High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.

Abstract:

:The non-relapse mortality of autologous stem cell transplant is low enough that the procedure has been extended to older patients with non-Hodgkin's lymphoma. We treated 537 non-Hodgkin's lymphoma patients with high-dose chemotherapy consisting of busulfan, cyclophosphamide, and etoposide followed by autologous stem cell transplant. Sixteen patients were identified who died of pulmonary complications at a five-year incidence of 3.6%. Risk factors for pulmonary mortality included older age and lower baseline D(CO) and FEV1. We conclude that high-dose busulfan is associated with pulmonary mortality after autologous transplant, particularly in older patients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Kalaycio M,Pohlman B,Kuczkowski E,Rybicki L,Andresen S,Sobecks R,Bolwell B

doi

10.1111/j.1399-0012.2006.00581.x

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

783-7

issue

6

eissn

0902-0063

issn

1399-0012

pii

CTR581

journal_volume

20

pub_type

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    doi:

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    doi:

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    journal_title:Clinical transplantation

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    doi:

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    doi:

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    doi:

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