Lamivudine monoprophylaxis for liver transplant recipients with non-replicating hepatitis B virus infection.

Abstract:

BACKGROUND:The aim of this study was to evaluate the efficacy of lamivudine (LAM) monoprophylaxis for patients with non-replicating hepatitis B virus (HBV) infection at orthotopic liver transplantation (OLT). METHODS:Among 128 liver recipients with HBV infection between 1994 and 2004 transplanted at our institution, 60 had non-replicating HBV infection at the time of OLT. Of those, 26 patients received LAM prophylaxis (monoprophylaxis group) and 34 patients received LAM and hepatitis B immunoglobulin (HBIG) prophylaxis (combination group) after OLT. RESULTS:Median follow-up after OLT was 67 and 54 months, for monoprophylaxis and combination groups respectively. One and five yr patient/graft survival were 96/85% and 96/80% in monoprophylaxis group, and 85/79% and 67/55% in combination group. HBV DNA was re-detected or increased >10(5) IU/mL in four patients (15%) at 20-29 month in monoprophylaxis group and six (18%) at 4-35 months in combination group. Recurrent hepatitis was seen in two patients (8%) at 27 and 45 months and monoprophylaxis group and three (9%) at 21-35 months in combination group. The rate of recurrence was not statistically different between two groups. CONCLUSION:LAM monoprophylaxis seemed to be effective for OLT recipients with HBV infection who had non-replicating HBV at transplantation. HBIG administration may play a less valuable role in preventing HBV recurrence in this group of patients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Yoshida H,Kato T,Levi DM,Regev A,Madariaga JR,Nishida S,Martinez EJ,Schiff ER,Omata M,Tzakis AG

doi

10.1111/j.1399-0012.2006.00557.x

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

166-71

issue

2

eissn

0902-0063

issn

1399-0012

pii

CTR557

journal_volume

21

pub_type

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