Clinical outcomes of liver transplantation for HBV-related hepatocellular carcinoma: data from the NIH HBV OLT study.

Abstract:

BACKGROUND:Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is an indication for orthotopic liver transplantation (OLT) in patients with tumor stage within the United Network for Organ Sharing criteria. The number of patients listed for HBV-related HCC is increasing, while the number of patients listed for HBV-related cirrhosis is declining presumptively because of the availability of more effective oral nucleos(t)ide analogues. This study presents the final, long-term outcome of patients transplanted for HBV-related HCC in the National Institutes of Health (NIH) HBV OLT Study Group. RESULTS:Ninety-eight patients (52.4%) in the NIH HBV OLT cohort underwent OLT for HBV-related HCC. With a mean follow-up of 36.5 months post-OLT, 12 (12.2%) patients developed recurrence of HCC. Multivariate analysis did not find a statistically significant role of gender, tumor stage at OLT, pre-OLT HCC treatment, recurrence of HBV, or duration of HCC diagnosis pre-OLT in predicting HCC recurrence. Serum alpha-fetoprotein (AFP) level >200 ng/mL at transplant was found to be statistically significant in predicting HCC recurrence (p=0.003). HCC recurrence was significantly associated with decreased post-OLT survival. CONCLUSION:HCC is the most common indication for OLT in patients with chronic hepatitis B in the era of more effective oral antivirals. Serum AFP at the time of OLT is significantly associated with HCC recurrence.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Han SH,Reddy KR,Keeffe EB,Soldevila-Pico C,Gish R,Chung RT,Degertekin B,Lok A,NIH HBV OLT Study Group.

doi

10.1111/j.1399-0012.2010.01349.x

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

E152-62

issue

2

eissn

0902-0063

issn

1399-0012

journal_volume

25

pub_type

杂志文章
  • Outcome of lung transplantation in non-idiopathic pulmonary fibrosis interstitial lung disease.

    abstract::Lung transplantation remains the only curative treatment option for selected patients with end-stage interstitial lung disease (ILD). Candidate selection is impeded by patient heterogeneity, particularly in the subgroup of non-idiopathic pulmonary fibrosis (non-IPF) interstitial lung diseases. We performed a descripti...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13661

    authors: Bode H,Verleden SE,Wuyts WA,Yserbyt J,Verleden GM,Vos R

    更新日期:2019-10-01 00:00:00

  • Aortoiliac surgery concomitant with kidney transplantation: a single center experience.

    abstract:INTRODUCTION:Aortoiliac pathology in kidney allograft recipients is not rare but treatment timing is controversial. As most publications on this topic are case reports its difficult to evaluate long-term outcomes of those clinical challenges. Herein we report long-term results of these procedures. METHODS:From 1970 to...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2009.00981.x

    authors: Tsivian M,Neri F,Nardo B,Bertelli R,Cavallari G,Fuga G,Faenza A

    更新日期:2009-03-01 00:00:00

  • The effect of sirolimus on sex hormone levels of male renal transplant recipients.

    abstract:BACKGROUND:It is unclear whether sirolimus, a newer immunosuppressive agent, widely used in renal transplantation, affects male sex hormone levels or sexual function. METHODS:Sex hormone profiles in male renal transplant recipients were obtained and compared between a sirolimus-treated group and a group not on sirolim...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00257.x

    authors: Lee S,Coco M,Greenstein SM,Schechner RS,Tellis VA,Glicklich DG

    更新日期:2005-04-01 00:00:00

  • Hyperhomocysteinemia and transplant coronary artery disease in cardiac transplant recipients.

    abstract:BACKGROUND:In cardiac transplant recipients, long-term survival may be limited by transplant coronary artery disease (TxCAD). Hyperhomocysteinemia (Hhcy) has been associated with vascular disease and is common in transplant recipients. The objective of this study was to determine the relationship between fasting homocy...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150407.x

    authors: Miner SE,Cole DE,Evrovski J,Verma A,Daly PA,Ross HJ

    更新日期:2001-08-01 00:00:00

  • Urinary nitrate excretion is increased in cardiac transplanted patients with acute graft rejection.

    abstract::Acute allograft rejection in patients after cardiac transplantation is associated with intense infiltration of inflammatory cells. It has been shown in animal studies that this inflammatory process is accompanied by an induction of nitric oxide syndrome (NOS) enzyme within the grafted organ. We sought to test the hypo...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Mügge A,Kurucay S,Böger RH,Bode-Böger SM,Schäfers HJ,Wahlers T,Frölich JC,Lichtlen PR

    更新日期:1996-06-01 00:00:00

  • Impact of the new fast track kidney allocation scheme for declined kidneys in the United Kingdom.

