Anti-IL-2R blockers comparing with polyclonal antibodies: Higher risk of rejection without negative mid-term outcomes after ABO-incompatible kidney transplantation.

Abstract:

:There is no recommendation regarding the type of induction therapy to use in ABO-incompatible (ABOi) kidney transplantation. The aim of this retrospective study was to compare the outcome of ABOi living donor kidney transplant (LDKT) recipients who received either polyclonal antibodies or anti-interleukin-2 receptor (IL-2R) blockers as an induction agent. All ABOi HLA-compatible patients that received a LDKT between 03/11 and 03/18 in three French transplantation center (Paris Saint-Louis, Paris Necker, and Toulouse) were included in the study. Fifty-eight patients were given polyclonal antibodies and 39 patients received anti-IL-2R blockers. We identified by a Cox proportional hazard model the use of polyclonal antibodies as a protective factor against acute rejection (HR = 0.4, 95%CI [0-0.9], P < .05). However, pathological findings on protocol biopsies at 1 year were similar in both groups, as were patient and graft survivals, renal function, and complications. We conclude that the acute rejection rate was significantly higher in patients given anti-IL-2R blockers compared to polyclonal antibodies. However, in our series, there was no negative impact on mid-term outcome.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Del Bello A,Divard G,Belliere J,Congy-Jolivet N,Lanfranco L,Ricard R,Delas A,Colombat M,Esposito L,Hebral AL,Cointault O,Lefaucheur C,Loupy A,Kamar N

doi

10.1111/ctr.13681

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

e13681

issue

10

eissn

0902-0063

issn

1399-0012

journal_volume

33

pub_type

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