The effect of sirolimus on sex hormone levels of male renal transplant recipients.

Abstract:

BACKGROUND:It is unclear whether sirolimus, a newer immunosuppressive agent, widely used in renal transplantation, affects male sex hormone levels or sexual function. METHODS:Sex hormone profiles in male renal transplant recipients were obtained and compared between a sirolimus-treated group and a group not on sirolimus in a cross-sectional study. Both groups also completed a sexual dysfunction questionnaire. RESULTS:Sixty-six subjects were evaluated, 32 in the sirolimus group and 34 in the control group. Total testosterone level was significantly lower in the sirolimus group than the control group (393.3 +/- 188 vs. 537.4 +/-232 pg/mL; p = 0.08) while follicle stimulating hormone and luteinizing hormone levels were significantly higher in the sirolimus group (12.8 +/- 14 vs. 6.0 +/- 5, p = 0.013; 10.9 +/- 14 vs. 4.7 +/- 4, p = 0.018, respectively). There was a significant negative correlation between 24-h sirolimus trough and total testosterone levels (p < 0.03). By multiple regression analysis, use of sirolimus was independently associated with decreased total testosterone level. There was no significant difference in subjective sexual dysfunction as assessed by questionnaire scores between the two groups. There was no correlation between questionnaire scores and total testosterone level. CONCLUSION:Sirolimus is associated with decreased total testosterone levels in male renal transplant recipients. It is unclear whether sirolimus may affect other aspects of sexual function.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Lee S,Coco M,Greenstein SM,Schechner RS,Tellis VA,Glicklich DG

doi

10.1111/j.1399-0012.2005.00257.x

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

162-7

issue

2

eissn

0902-0063

issn

1399-0012

pii

CTR257

journal_volume

19

pub_type

杂志文章
  • Adverse drug reaction driven immunosuppressive drug manipulations: a single-center comparison of enteric-coated mycophenolate sodium vs. mycophenolate mofetil.

    abstract:UNLABELLED:Enteric-coated mycophenolate sodium (MPS) has been developed to help circumvent the upper gastrointestinal side-effects of mycophenolic acid by facilitating drug release in the small intestine. Many questions regarding the side-effect profile of MPS remain. Therefore, the purpose of this study is to review a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00820.x

    authors: Hardinger KL,Hebbar S,Bloomer T,Murillo D

    更新日期:2008-09-01 00:00:00

  • Effectiveness and safety of the conversion to MeltDose® extended-release tacrolimus from other formulations of tacrolimus in stable kidney transplant patients: A retrospective study.

    abstract::Tacrolimus is the cornerstone of immunosuppressive therapy after kidney transplantation. Its narrow therapeutic window mandates serum level strict monitoring and dose adjustments to ensure the optimal risk-benefit balance. This observational retrospective study analyzed the effectiveness and safety of conversion from ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13767

    authors: Sánchez Fructuoso A,Ruiz JC,Franco A,Diekmann F,Redondo D,Calviño J,Serra N,Aladrén MJ,Cigarrán S,Manonelles A,Ramos A,Gómez G,González Posada JM,Andrés A,Beneyto I,Muñiz AL,Perelló M,Lauzurica R

    更新日期:2020-01-01 00:00:00

  • Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

    abstract:PURPOSE:Frail patients who undergo renal transplantation (RT) have more complications; however, little is known if these patients can sustain the wait to RT. We used the Timed Up and Go Test (TUGT) and Montreal Cognitive Assessment (MoCA) to determine outcomes of RT candidates. METHODS:In this retrospective study, 526...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14161

    authors: Bozhilov K,Vo KB,Wong LL

    更新日期:2020-11-20 00:00:00

  • Kidney transplant referral practices in southeastern dialysis units.

    abstract:BACKGROUND:The Southeastern Kidney Transplant Coalition was created in 2010 to improve kidney transplant (KTx) rates in Georgia, North Carolina, and South Carolina. To identify dialysis staff-reported barriers to transplant, the Coalition developed a survey of dialysis providers in the region. METHODS:All dialysis uni...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12693

    authors: Browne T,Patzer RE,Gander J,Amamoo MA,Krisher J,Sauls L,Pastan S

    更新日期:2016-04-01 00:00:00

  • Methamphetamine use in deceased kidney donors impairs one-yr graft function.

    abstract:BACKGROUND:Methamphetamine (MA) has cumulative deleterious effects on multiple organ systems. A history of MA exposure in kidney donors may affect adversely graft function in recipients. METHODS:Between September 2000 and March 2004, all deceased kidney donors were identified from the local registry (97 donors). Twent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00703.x

    authors: Inouye DS,Kickertz K,Wong LL

    更新日期:2007-09-01 00:00:00

  • Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral.