    abstract:INTRODUCTION:A "new" fast track kidney allocation scheme (FTKAS) was implemented in the UK in 2012 for offering of previously declined kidneys. We evaluated the impact of the FTKAS in utilization of declined kidneys and outcome. METHODS:Adult renal transplant centers were surveyed. Overall utilization was evaluated us...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12576

    authors: White AD,Roberts H,Ecuyer C,Brady K,Pathak S,Clark B,Hostert LH,Attia MS,Wellberry-Smith M,Hudson A,Ahmad N

    更新日期:2015-10-01 00:00:00

  • Prolonged cardiac allograft ischemic time--no impact on long-term survival but at what cost?

    abstract:INTRODUCTION:The aim of this paper was to review the outcomes of cardiac transplantation with regards to short- and long-term survival, focusing particularly on patients who receive organs with long ischemic times and the resource utilization necessary to support such patients through their postoperative period. METHO...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00644.x

    authors: Marasco SF,Esmore DS,Richardson M,Bailey M,Negri J,Rowland M,Kaye D,Bergin PJ

    更新日期:2007-05-01 00:00:00

  • Anti-IL-2R blockers comparing with polyclonal antibodies: Higher risk of rejection without negative mid-term outcomes after ABO-incompatible kidney transplantation.

    abstract::There is no recommendation regarding the type of induction therapy to use in ABO-incompatible (ABOi) kidney transplantation. The aim of this retrospective study was to compare the outcome of ABOi living donor kidney transplant (LDKT) recipients who received either polyclonal antibodies or anti-interleukin-2 receptor (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13681

    authors: Del Bello A,Divard G,Belliere J,Congy-Jolivet N,Lanfranco L,Ricard R,Delas A,Colombat M,Esposito L,Hebral AL,Cointault O,Lefaucheur C,Loupy A,Kamar N

    更新日期:2019-10-01 00:00:00

  • Kidney transplantation in the Hispanic population.

    abstract::Hispanic race and low socioeconomic status are established predictors of disparity in access to kidney transplantation. This single-center retrospective review was undertaken to determine whether Hispanic race predicted kidney transplant outcomes. A total of 720 patients underwent kidney transplantation from January 1...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12662

    authors: Matsuoka L,Alicuben E,Woo K,Cao S,Groshen S,Qazi Y,Smogorzewski M,Selby R,Alexopoulos S

    更新日期:2016-02-01 00:00:00

  • Association between increased-risk donor social behaviors and recipient outcomes after heart transplantation.

    abstract:BACKGROUND:This study aims to investigate the association between social behaviors of increased-risk donors (IRD) and recipient outcomes after heart transplantation. METHODS:The United Network for Organ Sharing (UNOS) database was queried to identify patients who received a heart transplant between 2004 and 2015. Pati...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13787

    authors: Okoh AK,Chan O,Schultheis M,Gupta M,Shah A,Gold J,Russo MJ,Lee LY,Camacho M

    更新日期:2020-03-01 00:00:00

  • A high antithymocyte globulin dose increases the risk of relapse after reduced intensity conditioning HSCT with unrelated donors.

    abstract::The study included 110 consecutive patients with hematological malignancies receiving fludarabine-based reduced intensity conditioning (RIC) and hematopoietic stem cell transplantation (HSCT) from matched unrelated donors. The median age was 55 yr (range 11-68) and all but 15 patients received peripheral blood stem ce...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12131

    authors: Remberger M,Ringdén O,Hägglund H,Svahn BM,Ljungman P,Uhlin M,Mattsson J

    更新日期:2013-07-01 00:00:00

  • A comparison of daclizumab to ATGAM induction in simultaneous pancreas-kidney transplant recipients on triple maintenance immunosuppression.

    abstract::Daclizumab (DAC) is a molecularly engineered humanized IgGa monoclonal Ab directed against the alpha chain of the interleukin-2 receptor (IL2R). Inhibiting the amplification of the immune response by blocking IL2R can reduce the frequency of acute rejection without the attendant risk of infection. The purpose of this ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.14040902.x

    authors: Rasaiah SB,Light JA,Sasaki TM,Currier CB

    更新日期:2000-08-01 00:00:00

  • Pattern of resolution of pulmonary hypertension, long-term allograft right ventricular function, and exercise capacity in high-risk heart transplant recipients listed under oral sildenafil.

    abstract::Unresponsive pulmonary hypertension (PH) implies poor posttransplant outcomes. Data on late adaptation of the right ventricle (RV) are still few. This study evaluated three-yr RV function and remodeling, exercise capacity, and hemodynamic data in a selected group of patients initially disqualified because of PH. Betwe...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12387

    authors: De Santo LS,Buonocore M,Agrusta F,Bancone C,Galdieri N,Romano G,Maiello C,Amarelli C

