Pancreas after living donor kidney transplants in diabetic patients: impact on long-term kidney graft function.

Abstract:

:In this single-institution study, we compared outcomes in diabetic recipients of living donor (LD) kidney transplants that did vs. did not undergo a subsequent pancreas transplant. Of 307 diabetic recipients who underwent LD kidney transplants from January 1, 1995, through December 31, 2003, a total of 175 underwent a subsequent pancreas after kidney (PAK) transplant; 75 were deemed eligible (E) for, but did not receive (for personal or financial reasons), a PAK, and thus had a kidney transplant alone (KTA); and 57 deemed ineligible (I) for a PAK because of comorbidity also had just a KTA. We analyzed the three groups (PAK, KTA-E, KTA-I) for differences in patient characteristics, glycemic control, renal function, patient and kidney graft survival rates, and causes of death. Kidney graft survival rates (actuarial) were similar in the PAK vs. KTA-E groups at one, five, and 10 yr post-transplant: 98%, 82%, and 67% (PAK) vs. 100%, 84%, and 62% (KTA-E) (p = 0.9). The long-term (greater than four yr post-transplant) estimated glomerular filtration rate (GFR) was higher in the PAK than in the KTA-E group: 53 +/- 20 mL/min (PAK) vs. 43 +/- 16 mL/min (KTA-E) (p = 0.016). The patient survival rates were also similar for the PAK and KTA-E groups. We conclude that the subsequent transplant of a pancreas after an LD kidney transplant does not adversely affect patient or kidney graft survival rates; in fact, it is associated with better long-term kidney graft function.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Kleinclauss F,Fauda M,Sutherland DE,Kleinclauss C,Gruessner RW,Matas AJ,Kasiske BL,Humar A,Kandaswamy R,Kaul S,Gruessner AC

doi

10.1111/j.1399-0012.2009.00998.x

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

437-46

issue

4

eissn

0902-0063

issn

1399-0012

pii

CTR998

journal_volume

23

pub_type

杂志文章
  • Influence of anti-rejection therapy on the timing of cytomegalovirus disease and other infections in renal transplant recipients.

    abstract::Infections are an important cause of mortality and morbidity in renal transplant recipients. To study the impact of anti-rejection therapy on the timing of infections, the records of 599 consecutive renal transplants, performed prior to 31 December 1996 at the Royal Melbourne Hospital, were reviewed. Patients were gro...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140104.x

    authors: Jamil B,Nicholls KM,Becker GJ,Walker RG

    更新日期:2000-02-01 00:00:00

  • Psychosocial barriers associated with organ donation in Mexico.

    abstract:INTRODUCTION:There is a severe shortage of organs for transplantation worldwide, and Mexico has one of the lowest organ donation rates. In this study, we explored the psychosocial barriers that prevent posthumous organ donation by Mexicans. METHOD:We asked 218 adults who were not willing to be donors to complete the s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13112

    authors: Marván ML,Álvarez Del Río A,Jasso K,Santillán-Doherty P

    更新日期:2017-11-01 00:00:00

  • Response to antiviral therapy in liver transplant recipients with recurrent hepatitis C viral infection: a single center experience.

    abstract:INTRODUCTION:Recurrence of hepatitis C virus (HCV) in hepatic allograft is a major concern after successful liver transplant (LTx). AIM:To examine the response rate to pegylated interferon (PEG-IFN) and ribavirin in post-LTx patients with HCV recurrence. PATIENTS AND METHODS:Between January 2003 and September 2006, 6...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.00961.x

    authors: Jain A,Sharma R,Ryan C,Safadjou S,Kashyap R,Mantry P,Maliakkal B,Orloff M

    更新日期:2010-01-01 00:00:00

  • Everolimus leads to a lower risk of BKV viremia than mycophenolic acid in de novo renal transplantation patients: a single-center experience.

    abstract:BACKGROUND:There are limited published data concerning the effects of different immunosuppressive regimens on the development of polyomavirus (BKV) viremia. We examined the risk of developing BKV viremia in kidney transplant recipients receiving everolimus (EVR) or mycophenolic acid (MPA) as maintenance therapy. METHO...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.12151

    authors: Moscarelli L,Caroti L,Antognoli G,Zanazzi M,Di Maria L,Carta P,Minetti E

    更新日期:2013-07-01 00:00:00

  • Transplantation of a severely lacerated liver--a case report with review of the literature.

    abstract::Using lacerated livers for liver transplantation (LTx) can add an option to the extended donor criteria. We present an LTx case using a severely lacerated liver and review of the literature for reported cases. We used a high-grade lacerated liver from a 19-yr-old brain-dead patient caused by traffic accident. The live...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2008.00914.x

    authors: Mehrabi A,Fonouni H,Ahmadi R,Schmied BM,Müller SA,Welsch T,Hallscheidt P,Zeier M,Weitz J,Schmidt J

