, and compared with various sensory modalities. There is a close relationship between increased sway and impaired vibration sense in the legs. No correlations emerged with proprioception but this may reflect the imprecision of t...
journal_title:Age and ageing
pub_type: 杂志文章
doi:10.1093/ageing/11.1.1
更新日期:1982-02-01 00:00:00