Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension.

Abstract:

:In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of postdonation weight gain trends and any associated risks. We tracked serial BMIs in 940 donors for a median (IQ range) follow-up of 22.3 (15.4-35.8) years. We studied the impact of postdonation weight gain in a model adjusted for family history of HTN or DM. Donor characteristics included age, sex, smoking, fasting blood glucose, eGFR, systolic and diastolic BP, and BMI at time of donation and time postdonation. Postdonation weight gain was associated with a significant increase in the relative risk of developing HTN RR 1.93 (95% CI 1.51-2.46) (P < 0.001) and/or DM RR 4.18 (95% CI 2.05-8.5) (P < 0.0001), but not (to date) cardiovascular disease (CVD), reduced eGFR or death. Like the general population, donors gained weight as they aged; a higher BMI was associated with higher incidence of DM and HTN. Postdonation care should include ongoing counseling on the risks of substantial weight gain.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Issa N,Sánchez OA,Kukla A,Riad SM,Berglund DM,Ibrahim HN,Matas AJ

doi

10.1111/ctr.13360

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

e13360

issue

9

eissn

0902-0063

issn

1399-0012

journal_volume

32

pub_type

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