当前位置： SCI文献检索 > CLINICAL TRANSPLANTATION期刊下所有文献 > Plasma mycophenolic acid concentration and the clinical outcome after lung transplantation.

Plasma mycophenolic acid concentration and the clinical outcome after lung transplantation.

Abstract：

BACKGROUND:The therapeutic drug monitoring of mycophenolic acid (MPA) has been investigated for renal and heart transplantations; however, its usefulness in lung transplantation is unclear. METHODS:The MPA area under the plasma concentration-time curve (AUC) was calculated in 59 adult lung transplant recipients. The MPA AUC0-12 s were compared among the three groups determined by the presence of adverse events (no events, infection, and chronic lung allograft dysfunction [CLAD]). Next, MPA AUC0-12 thresholds for the adverse events were identified by receiver operating characteristic analysis. Cumulative occurrence rate of the adverse events was compared between two groups (adequate and inadequate groups) according to the thresholds. RESULTS:The MPA AUC0-12 s in the no event, infection, and CLAD groups were 30.3 ± 6.5, 36.8 ± 10.7, and 20.6 ± 9.6 µg·h/mL, respectively (P = .0027), while the tacrolimus trough levels were similarly controlled in the groups. The thresholds of MPA AUC0-12 for the occurrence of infection and CLAD were 40.5 and 22.8 µg·h/mL, respectively. The cumulative occurrence rate of adverse events of adequate group (15.3%) was significantly lower than that of inadequate group (56.0%) (P = .0050). CONCLUSIONS:The MPA AUC0-12 may affect the occurrence of adverse events in lung transplant recipients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Yabuki H,Matsuda Y,Watanabe T,Eba S,Hoshi F,Hirama T,Oishi H,Sado T,Noda M,Sakurada A,Kikuchi M,Yamaguchi H,Mano N,Okada Y

doi

10.1111/ctr.14088

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

e14088

issue

12

eissn

0902-0063

issn

1399-0012

journal_volume

34

pub_type

杂志文章

相关文献

CLINICAL TRANSPLANTATION文献大全
  • Immunization by blood-type antigen in human immunoglobulin products before ABO-incompatible kidney transplantation.

    abstract：:A 29-year-old man wanted to receive an ABO-incompatible kidney transplant. His blood type was O, and the donor, his father, was A1. After endoscopic splenectomy performed before kidney transplantation, the recipient developed a high fever and leukocytosis, and he was treated with antibiotics and 5 g of human immunoglo...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1046/j.1399-0012.2003.00144.x

    authors： Sawada T,Ando T,Sato S,Kubota K,Fuchinoue S,Teraoka S

    更新日期：2004-04-01 00:00:00

  • Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension.

    abstract：:In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of po...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/ctr.13360

    authors： Issa N,Sánchez OA,Kukla A,Riad SM,Berglund DM,Ibrahim HN,Matas AJ

    更新日期：2018-09-01 00:00:00

  • The pathogenesis of xenograft rejection.

    abstract：:The transplantation of vascularized organs between species stimulates an intense rejection reaction by the recipient of the graft. The classification of the xenograft rejection reaction on the basis of the degree of genetic disparity between donor and recipient species and the presence or absence of preformed antibody...

    journal_title：Clinical transplantation

    pub_type： 杂志文章,评审

    doi：

    authors： Makowka L,Cramer DV

    更新日期：1994-04-01 00:00:00

  • Open or laparoscopic mesh repair of incisional hernia in patients that underwent liver transplantation: A systematic review and proportional meta-analysis.

    abstract：BACKGROUND:Incisional hernias, that significantly affect the quality of life of patients, are common complications especially after major surgery, such as liver transplantation. The purpose of this meta-analysis is to outline the available evidence on the complications occurring after mesh implantation as a treatment o...