    abstract::Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion deliv...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Ritschel WA

    更新日期:1996-08-01 00:00:00

  • Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study.

    abstract:BACKGROUND:Short-term survival after kidney transplantation is excellent, but long-term survival remains low and is equivalent to non-end-stage renal disease patients with many invasive malignancies. The aim of the study was to explore vitamin D status in the early phase after transplantation as a prognostic marker for...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13517

    authors: Thorsen IS,Bleskestad IH,Åsberg A,Hartmann A,Skadberg Ø,Brede C,Ueland T,Pasch A,Reisaeter AV,Gøransson LG

    更新日期:2019-05-01 00:00:00

  • Brain natriuretic peptide and right heart dysfunction after heart transplantation.

    abstract::Heart transplantation (HT) should normalize cardiac endocrine function, but brain natriuretic peptide (BNP) levels remain elevated after HT, even in the absence of left ventricular hemodynamic disturbance or allograft rejection. Right ventricle (RV) abnormalities are common in HT recipients (HTx), as a result of engra...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12969

    authors: Talha S,Charloux A,Piquard F,Geny B

    更新日期:2017-06-01 00:00:00

  • The impact of diabetes mellitus and glycemic control on clinical outcomes following liver transplant for hepatitis C.

    abstract::Hepatitis C is the leading indication for liver transplantation in the USA and recurrence is universal. The impact of preexisting diabetes, new-onset diabetes after transplant (NODAT), and glycemic control on fibrosis progression has not been studied. This retrospective longitudinal cohort study included adult liver r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12391

    authors: Morbitzer KA,Taber DJ,Pilch NA,Meadows HB,Fleming JN,Bratton CF,McGillicuddy JW,Baliga PK,Chavin KD

    更新日期:2014-08-01 00:00:00

  • Plasma magnesium during human liver transplantation.

    abstract::Patients with severe liver disease and accompanying malnutrition may exhibit electrolyte disturbances including the magnesium balance. In 18 patients plasma magnesium (p-Mg) was determined at the start of the liver transplantation and during the anhepatic and reperfusion phases of the operation. The blood loss was 6.9...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Skak C,Ejlersen E,Mogensen T,Winkel P,Secher NH

    更新日期:1996-04-01 00:00:00

  • Role of pre-transplant marital status in renal transplant outcome.

    abstract:BACKGROUND:End-stage renal disease is associated with illness-induced disruptions that challenge patients and their families to accommodate and adapt. However, the impact of patients' marital status on kidney transplant outcome has never been studied. This project, based on data from United States Renal Data System (US...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00575.x

    authors: Naiman N,Baird BC,Isaacs RB,Koford JK,Habib AN,Wang BJ,Barenbaum LL,Goldfarb-Rumyantzev AS

    更新日期:2007-01-01 00:00:00

  • Risk factors for native kidney dysfunction in patients with abdominal multivisceral/small bowel transplantation.

    abstract::Kidney dysfunction is a recognized complication after non-renal solid organ transplantation, particularly after intestinal transplant. In our study, we reviewed data on 33 multivisceral transplant (MVT)- and 15 isolated small bowel (ISB)-transplant patients to determine risk factors for kidney dysfunction. Kidney func...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01672.x

    authors: Suzuki M,Mujtaba MA,Sharfuddin AA,Yaqub MS,Mishler DP,Faiz S,Vianna RM,Mangus RS,Tector JA,Taber TE

    更新日期:2012-07-01 00:00:00

  • Increased risk of post-transplant diabetes mellitus despite early steroid discontinuation in Hispanic kidney transplant recipients.

    abstract::Early steroid discontinuation (ESD) has been associated with a lower incidence of post-transplant diabetes mellitus (PTDM). We retrospectively reviewed the incidence of PTDM in relation to racial groups in kidney transplant recipients treated with ESD. Between January 2002 and September 2003, 125 consecutive primary a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00383.x

    authors: Walczak DA,Calvert D,Jarzembowski TM,Testa G,Sankary HN,Thielke J,Oberholzer J,Benedetti E

    更新日期:2005-08-01 00:00:00

  • Analysis of preexisting baseline kidney lesions revealed by biopsy in living kidney donors: relationship with clinical parameters at the time of donation.

    abstract::Because the safety of living organ donors is essential, we have been performing donor kidney biopsy before donation in cases where decision-making regarding suitability is marginal. To clarify the degree to which pathological change in the kidney can be predicted on the basis of clinical data obtained non-invasively, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01276.x

    authors: Okamoto M,Koshino K,Nobori S,Ushigome H,Okajima H,Urasaki K,Yoshimura N

    更新日期:2010-07-01 00:00:00

  • Kidney transplantation in patients with severe preoperative hypertension.

