Persistent pain is a risk factor for frailty: a systematic review and meta-analysis from prospective longitudinal studies.

Abstract:

Background:pain is prevalent in frail older adults; however, the association of pain and frailty has not been evaluated yet by a systematic assessment of prospective longitudinal studies. Objective:we aimed to assess the association of persistent pain as a risk factor for frailty incidence, using data from longitudinal studies in a systematic review and meta-analysis. Methods:publications were identified using a systematic search on PubMed, Embase, Cochrane Library and clinicaltrials.gov databases from inception to October 2017. Since heterogeneity across studies was high, we used random-effects meta-analysis to calculate the pooled relative risk for the association between persistent pain and the incidence of frailty. We investigated sources of heterogeneity among studies using meta-regression and stratified analyses. Results:we included five prospective longitudinal studies with 13,120 participants (46% women, mean age from 59 to 85 years old). Participants with persistent pain at baseline had twice the risk of developing frailty during the follow-up (pooled RR = 2.22, 95% CI = 1.14-4.29). No variables were related to study heterogeneity in sensitivity analyses. Conclusion:persistent pain was a risk factor for the development of frailty in a meta-analysis of longitudinal studies. Better understanding of the association between pain and frailty with proper evaluation of potential confounders could allow the development of targeted interventions.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Saraiva MD,Suzuki GS,Lin SM,de Andrade DC,Jacob-Filho W,Suemoto CK

doi

10.1093/ageing/afy104

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

785-793

issue

6

eissn

0002-0729

issn

1468-2834

pii

5056943

journal_volume

47

pub_type

杂志文章,meta分析
  • Confirming long-stay status.

    abstract::This paper discusses an assessment procedure for the formal identification of patients requiring long-stay geriatric care. It was introduced immediately prior to the reorganization of geriatric in-patient care at St Pancras Hospital which saw the abolition of mixed wards of acute, rehabilitation, and long-stay patient...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.1.13

    authors: Golding R,Lugon M,Hodkinson HM

    更新日期:1987-01-01 00:00:00

  • The effect of a vinyl floor surface and a carpeted floor surface upon walking in elderly hospital in-patients.

    abstract::Fifty-eight elderly hospital patients walked along a 10-m length of carpeted corridor and a 10-m length of vinyl-tiled corridor. Gait speed and step length were significantly greater on the carpeted than on the vinyl surface. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/15.2.119

    authors: Willmott M

    更新日期:1986-03-01 00:00:00

  • Duodenal ulcer disease in the elderly: a retrospective study.

    abstract::A retrospective study was performed of 163 patients aged 65 years and over with a diagnosis of duodenal ulceration admitted to one Health District over a period of six years. Eighty per cent of the patients were admitted with acute complications, 50% bled and 30% were perforated. A large proportion of these patients w...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/14.4.225

    authors: Watson RJ,Hooper TL,Ingram G

    更新日期:1985-07-01 00:00:00

  • Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial.

    abstract:BACKGROUND:cranberry juice is often given to older people in hospital to prevent urinary tract infection (UTI), although there is little evidence to support its use. OBJECTIVE:to assess whether cranberry juice ingestion is effective in reducing UTIs in older people in hospital. DESIGN:randomised, placebo-controlled, ...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/afi101

    authors: McMurdo ME,Bissett LY,Price RJ,Phillips G,Crombie IK

    更新日期:2005-05-01 00:00:00

  • Plasma paroxonase activity in old age.

    abstract::Genetic factors are known to be of importance in determining the rate of biotransformation of foreign compounds in the liver. Adverse reactions to drugs are increased and pharmacokinetic parameters altered with age. In the present study, the effect of age on plasma paroxonase activity is studied. Paroxonase is a hepat...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/6.2.89

    authors: Playfer JR,Powell C,Evans DA

    更新日期:1977-05-01 00:00:00

  • Circumstances and consequences of falls experienced by a community population 70 years and over during a prospective study.

