Differential contribution of graft and recipient to perioperative TNF-alpha, IL-1 beta, IL-6 and IL-8 levels and correlation with early graft function in clinical liver transplantation.

abstract：:Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion deliv...

journal_title：Clinical transplantation

authors： Ritschel WA

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Quantitative analysis of the Epstein-Barr virus (EBV) genome has been recently reported to be helpful for early identification of EBV viremia which could reduce the risk of post-transplantation lymphoproliferative disorder (PTLD). AIM:To demonstrate the significance of serial monitoring of EBV genome load b...

journal_title：Clinical transplantation

authors： Matsukura T,Yokoi A,Egawa H,Kudo T,Kawashima M,Hirata Y,Tanaka H,Kagajo K,Wada H,Tanaka K

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Angiotensin converting enzyme (ACE) inhibitors have been successfully used for treatment of proteinuria after renal transplantation (RTx). Factors possibly responsible for the great inter-patient variance of the antiproteinuric effect (APE) have not yet been investigated in renal-transplanted patients. METH...

journal_title：Clinical transplantation

authors： Lufft V,Kliem V,Hamkens A,Bleck JS,Eisenberger U,Petersen R,Ehlerding G,Maschek H,Pichlmayr R,Brunkhorst R

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:The clinical consequences of type 1 diabetes mellitus (IDDM) include diabetic triopathy: retinopathy, nephropathy, and neuropathy, as well as microangiopathy, accelerated atherosclerotic disease, and hypercoagulability. The etiology of the hypercoagulability is multifactorial, involving various clotting fact...

journal_title：Clinical transplantation

authors： Burke GW 3rd,Ciancio G,Figueiro J,Buigas R,Olson L,Roth D,Kupin W,Miller J

更新日期：2004-08-01 00:00:00

abstract：:Mycophenolic acid (MPA) dose reduction is associated with increased risk of rejection and graft loss in renal transplantation. This analysis investigated the impact of MPA dose changes with enteric-coated mycophenolate sodium (EC-MPS) or mycophenolate mofetil (MMF) in de novo heart transplant recipients. In a 12-month...

journal_title：Clinical transplantation

authors： Segovia J,Gerosa G,Almenar L,Livi U,Viganò M,Arizón JM,Yonan N,Di Salvo TG,Renlund DG,Kobashigawa JA,ERL 2401 Study Group.

更新日期：2008-11-01 00:00:00

abstract：:The progression of HCV-related disease is particularly aggressive in the post-transplantation setting. Recipients with recurrent HCV infection undergo repeated liver biopsies in order to estimate disease progression. A strong association was found between serum immunoglobulins levels and hepatic fibrosis in non-transp...

journal_title：Clinical transplantation

authors： Schmilovitz-Weiss H,Cohen M,Pappo O,Sulkes J,Braun M,Tur-Kaspa R,Ben-Ari Z

更新日期：2007-05-01 00:00:00

abstract：:Although patients within a transplant program are awaiting or have received disease modifying or curative treatment, they are also facing advanced illness and the possibility of death. The involvement of specialized palliative care services for these patients may improve symptom management and facilitate advance care ...

journal_title：Clinical transplantation

authors： Wentlandt K,Dall'Osto A,Freeman N,Le LW,Kaya E,Ross H,Singer LG,Abbey S,Clarke H,Zimmermann C

更新日期：2016-12-01 00:00:00

abstract：:The donation of organs and tissues for the benefit of another person is an altruistic act and one that is a guaranteed option for the next-of-kin through various national Required Request legislations. At the Washington Hospital Center we have developed an approach that permits organ recovery from non-heart beating do...

journal_title：Clinical transplantation

authors： Kowalski AE,Light JA,Ritchie WO,Sasaki TM,Callender CO,Gage F

更新日期：1996-12-01 00:00:00

abstract：INTRODUCTION:A long-term prospective randomized trial evaluating alemtuzumab, a humanized anti-CD52 monoclonal antibody, in a predominantly non-Caucasian population has yet to be reported. METHODS:Ninety deceased donor (DD) first renal transplant recipients were randomized into three different antibody induction group...

journal_title：Clinical transplantation

authors： Ciancio G,Burke GW,Gaynor JJ,Roth D,Kupin W,Rosen A,Cordovilla T,Tueros L,Herrada E,Miller J

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Smoking is a major public health issue, and its effect on cardiovascular outcomes is well established. This study evaluates the impact of donor smoking on heart transplant (HT) outcomes. METHODS:HT recipients between January 1, 2005, and December 31, 2016, with known donor smoking status were queried from the ...

journal_title：Clinical transplantation

authors： Hussain Z,Yu M,Wozniak A,Kim D,Krepostman N,Liebo M,Raichlin E,Heroux A,Joyce C,Ilias-Basha H

更新日期：2020-10-23 00:00:00

abstract：:Early measures of graft function are increasingly used to assess efficacy in clinical trials of kidney transplant immunosuppression. This study aimed to assess the variability and quality of reporting of these endpoints in contemporary trials. Data regarding renal function endpoints were extracted from 213 reports fro...