    更新日期:2014-07-01 00:00:00

  • Epidemiology, risk factors, and impact of bacterial infections on outcomes for pancreatic grafts.

    abstract::We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial in...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13333

    authors: Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

    更新日期:2018-08-01 00:00:00

  • The profile of inflammatory and metabolic response in children undergoing heart transplantation.

    abstract::Inflammatory and metabolic response is an important factor to determine clinical outcomes. However, it remains unknown in children undergoing heart transplantation (HTx). We examined the perioperative changes in the inflammatory and metabolic response markers C-reactive protein (CRP) and prealbumin (PA) in 38 heart-tr...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01566.x

    authors: Yu X,Larsen B,Urschel S,Cheung PY,Ross DB,Rebeyka I,West L,Li J

    更新日期:2012-03-01 00:00:00

  • The association of acute rejection vs recurrent glomerular disease with graft outcomes after kidney transplantation.

    abstract:BACKGROUND:It has been shown that glomerulonephritis (GN) recurrence affects graft survival more than acute rejection. Thus, we assessed allograft survival after biopsy-confirmed diagnosis of acute rejection or recurrent GN in current era of immunosuppression. METHODS:Allograft survival following a biopsy diagnosis of...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13738

    authors: Singh T,Astor BC,Zhong W,Mandelbrot DA,Maursetter L,Panzer SE

    更新日期:2019-12-01 00:00:00

  • The international prevalence and variability of nonadherence to the nonpharmacologic treatment regimen after heart transplantation: Findings from the cross-sectional BRIGHT study.

    abstract:INTRODUCTION:Heart transplant (HTx) recipients need to follow a complex therapeutic regimen. We assessed the international prevalence and variability in nonadherence to six nonpharmacologic treatment components (physical activity, sun protection, diet, alcohol use, nonsmoking, and outpatient follow-up visits). METHODS...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13280

    authors: Helmy R,Duerinckx N,De Geest S,Denhaerynck K,Berben L,Russell CL,Van Cleemput J,Crespo-Leiro MG,Dobbels F,BRIGHT study team.

    更新日期:2018-07-01 00:00:00

  • Increased risk of post-transplant diabetes mellitus despite early steroid discontinuation in Hispanic kidney transplant recipients.

    abstract::Early steroid discontinuation (ESD) has been associated with a lower incidence of post-transplant diabetes mellitus (PTDM). We retrospectively reviewed the incidence of PTDM in relation to racial groups in kidney transplant recipients treated with ESD. Between January 2002 and September 2003, 125 consecutive primary a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00383.x

    authors: Walczak DA,Calvert D,Jarzembowski TM,Testa G,Sankary HN,Thielke J,Oberholzer J,Benedetti E

    更新日期:2005-08-01 00:00:00

  • Role of pre-transplant marital status in renal transplant outcome.

    abstract:BACKGROUND:End-stage renal disease is associated with illness-induced disruptions that challenge patients and their families to accommodate and adapt. However, the impact of patients' marital status on kidney transplant outcome has never been studied. This project, based on data from United States Renal Data System (US...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00575.x

    authors: Naiman N,Baird BC,Isaacs RB,Koford JK,Habib AN,Wang BJ,Barenbaum LL,Goldfarb-Rumyantzev AS

    更新日期:2007-01-01 00:00:00

  • Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function.

    abstract:INTRODUCTION:Atherosclerosis is a serious complication and leading cause of mortality in renal transplant recipients (RTRs). Hyperlipidemia may be associated with progression of renal disease and chronic allograft dysfunction. Similarities in the pathogenesis of glomerulosclerosis and atherosclerosis have been proposed...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00162.x

    authors: Kahraman S,Kiykim AA,Altun B,Gençtoy G,Arici M,Gulsun M,Erdem Y,Yasavul U,Turgan C,Cağlar S

    更新日期:2004-06-01 00:00:00

  • Suggested guidelines for the use of tacrolimus in pancreas/kidney transplantation.

    abstract::As experience with tacrolimus (FK506, Prograf) accumulates and reduced rejection rates are increasingly demonstrated, some transplant centers are adopting tacrolimus-based primary immunosuppressive regimens for their patients undergoing pancreas/kidney transplantation. The guidelines provided in this article based on ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Gruessner RW,Bartlett ST,Burke GW,Stock PG

    更新日期:1998-06-01 00:00:00

  • Living-donor liver transplantation for congenital biliary atresia with porto-pulmonary hypertension and moderate or severe pulmonary arterial hypertension: Kyoto University experience.

    abstract::Porto-pulmonary hypertension with moderate or severe pulmonary arterial hypertension (PAH) is viewed as a contraindication to liver transplantation (LT) because of associated poor outcomes; however, patients with biliary atresia (BA) are generally good candidates for LT. Ten patients with moderate/severe PAH underwent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12415

    authors: Ogawa E,Hori T,Doi H,Segawa H,Uemoto S

    更新日期:2014-09-01 00:00:00

  • Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes.