    abstract::A sample of 761 subjects 70 years and over was drawn from general-practice records of a rural township. Each subject was assessed and followed for 1 year to determine the incidence of and factors related to falls. The fall rate (number of falls per 100 person-years) increased from 47 for those aged 70-74 years to 121 ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/19.2.136

    authors: Campbell AJ,Borrie MJ,Spears GF,Jackson SL,Brown JS,Fitzgerald JL

    更新日期:1990-03-01 00:00:00

  • Doege-Potter syndrome: hypoglycaemic coma in a 90-year old due to a solitary fibrous tumour.

    abstract::Solitary fibrous tumour of the pleura (SFTP) is a rare primary tumour of the pleura associated with 4% of cases with a paraneoplastic hypoglycaemia, termed Doege-Potter syndrome (DPS). We report a case of DPS presenting with severe coma in a 90-year-old woman. The cause was a malignant SFTP treated with surgical resec...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw221

    authors: Avramenko A,Lahjibi-Paulet H,Gibault L,Roussel A,Grand B,Le Pimpec-Barthes F

    更新日期:2017-05-01 00:00:00

  • Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.

    abstract:BACKGROUND/OBJECTIVES:to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. DESIGN:a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft191

    authors: Werner KB,Elmståhl S,Christensson A,Pihlsgård M

    更新日期:2014-05-01 00:00:00

  • Review: xerostomia: a symptom which acts like a disease.

    abstract::This review considers the changes in salivary glands associated with ageing and concludes that there is no evidence to show that xerostomia is likely to result from the ageing process alone. The four main factors causing xerostomia are presented and it can be seen that the condition is a side-effect of diseases and th...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/25.5.409

    authors: Ettinger RL

    更新日期:1996-09-01 00:00:00

  • The value of specialist clinical assessment of older people prior to entry to care homes.

    abstract:OBJECTIVE:to ascertain the value of employing a specialist clinician's contribution to the assessment of older people prior to care home entry. DESIGN:randomised controlled trial. METHOD:256 older people at risk of care home entry were randomly allocated to either a control group, who received the usual care manageme...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/afh007

    authors: Challis D,Clarkson P,Williamson J,Hughes J,Venables D,Burns A,Weinberg A

    更新日期:2004-01-01 00:00:00

  • The prevalence of faecal incontinence in older people living at home.

    abstract:BACKGROUND:faecal incontinence affects quality of life and causes caregiver strain. Patients are often reluctant to seek help because of embarrassment and perceived lack of effective treatment. Persisting faecal soiling may lead to unwanted and premature institutionalization. OBJECTIVE:to ascertain the prevalence of f...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/30.6.503

    authors: Edwards NI,Jones D

    更新日期:2001-11-01 00:00:00

  • Increasing delirium skills at the front door: results from a repeated survey on delirium knowledge and attitudes.

    abstract:BACKGROUND:delirium is under-recognised in comparison to other common and serious acute disorders. A 2006 survey of UK junior doctors (not undertaking specialist training) identified poor knowledge of the diagnostic criteria and treatment of delirium. We hypothesised that increased prominence accorded to delirium in th...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw066

    authors: Jenkin RP,Al-Attar A,Richardson S,Myint PK,MacLullich AM,Davis DH

    更新日期:2016-07-01 00:00:00

  • Preventing delirium in an acute hospital using a non-pharmacological intervention.

    abstract:BACKGROUND:delirium is a clinical syndrome associated with multiple short and long-term complications and therefore prevention is an essential part of its management. This study was designed to assess the efficacy of multicomponent intervention in delirium prevention. METHODS:a total of 287 hospitalised patients at in...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/afs060

    authors: Martinez FT,Tobar C,Beddings CI,Vallejo G,Fuentes P

    更新日期:2012-09-01 00:00:00

  • Drug compliance amongst psychiatric day hospital attenders.

    abstract::Drug compliance was assessed amongst all 91 patients attending a psychogeriatric day hospital during July 1988. Of the 86 patients taking medication, the 57 functionally and 29 organically ill patients were interviewed at home, the latter with their carers. A disparity in results was shown when compliance was measured...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/19.3.191

    authors: Rosenvinge HP,Groarke EP,Bradshaw JW

    更新日期:1990-05-01 00:00:00

  • Combined resistance and balance-jumping exercise reduces older women's injurious falls and fractures: 5-year follow-up study.