    journal_title：Clinical transplantation

    pub_type： 杂志文章,评审

    doi：10.1111/ctr.14103

    authors： Frountzas M,Nikolaou C,Maris S,Stavrou E,Giannopoulos P,Schizas D,Stergios K,Toutouzas K

    更新日期：2020-12-01 00:00:00

  • Anti-IL-2R blockers comparing with polyclonal antibodies: Higher risk of rejection without negative mid-term outcomes after ABO-incompatible kidney transplantation.

    abstract：:There is no recommendation regarding the type of induction therapy to use in ABO-incompatible (ABOi) kidney transplantation. The aim of this retrospective study was to compare the outcome of ABOi living donor kidney transplant (LDKT) recipients who received either polyclonal antibodies or anti-interleukin-2 receptor (...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/ctr.13681

    authors： Del Bello A,Divard G,Belliere J,Congy-Jolivet N,Lanfranco L,Ricard R,Delas A,Colombat M,Esposito L,Hebral AL,Cointault O,Lefaucheur C,Loupy A,Kamar N

    更新日期：2019-10-01 00:00:00

  • Pseudoaneurysm of the superior mesenteric artery with an arteriovenous fistula after simultaneous kidney-pancreas transplantation.

    abstract：:Vascular complications remain a significant source of morbidity after pancreatic transplantation. We describe a pseudoaneurysm of the superior mesenteric artery (SMA) with an arteriovenous fistula (AVF) involving the SMA and the superior mesenteric vein (SMV) discovered and treated surgically in the second week after ...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1034/j.1399-0012.1999.130310.x

    authors： Khan TF,Ciancio G,Burke GW 3rd,Sfakianakis GN,Miller J

    更新日期：1999-06-01 00:00:00

  • Successful pancreas transplantation alone is associated with excellent self-identified health score and glucose control: A retrospective study from a high-volume center in the United States.

    abstract：BACKGROUND:The benefits of pancreas transplantation are often difficult to measure. Here, we sought to determine the difference in quality of life for diabetic patients with and without a functional pancreas transplant alone (PTA). METHODS:Pancreas transplant alone cases from 1993 to 2015 were considered. An IRB-appro...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/ctr.13177

    authors： Scalea JR,Pettinato L,Fiscella B,Bartosic A,Piedmonte A,Paran J,Todi N,Siskind EJ,Bartlett ST

    更新日期：2018-02-01 00:00:00

  • Factors related to attitudes toward organ donation after death in the immigrant population in Spain.

    abstract：:Considering the relevance of the migratory processes in Western societies, the attitudes toward organ donation after death are analyzed by means of a survey applied to a representative random sample of the resident immigrant population in Spain, comprising 1202 subjects (estimated margin of error of ± 2.88%, p = q, p ...

    journal_title：Clinical transplantation

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1399-0012.2011.01586.x

    authors： López JS,Valentín MO,Scandroglio B,Coll E,Martín MJ,Sagredo E,Martínez JM,Serna E,Matesanz R

    更新日期：2012-05-01 00:00:00

  • Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral.

    abstract：:Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion deliv...

    journal_title：Clinical transplantation

    pub_type： 杂志文章,评审

    doi：

    authors： Ritschel WA

    更新日期：1996-08-01 00:00:00

  • Multiple renal arteries do not pose an impediment to the routine use of laparoscopic donor nephrectomy.

    abstract：UNLABELLED:Since the first description by Ratner and collegues in 1996, laparoscopic live-donor nephrectomy is gaining wide acceptance in an attempt to minimize the donor morbidity, length of hospital stay and length of time to return to work. It is unknown whether multiple renal arteries pose additional problems with ...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1034/j.1399-0012.2001.00012.x

    authors： Johnston T,Reddy K,Mastrangelo M,Lucas B,Ranjan D

    更新日期：2001-01-01 00:00:00

  • Attenuated early inflammatory response in solid organ recipients with COVID-19.

