SDF-1 expression is elevated in chronic human renal allograft rejection.

Abstract:

:The exact mechanism of acute and chronic allograft rejection still remains unclear. The chemokine SDF-1 as mediator of allograft rejection has been under intensive investigation in liver, cardiac and bone marrow transplantation, whereas in renal transplantation, there are no reports about SDF-1 to date. This study was performed to evaluate if SDF-1 might also play an important role in human renal graft biopsies. One hundred and ninety formalin-fixed, paraffin-embedded renal allograft biopsies were included in the analysis from patients with normal renal graft morphology (according to Banff 97 classification grade 1, n = 84), with acute interstitial rejection (Banff grade 4 type I, n = 10), with acute vascular rejection (Banff grade 4 type II, n = 21), with chronic allograft nephropathy (CAN, Banff grade 5, n = 23), and without rejection but with various other lesions (Banff grade 6, n = 42). SDF-1 was localized by immunohistochemistry. In biopsies with CAN, SDF-1 expression was significantly elevated in interstitial infiltrates and infiltrating neointimal cells of arteries compared with biopsies with normal renal graft morphology. This is the first study describing a role of SDF-1 in human renal allograft rejection. We were able to demonstrate in a large number of biopsies an upregulation of SDF-1 in patients with CAN. Whether SDF-1 has pro-inflammatory or protective properties in this setting has to be evaluated in further trials.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Hoffmann U,Banas B,Krüger B,Banas M,Bergler T,Böger C,Kammerl M,Obed A,Rümmele P,Segerer S,Riegger GA,Krämer BK

doi

10.1111/j.1399-0012.2006.00540.x

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

712-8

issue

6

eissn

0902-0063

issn

1399-0012

pii

CTR540

journal_volume

20

pub_type

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