    abstract:BACKGROUND:Severe systemic hypertension (HTN) is a risk factor for perioperative cardiovascular complications; however, its impact at the time of kidney transplantation (KTX) is not well defined. METHODS:A retrospective cohort study of adult kidney-only transplant recipients between October 2009 and December 2012 was ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12579

    authors: Ajaimy M,Lubetzky M,Kamal L,Gupta A,Dunn C,de Boccardo G,Akalin E,Kayler L

    更新日期:2015-09-01 00:00:00

  • Pneumocystis carinii pneumonia after liver transplantation in adults.

    abstract::Proven Pneumocystis carinii pneumonia (PCP) occurred in 8 (5.2%) of 154 adult liver transplant recipients between January 1986 and December 1992. The interval between transplantation and PCP ranged from 69 to 131 days with a mean of 95 days (SD 20 days). The PaO2 breathing room air at diagnosis ranged from 40 mmHg to ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Hayes MJ,Torzillo PJ,Sheil AG,McCaughan GW

    更新日期:1994-12-01 00:00:00

  • Interleukin 6 at reperfusion: A potent predictor of hepatic and extrahepatic early complications after liver transplantation.

    abstract:BACKGROUND AND AIMS:Ischemia-reperfusion injury impacts early liver graft function. Interleukin 6 (IL-6) as early as at reperfusion has shown to predict in-hospital complications, but its impact on vascular complications and long-term outcomes is not ascertained. METHODS:A retrospective study was conducted on all cons...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13357

    authors: Faitot F,Besch C,Lebas B,Addeo P,Ellero B,Woehl-Jaegle ML,Namer IJ,Bachellier P,Freys G

    更新日期:2018-09-01 00:00:00

  • Cardiac diastolic dysfunction in renal-transplant recipients is associated with increased circulating Adrenomedullin.

    abstract:BACKGROUND:Renal transplantation is an excellent therapeutic alternative for end-stage renal diseases. Nevertheless, the cardiac function is often impaired in renal-transplant patients (RTR) and importantly determines their prognosis. Adrenomedullin (ADM), a peptide involved in cardiovascular homeostasis, is believed t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00486.x

    authors: Geny B,Ellero B,Chakfé N,Kretz JG,Brandenberger G,Piquard F

    更新日期:2006-05-01 00:00:00

  • Renal allograft outcomes following early corticosteroid withdrawal in Hispanic transplant recipients.

    abstract:BACKGROUND:Renal transplant outcomes in Hispanics have been conflicting regarding acute rejection (AR) and allograft survival. Additionally, the feasibility of early corticosteroid withdrawal (ECW) regimens among Hispanics has not been adequately addressed. The purpose of this study is to report outcomes following ECW ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12218

    authors: Afaneh C,Cheng E,Aull MJ,Watkins AC,Kim J,Leeser DB,Kapur S

    更新日期:2013-11-01 00:00:00

  • Idiopathic interstitial pneumonia following stem cell transplantation.

    abstract::Idiopathic interstitial pneumonia (IIP) can occur after stem cell transplantation, but the aetiology is unknown. Based on the association between angiitis syndrome and Helicobacter pylori infection, we identified possible risk factors common to these two conditions. Among 83 patients who underwent stem cell transplant...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.00053.x

    authors: Yamaguchi N,Takatsuka H,Wakae T,Okada M,Fujimori Y,Okamoto T,Kakishita E,Hara H

    更新日期:2003-08-01 00:00:00

  • Reviews on mysterious vascular endothelial cells in renal allografts.

    abstract::Endothelial cells (ECs) are involved in allograft rejection and are prime targets, but also key players. HLA antigens are the most prominent targets of alloantibodies in transplantation. Alloantibodies against other antigens such as ABO blood group antigens and non-HLA antigens could also be demonstrated. Alloantibodi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2012.01675.x

    authors: Yamaguchi Y

    更新日期:2012-07-01 00:00:00

  • Antiproteinuric efficacy of fosinopril after renal transplantation is determined by the extent of vascular and tubulointerstitial damage.

    abstract:BACKGROUND:Angiotensin converting enzyme (ACE) inhibitors have been successfully used for treatment of proteinuria after renal transplantation (RTx). Factors possibly responsible for the great inter-patient variance of the antiproteinuric effect (APE) have not yet been investigated in renal-transplanted patients. METH...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Lufft V,Kliem V,Hamkens A,Bleck JS,Eisenberger U,Petersen R,Ehlerding G,Maschek H,Pichlmayr R,Brunkhorst R

    更新日期:1998-10-01 00:00:00

  • Differential contribution of graft and recipient to perioperative TNF-alpha, IL-1 beta, IL-6 and IL-8 levels and correlation with early graft function in clinical liver transplantation.