    abstract：:Immunosuppression leaves transplanted patients at particular risk for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. The specific features of coronavirus disease 2019 (COVID-19) in immunosuppressed patients are largely unknown and therapeutic experience is lacking. Seven transplanted patients (two liver, ...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/ctr.14027

    authors： Bösch F,Börner N,Kemmner S,Lampert C,Jacob S,Koliogiannis D,Stangl M,Michel S,Kneidinger N,Schneider C,Fischereder M,Irlbeck M,Denk G,Werner J,Angele MK,Guba MO

    更新日期：2020-10-01 00:00:00

  • Elevated calcium phosphate product after renal transplantation is a risk factor for graft failure.

    abstract：BACKGROUND:Abnormal mineral metabolism is not uncommon after renal transplant (TXP). In dialysis patients, elevated serum phosphorous (P), calcium (Ca), CaP product, and parathyroid hormone (PTH) are associated with increased morbidity and mortality. The effect of these abnormalities on recipient and graft survival aft...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2007.00690.x

    authors： Egbuna OI,Taylor JG,Bushinsky DA,Zand MS

    更新日期：2007-07-01 00:00:00

  • Flow cytometry crossmatching and primary cadaver kidney graft outcome: relevance of T and B cell targets, historic sera and autologous controls.

    abstract：:There is limited information regarding the role of flow cytometry crossmatching (FCXM) in primary cadaver kidney allografting and even less about B cell reactivity and graft survival (GS). Furthermore, there is little or no published data concerning reaction strength (cutoff value), the effect of historic sera reactio...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：

    authors： LeFor WM,Ackermann JR,Alveranga DY,Bowers VD,Heinrichs DF,Kahana L,Shires DL Jr,Weinstein SS,Wright CE

    更新日期：1996-12-01 00:00:00

  • Echinocandin use in lung transplant recipients.

    abstract：BACKGROUND:Invasive fungal infections (IFI) are associated with significant morbidity and mortality in lung transplant recipients (LTRs). However, data outlining use of echinocandins in prophylaxis and therapy of LTRs are limited. METHOD:A single-center retrospective cohort study on all LTRs from January-2010 to Decem...

    journal_title：Clinical transplantation

    pub_type： 临床试验,杂志文章

    doi：10.1111/ctr.13437

    authors： Al Jishi Y,Rotstein C,Kumar D,Humar A,Singer LG,Keshavjee S,Husain S

    更新日期：2018-12-01 00:00:00

  • Multicultural issues in organ transplantation: the influence of patients' cultural perspectives on compliance with treatment.

    abstract：:The potential influence of racially or ethnically diverse cultural perspectives on patient compliance with post-transplant treatments is discussed. Domains of competency regarding culturally sensitive clinical practice are outlined to assist providers in better understanding the perspectives that may influence the vie...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：

    authors： Prieto LR,Miller DS,Gayowski T,Marino IR

    更新日期：1997-12-01 00:00:00

  • The curative treatment of familial hypercholesterolemia: Liver transplantation.

    abstract：BACKGROUND:Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder characterized by premature mortal cardiovascular complications. Liver transplantation (LT) is the only curative treatment option. In this study, the long-term clinical follow-up data of 8 patients who underwent LT with a diagnosis o...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/ctr.13730

    authors： Gulsoy Kirnap N,Kirnap M,Bascil Tutuncu N,Moray G,Haberal M

    更新日期：2019-12-01 00:00:00

  • Serum globulin levels in predicting the extent of hepatic fibrosis in patients with recurrent post-transplant hepatitis C infection.

    abstract：:The progression of HCV-related disease is particularly aggressive in the post-transplantation setting. Recipients with recurrent HCV infection undergo repeated liver biopsies in order to estimate disease progression. A strong association was found between serum immunoglobulins levels and hepatic fibrosis in non-transp...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2007.00657.x

    authors： Schmilovitz-Weiss H,Cohen M,Pappo O,Sulkes J,Braun M,Tur-Kaspa R,Ben-Ari Z

