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Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus.

Abstract：

:During heart development, various signaling cascades are tightly regulated in a stage- and region-dependent manner. Vascular endothelial growth factor (VEGF) is one of the important molecules required for both vascular development and cardiac morphogenesis. VEGF receptors are present in the embryonic heart, so we focused on heart formation in VEGF-over-expressing Xenopus embryos. Over-expression of VEGF(170) caused disorganized vessels, while the expression of an endothelial marker, Tie-2, was increased. The embryo's heart was distinctly larger than that of control, and showed abnormal morphology. Histological analysis of these embryos showed failure of heart looping. In situ hybridization with Hand-1, which controls intrinsic morphogenetic pathways, revealed that the expression level of Hand-1 was decreased in the heart region. These results suggest that increased VEGF(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis. VEGF expression level may be important in heart morphology during embryonic development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nagao K,Taniyama Y,Koibuchi N,Morishita R

doi

10.1016/j.bbrc.2007.05.140

subject

Has Abstract

pub_date

2007-08-03 00:00:00

pages

431-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01074-1

journal_volume

359

pub_type

杂志文章

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