    abstract:BACKGROUND AND OBJECTIVE:previously, a randomised controlled exercise intervention study (RCT) showed that combined resistance and balance-jumping training (COMB) improved physical functioning and bone strength. The purpose of this follow-up study was to assess whether this exercise intervention had long-lasting effect...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/afv064

    authors: Karinkanta S,Kannus P,Uusi-Rasi K,Heinonen A,Sievänen H

    更新日期:2015-09-01 00:00:00

  • Central but not peripheral fat mass percentage is associated with blood pressure components in the elderly.

    abstract:BACKGROUND:the human body composition changes with advances in age. Particularly, the central fat amount increases. Because the central fat mass is a cardiovascular risk factor, we investigated whether in an elderly population, fat mass (measured at different bodily locations) is associated with peripheral and central ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs056

    authors: van Dijk S,van den Meiracker A,van der Cammen T,Mattace Raso F,van der Velde N

    更新日期:2012-07-01 00:00:00

  • Evaluation of a nurse-led falls prevention programme versus usual care: a randomized controlled trial.

    abstract:OBJECTIVE:to evaluate a nurse-led management plan and care pathway for older people discharged from an Accident and Emergency Department after a fall. DESIGN:randomized controlled trial. SETTING:a large teaching hospital. SUBJECTS:348 consecutive patients aged 65 or over attending the Accident and Emergency Departme...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/31.3.203

    authors: Lightbody E,Watkins C,Leathley M,Sharma A,Lye M

    更新日期:2002-05-01 00:00:00

  • Contribution of the elderly to a district hospital combined gastroenterology clinic.

    abstract::The contribution of the elderly to the workload of a combined consultative District Hospital Gastroenterology Clinic has been studied over a 12-year period. The elderly group comprise 24% of the total referrals with a gradually increasing trend over successive years. The service implications are discussed and the main...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/17.1.49

    authors: Purkayastha SK,Salter RH,Holmes KM

    更新日期:1988-01-01 00:00:00

  • Quantification of proteinuria: a re-evaluation of the protein/creatinine ratio for elderly subjects.

    abstract::The difficulties of 24-hour urine collection are well recognized, especially for elderly people for whom a means of estimating protein excretion from a single casual unit sample would be preferable. We compared measurement of total urinary protein estimated by the protein/creatinine ratio with 24-h urine collection an...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/22.6.443

    authors: Mitchell SC,Sheldon TA,Shaw AB

    更新日期:1993-11-01 00:00:00

  • Confusion ratings and abbreviated mental test performance: a comparison.

    abstract::Ninety-nine residents, 10% of the total population of elderly in Part III accommodation in Newcastle upon Tyne, were examined for the presence of psychiatric disorder, tested for cognitive impairment, and rated for the presence of confusion. Those allocated a diagnosis of dementia were most impaired and confused, and ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/15.3.139

    authors: Vardon VM,Blessed G

    更新日期:1986-05-01 00:00:00

  • Warfarin sensitivity: be aware of genetic influence.

    abstract:BACKGROUND:avoidance of over anticoagulation in response to warfarin therapy would reduce risk of associated bleeding. SUBJECTS:two elderly patients with venous thromboembolism exhibited extreme anticoagulant response to warfarin. Both were noted to have variant CYP2C9 alleles, which reduce the metabolic capacity of c...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/32.2.226

    authors: Khan T,Kamali F,Daly A,King B,Wynne HA

    更新日期:2003-03-01 00:00:00

  • Development of the nursing home Resident Assessment Instrument in the USA.