    更新日期：2007-05-01 00:00:00

  • Efficacy and safety of enteric-coated mycophenolate sodium in renal transplant patients with diabetes mellitus: post hoc analyses from three clinical trials.

    abstract：:To examine the efficacy and safety of enteric-coated mycophenolate sodium (EC-MPS, myfortic) in renal transplant patients with diabetes mellitus, six- and 12-month data from three clinical trials with EC-MPS (Studies B301, B302, and myPROMS) were analyzed post hoc. Studies B301 (de novo patients) and B302 (maintenance...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2006.00615.x

    authors： Pietruck F,Budde K,Salvadori M,Sollinger H,Bourbigot B,Gentil MA,Oppenheimer F

    更新日期：2007-01-01 00:00:00

  • Lung transplantation for patients with end-stage Sauropus androgynus-induced bronchiolitis obliterans (SABO) syndrome.

    abstract：:Sauropus androgymus (SA), a vegetable of the Euphorbiaceae family, is a common food source in Malaysia. In Taiwan, over 30 patients have developed progressive respiratory failure after consuming the extract from raw SA leaves as a means of losing weight. Symptoms consistent with a severe obstructive ventilatory defect...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1034/j.1399-0012.1999.130610.x

    authors： Luh SP,Lee YC,Chang YL,Wu HD,Kuo SH,Chu SH

    更新日期：1999-12-01 00:00:00

  • Long-term outcomes of dual kidney transplantation-a single center experience.

    abstract：:The shortage of kidney donors has led to broadening of the acceptance criteria for deceased donor organs beyond the traditional use of young donors. We determined long-term post-transplant outcomes in recipients of dual expanded criteria donor kidneys (dECD, n = 44) and compared them to recipients of standard criteria...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2009.00956.x

    authors： Salifu MO,Norin AJ,O'Mahony C,Sumrani N,Apel A,Ikram M,Alam A,Hayat A,Jindal RM,Friedman EA,Distant DA

    更新日期：2009-06-01 00:00:00

  • Steroid withdrawal in pancreas transplant recipients.

    abstract：BACKGROUND:Numerous studies of steroid withdrawal have been carried out in kidney and liver transplant recipients, but only a few in pancreas transplant recipients. Yet, pancreas transplant recipients could have significant long-term benefits from steroid withdrawal. METHODS:We performed a retrospective analysis to de...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1034/j.1399-0012.2000.140114.x

    authors： Humar A,Parr E,Drangstveit MB,Kandaswamy R,Gruessner AC,Sutherland DE

    更新日期：2000-02-01 00:00:00

  • High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.

    abstract：:The non-relapse mortality of autologous stem cell transplant is low enough that the procedure has been extended to older patients with non-Hodgkin's lymphoma. We treated 537 non-Hodgkin's lymphoma patients with high-dose chemotherapy consisting of busulfan, cyclophosphamide, and etoposide followed by autologous stem c...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2006.00581.x

    authors： Kalaycio M,Pohlman B,Kuczkowski E,Rybicki L,Andresen S,Sobecks R,Bolwell B

    更新日期：2006-11-01 00:00:00

  • Multidetector CT angiography in living donor renal transplantation: accuracy and discrepancies in right venous anatomy.

    abstract：:Multidetector computed tomography (MDCT) angiography is a reliable technique for assessing pre-operative renal anatomy in living kidney donors. The method has largely evolved into protocols that eliminate dedicated venous phase and instead utilize a combined arterial/venous phase to delineate arterial and venous anato...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2009.01193.x

    authors： Kulkarni S,Emre S,Arvelakis A,Asch W,Bia M,Formica R,Israel G

    更新日期：2011-01-01 00:00:00

  • Regional differences in deceased donor liver transplantation and their implications for organ utilization and allocation.