    abstract::The main cause of late morbidity and mortality after lung transplantation is bronchiolitis obliterans syndrome (BOS). This study assesses the prevalence of gastroparesis among lung-transplant recipients and its association with BOS. The files of 139 patients who underwent nuclear gastric emptying studies before and/or...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01434.x

    authors: Raviv Y,D'Ovidio F,Pierre A,Chaparro C,Freeman M,Keshavjee S,Singer LG

    更新日期:2012-01-01 00:00:00

  • Donor-derived infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    abstract::These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation will review the current state of the art of donor-derived infections. Specifically, the guideline will summarize standardized definitions and approaches to defining imputability, updated data on the e...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13547

    authors: Wolfe CR,Ison MG,AST Infectious Diseases Community of Practice.

    更新日期:2019-09-01 00:00:00

  • Incidence of leukopenia and cytomegalovirus disease in kidney transplants treated with mycophenolate mofetil combined with low cyclosporine and steroid doses.

    abstract::Mycophenolate mofetil (MMF) combined with conventional cyclosporine and steroids doses efficiently prevents acute rejection in kidney transplants. However, this regimen has been associated with an increased incidence of cytomegalovirus (CMV) disease and leukopenia, specially in patients receiving MMF at 3 g/d, suggest...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Moreso F,Serón D,Morales JM,Cruzado JM,Gil-Vernet S,Pérez JL,Fulladosa X,Andrés A,Grinyó JM

    更新日期:1998-06-01 00:00:00

  • Impact of dose reductions on efficacy outcome in heart transplant patients receiving enteric-coated mycophenolate sodium or mycophenolate mofetil at 12 months post-transplantation.

    abstract::Mycophenolic acid (MPA) dose reduction is associated with increased risk of rejection and graft loss in renal transplantation. This analysis investigated the impact of MPA dose changes with enteric-coated mycophenolate sodium (EC-MPS) or mycophenolate mofetil (MMF) in de novo heart transplant recipients. In a 12-month...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-0012.2008.00887.x

    authors: Segovia J,Gerosa G,Almenar L,Livi U,Viganò M,Arizón JM,Yonan N,Di Salvo TG,Renlund DG,Kobashigawa JA,ERL 2401 Study Group.

    更新日期:2008-11-01 00:00:00

  • Screening for asymptomatic bacteruria at one month after adult kidney transplantation: Clinical factors and implications.

    abstract:OBJECTIVE:Urinary tract infections (UTIs) account for significant morbidity after kidney transplantation (KT). Screening for asymptomatic bacteruria (AB) has proven to be beneficial in certain population including pregnant women; however, it is not well-studied in KT population. We reviewed the incidence, clinical feat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12954

    authors: Goh YSB,Deng Z,Cheong PSC,Raman L,Goh THA,Vathsala A,Tiong HY

    更新日期:2017-05-01 00:00:00

  • Access to living donor transplantation for Aboriginal recipients: a study of living donor presentation and exclusion.

    abstract::Aboriginals experience high rates of end-stage renal disease (ESRD) and are less likely to receive a kidney transplant from a living donor. We hypothesized that higher rates of hypertension and diabetes in Aboriginal communities would result in fewer potential living donors coming forward and more exclusions for medic...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01491.x

    authors: Dunsmore S,Karpinski M,Young A,Storsley L

    更新日期:2011-11-01 00:00:00

  • Multiplexed color-coded probe-based gene expression assessment for clinical molecular diagnostics in formalin-fixed paraffin-embedded human renal allograft tissue.

    abstract::Histopathologic diagnoses in transplantation can be improved with molecular testing. Preferably, molecular diagnostics should fit into standard-of-care workflows for transplant biopsies, that is, formalin-fixed paraffin-embedded (FFPE) processing. The NanoString(®) gene expression platform has recently been shown to w...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12689

    authors: Adam B,Afzali B,Dominy KM,Chapman E,Gill R,Hidalgo LG,Roufosse C,Sis B,Mengel M

    更新日期:2016-03-01 00:00:00

  • LabMELD-based organ allocation increases total costs of liver transplantation: a single-center experience.

    abstract:INTRODUCTION:In 2006, model for end-stage liver disease (MELD)-based allocation was implemented in the Eurotransplant (ET) region. Sick patients, who in general require more resources, are prioritized. In this analysis, the effect of MELD on costs for liver transplantation (LTx) was assessed. METHODS:Total costs for L...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2011.01483.x

    authors: Bruns H,Hillebrand N,Schneider T,Hinz U,Fischer L,Schmidt J,Goldschmidt AJ,Schemmer P

    更新日期:2011-09-01 00:00:00