Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study.

Abstract:

BACKGROUND:up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian adults surveyed in 1978. METHODS:a community survey of 2,194 adults aged 40+ years in Busselton, Western Australia in 1978 with mortality follow-up to 2001. Cox regression models were used to investigate the relationships of haemoglobin as a continuous measure and anaemia by WHO criteria (women <12 g/dl (7.5 mmol/l); men <13 g/dl (8.1 mmol/l)) with all-cause, cardiovascular and cancer mortality. RESULTS:anaemia was predominantly mild (>10 g/dl) and normocytic. There was an increased risk of death from all causes and from cancer for men with low haemoglobin. Cancers were predominantly of the prostate and genito-urinary organs, and to a lesser extent the gastrointestinal tract. There was no increased risk of all cause or cancer death in women. CONCLUSION:mild, normocytic anaemia is associated with survival reductions in middle-aged and older men, where it often occurs with prostate, gastrointestinal and other cancers, and should be investigated to exclude treatable causes.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Chalmers KA,Knuiman MW,Divitini ML,Bruce DG,Olynyk JK,Milward EA

doi

10.1093/ageing/afs150

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

759-64

issue

6

eissn

0002-0729

issn

1468-2834

pii

afs150

journal_volume

41

pub_type

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