    abstract：:We examined the UNOS database from 7/15/00-7/17/05 for Regional deceased donor liver utilization. For each region, we performed logistic regression and derived odds ratios (OR) for donor characteristics associated with livers being transplanted outside of the region or not transplanted at all. Regions with smallest an...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2010.01214.x

    authors： Hayashi PH,Axelrod DA,Galanko J,Salvalaggio PR,Schnitzler M

    更新日期：2011-01-01 00:00:00

  • Serial perfusion in native lungs in patients with idiopathic pulmonary fibrosis and other interstitial lung diseases after single lung transplantation.

    abstract：BACKGROUND:Lung perfusions after single lung transplantation (SLT) have not been fully clarified in patients with interstitial lung disease (ILD). The present study aimed to investigate temporal changes in native lung perfusion and their associated clinical factors in patients with ILD who have undergone SLT. METHODS:...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/ctr.12701

    authors： Sokai A,Handa T,Chen F,Tanizawa K,Aoyama A,Kubo T,Ikezoe K,Nakatsuka Y,Oguma T,Hirai T,Nagai S,Chin K,Date H,Mishima M

    更新日期：2016-04-01 00:00:00

  • Religious beliefs and opinions on clinical xenotransplantation--a survey of university students from Kenya, Sweden and Texas.

    abstract：:This study investigated the association between religious beliefs and opinions on xenotransplantation among students from three different countries. A lower proportion of religious students accepted xenotransplantation than did non-religious students. A higher proportion of Protestant students seemed to accept xenotra...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1034/j.1399-0012.2001.150610.x

    authors： Hagelin J,Hau J,Schapiro SJ,Suleman MA,Carlsson HE

    更新日期：2001-12-01 00:00:00

  • Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    abstract：:These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice provide recommendations for the diagnosis and management of Candida infections in solid organ transplant recipients. Candida infections manifest primarily as candidemia and invasive candidiasis and cause con...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/ctr.13623

    authors： Aslam S,Rotstein C,AST Infectious Disease Community of Practice.

    更新日期：2019-09-01 00:00:00

  • Impact of venous drainage on regeneration of the anterior segment of right living-related liver grafts.

    abstract：:The effect of additional venous reconstruction on morphologic and functional regeneration of the anterior segment of right-lobe liver grafts was compared among three groups according to graft type: right liver graft without the middle hepatic vein (MHV) or MHV tributaries (n=7), with MHV tributaries (n=25) and with th...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1111/j.1399-0012.2006.00515.x

    authors： Mizuno S,Iida T,Yagi S,Usui M,Sakurai H,Isaji S,Uemoto S

    更新日期：2006-07-01 00:00:00

  • Reduced dose Thymoglobulin, tacrolimus, and mofetil mycophenolate results in excellent solitary pancreas transplantation outcomes.

    abstract：BACKGROUND:Graft survival following solitary pancreas transplantation has traditionally lagged behind that of simultaneous pancreas-kidney transplants. Thymoglobulin (TMG), a polyclonal rabbit-derived antilymphocyte antibody was originally introduced as treatment for acute rejection of renal allografts. However, data r...

    journal_title：Clinical transplantation

    pub_type： 杂志文章

    doi：10.1034/j.1399-0012.2002.02031.x

    authors： Tan M,Cantarovich M,Mangel R,Paraskevas S,Fortier M,Metrakos P

    更新日期：2002-12-01 00:00:00

  • Transplantation of a severely lacerated liver--a case report with review of the literature.

    abstract：:Using lacerated livers for liver transplantation (LTx) can add an option to the extended donor criteria. We present an LTx case using a severely lacerated liver and review of the literature for reported cases. We used a high-grade lacerated liver from a 19-yr-old brain-dead patient caused by traffic accident. The live...

    journal_title：Clinical transplantation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1399-0012.2008.00914.x

    authors： Mehrabi A,Fonouni H,Ahmadi R,Schmied BM,Müller SA,Welsch T,Hallscheidt P,Zeier M,Weitz J,Schmidt J

    更新日期：2009-06-01 00:00:00