    更新日期:2009-06-01 00:00:00

  • Pediatric transplantation in Europe during the COVID-19 pandemic: Early impact on activity and healthcare.

    abstract::The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.14063

    authors: Doná D,Torres Canizales J,Benetti E,Cananzi M,De Corti F,Calore E,Hierro L,Ramos Boluda E,Melgosa Hijosa M,Garcia Guereta L,Pérez Martínez A,Barrios M,Costa Reis P,Teixeira A,Lopes MF,Kaliciński P,Branchereau S,Boyer O

    更新日期:2020-10-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00

  • Impact of the new fast track kidney allocation scheme for declined kidneys in the United Kingdom.

    abstract:INTRODUCTION:A "new" fast track kidney allocation scheme (FTKAS) was implemented in the UK in 2012 for offering of previously declined kidneys. We evaluated the impact of the FTKAS in utilization of declined kidneys and outcome. METHODS:Adult renal transplant centers were surveyed. Overall utilization was evaluated us...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12576

    authors: White AD,Roberts H,Ecuyer C,Brady K,Pathak S,Clark B,Hostert LH,Attia MS,Wellberry-Smith M,Hudson A,Ahmad N

    更新日期:2015-10-01 00:00:00

  • To induce or not to induce: a 21st century evaluation of lung transplant immunosuppression's effect on survival.

    abstract:INTRODUCTION:The impact of induction immunosuppression on long-term survival in lung transplant recipients remains unclear. We sought to evaluate the effect of contemporary induction immunosuppression agents in lung transplant recipients' survival, utilizing national registry data. METHODS:We queried the United Networ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12339

    authors: Whitson BA,Lehman A,Wehr A,Hayes D Jr,Kirkby S,Pope-Harman A,Kilic A,Higgins RS

    更新日期:2014-04-01 00:00:00

  • Humoral immunity in renal transplantation: epitopes, Cw and DP, and complement-activating capability--an update.

    abstract::Humoral immune responses can destroy a renal allograft. In January 2013, Consensus Guidelines were published regarding testing and management concerns with respect to antibodies in transplantation. New studies have been reported over the past two yr and controversies remain. We review here the new data in light of the...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12524

    authors: Filippone EJ,Farber JL

    更新日期:2015-04-01 00:00:00

  • Indications and outcomes of pancreatic surgery after liver transplantation.

    abstract:BACKGROUND:Prior liver transplantation and immunosuppression potentially translate into significant morbidity and poor outcomes after any type of pancreatic surgery. Little is known about the outcomes of pancreatic surgery after liver transplantation. This study was designed to review our experience regarding the indic...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12317

    authors: Mejia J,Sucandy I,Steel J,Golas B,Humar A,Lee K,Zeh H,Marsh J,Tsung A

    更新日期:2014-03-01 00:00:00

  • Liver transplant center risk tolerance.

    abstract::Recent changes in Center for Medicare & Medicaid Services (CMS) condition for participation, using benchmark volume/outcomes requirements for certification, have been implemented. Consequently, the ability of a transplant center to assess its risk tolerance is important in successful management. An analysis of SRTR da...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01658.x

    authors: Johnson SR,Karp SJ,Curry MP,Barugel M,Rodrigue JR,Mandelbrot DA,Rogers CP,Hanto DW

    更新日期:2012-05-01 00:00:00

  • Tuberculosis in southern Chinese renal-transplant recipients.

    abstract:OBJECTIVES:To analyze the characteristics of tuberculosis (TB) in Southern Chinese renal transplant recipients, and summarize the corresponding experiences in diagnosis and management. METHOD:Retrospectively study 41 documented post-transplant TB cases out of the 2333 patients who received kidney transplantation in th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00878.x

    authors: Chen SY,Wang CX,Chen LZ,Fei JG,Deng SX,Qiu J,Li J,Chen GO,Fu HM,Xie CM

    更新日期:2008-11-01 00:00:00

  • Serum globulin levels in predicting the extent of hepatic fibrosis in patients with recurrent post-transplant hepatitis C infection.

    abstract::The progression of HCV-related disease is particularly aggressive in the post-transplantation setting. Recipients with recurrent HCV infection undergo repeated liver biopsies in order to estimate disease progression. A strong association was found between serum immunoglobulins levels and hepatic fibrosis in non-transp...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00657.x

    authors: Schmilovitz-Weiss H,Cohen M,Pappo O,Sulkes J,Braun M,Tur-Kaspa R,Ben-Ari Z