    abstract:BACKGROUND:the nursing home Resident Assessment Instrument (RAI) includes a set of core assessment items, known as the Minimum Data Set (MDS), for assessment and care screening and more detailed Resident Assessment Protocols in 18 areas that represent common problem areas or risk factors for nursing home residents. Its...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/26.suppl_2.19

    authors: Hawes C,Morris JN,Phillips CD,Fries BE,Murphy K,Mor V

    更新日期:1997-09-01 00:00:00

  • High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

    abstract:OBJECTIVE:to explore the relationship between blood lipids/lipoproteins and cognitive function in the Chinese oldest-old. DESIGN:multivariate statistical analysis using cross-sectional data. SETTING:community-based setting in longevity areas in China. SUBJECTS:eight hundred and thirty-six subjects aged 80 and older ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs033

    authors: Yin ZX,Shi XM,Kraus VB,Fitzgerald SM,Qian HZ,Xu JW,Zhai Y,Sereny MD,Zeng Y

    更新日期:2012-09-01 00:00:00

  • Institutionalization and the elderly: international comparisons.

    abstract::This paper is an exploratory attempt to examine international differences in the proportion of old people living in non-private households. The aim of the study was to provoke further discussion of the role which institutions play in the care of the elderly in various settings and to examine the effect of certain demo...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/13.3.129

    authors: Grundy E,Arie T

    更新日期:1984-05-01 00:00:00

  • The association of ageing with calcium active hormone status in men.

    abstract::We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p < 0.01) together with a parallel increase in urinary (r = 0.46, p < 0.05) and nephrogenic cAMP (r = 0.63, p < 0....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.2.127

    authors: Ravaglia G,Forti P,Pratelli L,Maioli F,Scali CR,Bonini AM,Tedioli S,Marasti N,Pizzoferrato A,Gasbarrini G

    更新日期:1994-03-01 00:00:00

  • Health-related quality of life and antihypertensive medication adherence among older adults.

    abstract:PURPOSE:health-related quality of life (HRQOL) is an important psycho-social characteristic which may impact an individual's ability to manage their chronic disease. We examined the association between HRQOL and antihypertensive medication adherence in older adults. METHODS:participants were part of a cohort study of ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afq040

    authors: Holt EW,Muntner P,Joyce CJ,Webber L,Krousel-Wood MA

    更新日期:2010-07-01 00:00:00

  • Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials.

    abstract:OBJECTIVE:to review systematically the range of case definitions and methods used to measure falls in randomised controlled trials. DESIGN/METHODS:a Cochrane review of fall prevention interventions was used to identify fall definitions in published trials. Secondary searches of various databases were used to identify ...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afi218

    authors: Hauer K,Lamb SE,Jorstad EC,Todd C,Becker C,PROFANE-Group.

    更新日期:2006-01-01 00:00:00

  • Functional profiles of healthy older persons.

    abstract::To learn whether the percentage of time spent at different functional levels varies as a function of age, we studied 44 older (mean age 70 years) and 46 younger (mean age 27 years) urban, community-dwelling volunteers who participated in a study of normative ageing of the cardiovascular system. Each subject completed ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.1.34

    authors: Ashworth JB,Reuben DB,Benton LA

    更新日期:1994-01-01 00:00:00

  • Effect of the COVID-19 Lockdown on Disease Recognition and Utilization of Healthcare Services in the Older Population in German: A Cross-sectional Study.

    abstract:BACKGROUND:There is little evidence about the utilization of healthcare services and disease recognition in the older population, which was urged to self-isolate during the COVID-19 lockdowns. OBJECTIVES:We aimed to describe the utilization of physician consultations, specialist referrals, hospital admissions, and the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa260

    authors: Michalowsky B,Hoffmann W,Bohlken J,Kostev K

    更新日期:2020-11-17 00:00:00

  • Four-year clinical results of transcatheter self-expanding Medtronic CoreValve implantation in high-risk patients with severe aortic stenosis.

    abstract:BACKGROUND:transcatheter aortic valve implantation (TAVI) has emerged as an alternative to surgical aortic valve replacement for patients with severe aortic stenosis considered inoperable or at high operative risk, but the long-term outcome remains unknown. HYPOTHESIS:we assessed the 4-year clinical and echocardiograp...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw038

    authors: Thomopoulou S,Vavuranakis M,Karyofyllis P,Kariori M,Karavolias G,Balanika M,Smyrli A,Stefopoulos C,Sbarouni E,Moldovan C,Khoury M,Stefanadis C,Voudris V

    更新日期:2016-05-01 00:00:00