    abstract::Cytokines, produced by both the recipient and the newly vascularized allograft, are central mediators in the inflammatory response to allografted tissue. This study examines the relationship between pre- and intraoperative levels of TNF, IL-1, IL-6, and IL-8 and hepatic allograft function in the early postoperative pe...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Boros P,Suehiro T,Curtiss S,Sheiner P,Emre S,Guy S,Schwartz ME,Miller CM

    更新日期:1997-12-01 00:00:00

  • Attitudes of commercial renal transplant recipients toward renal transplantation in India.

    abstract::Renal transplantation offers patients with end-stage renal disease the best opportunity for rehabilitation and long-term survival. However, there is a critical shortage of transplantable kidneys worldwide. This plays well into the hands of transplanters and entrepreneurs involved in commercial renal transplantation, p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Qunibi W,Abulrub D,Shaheen F,el-Din AB,Alfurayh O,Almeshari K

    更新日期:1995-08-01 00:00:00

  • Reduced dose Thymoglobulin, tacrolimus, and mofetil mycophenolate results in excellent solitary pancreas transplantation outcomes.

    abstract:BACKGROUND:Graft survival following solitary pancreas transplantation has traditionally lagged behind that of simultaneous pancreas-kidney transplants. Thymoglobulin (TMG), a polyclonal rabbit-derived antilymphocyte antibody was originally introduced as treatment for acute rejection of renal allografts. However, data r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02031.x

    authors: Tan M,Cantarovich M,Mangel R,Paraskevas S,Fortier M,Metrakos P

    更新日期:2002-12-01 00:00:00

  • Liver transplantation in patients aged 65 and over: a case-control study.

    abstract:INTRODUCTION:The average age of patients undergoing liver transplantation (LT) is consistently increasing. The aim of this case-control study is to evaluate survival and outcome of patients ≥65 yr compared to younger patients undergoing LT. MATERIALS AND METHODS:From 10/00 to 4/08 we performed 330 primary LT, 31 (9.4%...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01230.x

    authors: Montalti R,Rompianesi G,Di Benedetto F,Ballarin R,Gerring RC,Busani S,De Pietri L,De Ruvo N,Iemmolo RM,Guerrini GP,Smerieri N,Gerunda GE

    更新日期:2010-09-01 00:00:00

  • Care of international living kidney donor candidates in the United States: A survey of contemporary experience, practice, and challenges.

    abstract::The evaluation and care of non-US citizen, non-US residents who wish to come to the United States to serve as international living kidney donors (ILKDs) can pose unique challenges. We surveyed US transplant programs to better understand practices related to ILKD care. We distributed the survey by email and professiona...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14064

    authors: Lentine KL,Motter JD,Henderson ML,Hays RE,Shukhman E,Hunt J,Al Ammary F,Kumar V,LaPointe Rudow D,Van Pilsum Rasmussen SE,Nishio-Lucar AG,Schaefer HM,Cooper M,Mandelbrot DA

    更新日期:2020-11-01 00:00:00

  • Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy.

    abstract::We investigated tolerability and efficacy of ezetimibe treatment (10 mg/d) in 25 heart allograft recipients already on stable statin therapy. Total cholesterol (TC), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C), triglycerides (TG), immunosuppressant drug levels, laboratory and clinical parameters ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2008.00838.x

    authors: Konstandin MH,Blessing E,Doesch A,Ammon K,Koch A,Wabnitz GH,Gleissner CA,Remppis A,Katus HA,Dengler TJ

    更新日期:2008-09-01 00:00:00

  • Elevated calcium phosphate product after renal transplantation is a risk factor for graft failure.

    abstract:BACKGROUND:Abnormal mineral metabolism is not uncommon after renal transplant (TXP). In dialysis patients, elevated serum phosphorous (P), calcium (Ca), CaP product, and parathyroid hormone (PTH) are associated with increased morbidity and mortality. The effect of these abnormalities on recipient and graft survival aft...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00690.x

    authors: Egbuna OI,Taylor JG,Bushinsky DA,Zand MS

    更新日期:2007-07-01 00:00:00

  • Two-stage liver transplantation: an effective procedure in urgent conditions.

    abstract::Temporary portocaval shunt and total hepatectomy is a technique used in the presence of toxic liver syndrome because of fulminant hepatic failure, hepatic trauma, primary non-function (PNF), and eclampsia. We performed this technique on four patients. An indication for anhepatic state was severe hemodynamic instabilit...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01118.x

    authors: Montalti R,Busani S,Masetti M,Girardis M,Di Benedetto F,Begliomini B,Rompianesi G,Rinaldi L,Ballarin R,Pasetto A,Gerunda GE

    更新日期:2010-01-01 00:00:00