    更新日期:2007-05-01 00:00:00

  • Risk of early, intermediate, and late rejection following heart transplantation: Trends over the past 25 years and relation to changes in medical management. Tertiary center experience: The Sheba Heart Transplantation Registry.

    abstract:AIM:To explore the trends in the risk for rejection following heart transplantation (HT) over the past 25 years, and their relation to changes in medical management. METHODS:The study population comprised 216 HT patients. Rejection periods were defined as follows: 0-3 months (early), 3-12 months (intermediate), and 12...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13063

    authors: Katz M,Freimark D,Raichlin E,Har-Zahav Y,Arad M,Kassif Y,Peled A,Asher E,Elian D,Kogan A,Shlomo N,Ofek E,Lavee J,Goldenberg I,Peled Y

    更新日期:2017-10-01 00:00:00

  • Functional assessment of immune markers of graft rejection: a comprehensive study in live-related donor renal transplantation.

    abstract::A better understanding of the immunobiological processes and predictors of graft rejection holds promise for the development of potential therapeutic strategies and also individualization of immunosuppression. The objective of this study is to analyze the clinical relevance of immune parameters such as antidonor antih...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00445.x

    authors: Panigrahi A,Deka R,Bhowmik D,Dash SC,Tiwari SC,Guleria S,Mehta SN,Mehra NK

    更新日期:2006-01-01 00:00:00

  • The impact of obesity in renal transplantation: an analysis of paired cadaver kidneys.

    abstract:BACKGROUND:Previous studies indicate that obesity is a risk factor in renal transplantation. However, these analyses did not control for variable donor factors that may strongly influence outcome. To control for donor variables such as age, cause of death, procurement techniques, preservation methods, cold ischaemia ti...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.01080.x

    authors: Yamamoto S,Hanley E,Hahn AB,Isenberg A,Singh TP,Cohen D,Conti DJ

    更新日期:2002-08-01 00:00:00

  • The impact of pancreas transplantation on patient employment opportunities.

    abstract:BACKGROUND:A questionnaire study was designed to determine whether the quality of life benefit provided by receiving a kidney-pancreas (KP) transplant increased the incentive to return to work, compared with patients receiving a kidney alone (KA) transplant. METHODS:A confidential questionnaire was sent to 58 patients...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00115.x

    authors: Knight RJ,Daly L

    更新日期:2004-02-01 00:00:00

  • Prognostication of inflammatory cells in liver transplantation: Is the waitlist neutrophil-to-lymphocyte ratio really predictive of tumor biology?

    abstract:OBJECTIVE:The objective of this retrospective study was to characterize the neutrophil to lymphocyte ratio (NLR) on the waitlist and determine its prognostic utility in liver transplantation (LT) for hepatocellular carcinoma (HCC) with special focus on longitudinal data. Biomarkers such as pre-operative NLR have been s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13743

    authors: McVey JC,Sasaki K,Firl DJ,Fujiki M,Diago-Uso T,Quintini C,Eghtesad B,Miller CC,Hashimoto K,Aucejo FN

    更新日期:2019-12-01 00:00:00

  • Living donors' experiences 1 wk after donating a kidney.

    abstract::In Norway living kidney donors account for approximately 40% of all renal transplants. There is a shortage of information about how living kidney donors experience the donation process during the initial recovery from surgery. The aim of this study was to explore physical and psychosocial issues related to the experie...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00304.x

    authors: Andersen MH,Mathisen L,Øyen O,Wahl AK,Hanestad BR,Fosse E

    更新日期:2005-02-01 00:00:00

  • Bone mineral density and osteoporosis in heart transplanted patients: A single-center retrospective study at Skåne University Hospital in Lund 1988-2016.

    abstract::Bone mineral density (BMD) in the lumbar spine and femoral neck, the incidence of osteoporosis, and survival up to 10 years after heart transplantation (HT) were investigated in 169 patients who underwent HT at Skåne University Hospital in Lund, Sweden, 1988-2016. Within the first year post-transplantation, mean (SD) ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13477

    authors: Löfdahl E,Söderlund C,Rådegran G

    更新日期:2019-03-01 00:00:00

  • A new approach to kidney wait-list management in the kidney allocation system era: Pilot implementation and evaluation.

    abstract::Kidney transplant wait-list management is becoming increasingly complex. We introduced a novel wait-list management strategy at our center, the Transplant Readiness Assessment Clinic (TRAC), whereby patients whose Kidney Allocation Scores surpass a threshold are actively managed. From January 1, 2016 through June 30, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13406

    authors: Cheng XS,Busque S,Lee J,Discipulo K,Hartley C,Tulu Z,Scandling JD,Tan JC

    更新日期:2018-11-01 00:00:00

  • Plasma mycophenolic acid concentration and the clinical outcome after lung transplantation.

    abstract:BACKGROUND:The therapeutic drug monitoring of mycophenolic acid (MPA) has been investigated for renal and heart transplantations; however, its usefulness in lung transplantation is unclear. METHODS:The MPA area under the plasma concentration-time curve (AUC) was calculated in 59 adult lung transplant recipients. The M...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14088

    authors: Yabuki H,Matsuda Y,Watanabe T,Eba S,Hoshi F,Hirama T,Oishi H,Sado T,Noda M,Sakurada A,Kikuchi M,Yamaguchi H,Mano N,Okada Y

    更新日期:2020-12-01 00:00:00

  • Methamphetamine use in deceased kidney donors impairs one-yr graft function.

    abstract:BACKGROUND:Methamphetamine (MA) has cumulative deleterious effects on multiple organ systems. A history of MA exposure in kidney donors may affect adversely graft function in recipients. METHODS:Between September 2000 and March 2004, all deceased kidney donors were identified from the local registry (97 donors). Twent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00703.x

    authors: Inouye DS,Kickertz K,Wong LL

    更新日期:2007-09-01 00:00:00

  • The influence of CTLA-4 single nucleotide polymorphisms on acute kidney allograft rejection in Turkish patients.

    abstract::Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a cell surface protein, which down-regulates the immune response at CTLA-4/CD28/B7 pathway. We aimed to investigate the influence of the -318 C/T, +49 A/G, -1661 A/G and CT60A/G, and CTLA-4 gene polymorphisms on acute rejection of kidney allograft in Turkish patients. The s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ctr.12563

    authors: Ruhi Ç,Sallakçi N,Yeğin O,Süleymanlar G,Ersoy FF

    更新日期:2015-07-01 00:00:00

  • Steroid-related complications in the cyclosporine era.

    abstract::Steroid withdrawal has potential risks (rejection) and benefits (fewer complications). Most data on steroid-related complications predates cyclosporine (CsA). We tabulated the incidence of posttransplant complications considered to be steroid-related in 748 adult kidney transplant recipients (with at least 1 year of f...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Fryer JP,Granger DK,Leventhal JR,Gillingham K,Najarian JS,Matas AJ

    更新日期:1994-06-01 00:00:00

  • A comparison of daclizumab to ATGAM induction in simultaneous pancreas-kidney transplant recipients on triple maintenance immunosuppression.

    abstract::Daclizumab (DAC) is a molecularly engineered humanized IgGa monoclonal Ab directed against the alpha chain of the interleukin-2 receptor (IL2R). Inhibiting the amplification of the immune response by blocking IL2R can reduce the frequency of acute rejection without the attendant risk of infection. The purpose of this ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.14040902.x

    authors: Rasaiah SB,Light JA,Sasaki TM,Currier CB

    更新日期:2000-08-01 00:00:00

  • Attenuated early inflammatory response in solid organ recipients with COVID-19.

    abstract::Immunosuppression leaves transplanted patients at particular risk for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. The specific features of coronavirus disease 2019 (COVID-19) in immunosuppressed patients are largely unknown and therapeutic experience is lacking. Seven transplanted patients (two liver, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14027

    authors: Bösch F,Börner N,Kemmner S,Lampert C,Jacob S,Koliogiannis D,Stangl M,Michel S,Kneidinger N,Schneider C,Fischereder M,Irlbeck M,Denk G,Werner J,Angele MK,Guba MO

    更新日期:2020-10-01 00:00:00

  • The impact of bacterial colonization on graft success after total pancreatectomy with autologous islet transplantation: considerations for early definitive surgical intervention.

    abstract:OBJECTIVE:The purpose of this study was to determine whether bacterial contamination of islets affects graft success after total pancreatectomy with islet autotransplantation (TPIAT). BACKGROUND:Factors associated with insulin independence after TPIAT are inconclusive. Although bacterial contamination does not preclud...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12842

    authors: Jolissaint JS,Langman LW,DeBolt CL,Tatum JA,Martin AN,Wang AY,Strand DS,Zaydfudim VM,Adams RB,Brayman KL

    更新日期:2016-11-01 00:00:00

  • LabMELD-based organ allocation increases total costs of liver transplantation: a single-center experience.

    abstract:INTRODUCTION:In 2006, model for end-stage liver disease (MELD)-based allocation was implemented in the Eurotransplant (ET) region. Sick patients, who in general require more resources, are prioritized. In this analysis, the effect of MELD on costs for liver transplantation (LTx) was assessed. METHODS:Total costs for L...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2011.01483.x

    authors: Bruns H,Hillebrand N,Schneider T,Hinz U,Fischer L,Schmidt J,Goldschmidt AJ,Schemmer P

    更新日期:2011-09-01 00:00:00