journal_title：Clinical transplantation

authors： Knight SR,Hussain S

更新日期：2016-12-01 00:00:00

abstract：:Acute allograft glomerulopathy (AAG) characterized by hypercellularity, enlargement of endothelial cells, infiltration of glomeruli by mononuclear cells and webs of PAS-positive material has been reported as an unusual but distinct form of acute rejection in kidney transplant recipients. We present a case of persisten...

journal_title：Clinical transplantation

authors： Katafuchi R,Masutani K,Mizumasa T,Fujita E,Tanaka H,Ikeda K,Yanase T,Ando T,Fujimi S

更新日期：2001-01-01 00:00:00

abstract：:The practice of uncontrolled donation after cardiac death (uDCD) has been met with tepid interest within the United States transplant community. Hesitancy stems largely from fears of eroding public trust due to complex ethical issues involving consent. Beyond ethical concerns, uDCD creates unique logistic challenges t...

journal_title：Clinical transplantation

authors： Choudhury RA,Prins K,Moore HB,Yoeli D,Kam A,Nydam TL

更新日期：2019-03-01 00:00:00

abstract：BACKGROUNDS:Recurrent hepatitis C virus (HCV) infection is universal post-transplantation. Fibrosis (F) stage ≥2 at 12 months identifies patients with rapid fibrosis progression. Antiviral therapy (AVT) remains the only option to attenuate fibrosis progression. We hypothesized that CXCL10 levels can distinguish between...

journal_title：Clinical transplantation

authors： Joshi D,Carey I,Foxton M,Al-Freah M,Bruce M,Heaton N,Quaglia A,O'Grady J,Aluvihare V,Agarwal K

更新日期：2014-05-01 00:00:00

abstract：:Because the safety of living organ donors is essential, we have been performing donor kidney biopsy before donation in cases where decision-making regarding suitability is marginal. To clarify the degree to which pathological change in the kidney can be predicted on the basis of clinical data obtained non-invasively, ...

journal_title：Clinical transplantation

authors： Okamoto M,Koshino K,Nobori S,Ushigome H,Okajima H,Urasaki K,Yoshimura N

更新日期：2010-07-01 00:00:00

abstract：:After cardiac transplant, there is often development of restrictive cardiac physiology. Little is known about the factors that contribute to this physiology and its correlation with pathology. Heart retransplantation provides a valuable opportunity to further understand this relationship. In this study, we investigate...

journal_title：Clinical transplantation

authors： Kobashigawa JA,Itagaki BK,Razi RR,Patel JK,Chai W,Kawano MA,Goldstein Z,Kittleson MM,Fishbein MC

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Although innate immunity is crucial to host defense against pathogens, the extent to which innate immune mechanisms participate in the rejection of allogenic tissues in humans is unknown. We hypothesize that activation of innate immunity through Toll-like receptors (TLRs) critically regulates the development...

journal_title：Clinical transplantation

authors： Palmer SM,Burch LH,Mir S,Smith SR,Kuo PC,Herczyk WF,Reinsmoen NL,Schwartz DA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Everolimus (EVL) and sirolimus (SRL) were introduced into immunosuppressive regimens, in an attempt to replace or reduce the dose of the nephrotoxic calcineurin inhibitors (CNI). In our institution, due to an administrative decision, conversion from SRL to EVL, was carried out, providing us the opportunity t...

journal_title：Clinical transplantation

authors： Carvalho C,Coentrão L,Bustorff M,Patrício E,Sampaio S,Santos J,Oliveira G,Pestana M

更新日期：2011-07-01 00:00:00

abstract：:Simultaneous pancreas-kidney transplantation is an established procedure for patients with type I diabetes and end-stage renal disease. Continuous advances in the operation techniques with consequent reduction of perioperative morbidity and mortality and the introduction of modern immunosuppressive agents improved not...

journal_title：Clinical transplantation

authors： Schmied BM,Müller SA,Mehrabi A,Welsch T,Büchler MW,Zeier M,Schmidt J

更新日期：2006-01-01 00:00:00

abstract：:Early steroid discontinuation (ESD) has been associated with a lower incidence of post-transplant diabetes mellitus (PTDM). We retrospectively reviewed the incidence of PTDM in relation to racial groups in kidney transplant recipients treated with ESD. Between January 2002 and September 2003, 125 consecutive primary a...

journal_title：Clinical transplantation

authors： Walczak DA,Calvert D,Jarzembowski TM,Testa G,Sankary HN,Thielke J,Oberholzer J,Benedetti E

更新日期：2005-08-01 00:00:00

abstract：:Vascular complications remain a significant source of morbidity after pancreatic transplantation. We describe a pseudoaneurysm of the superior mesenteric artery (SMA) with an arteriovenous fistula (AVF) involving the SMA and the superior mesenteric vein (SMV) discovered and treated surgically in the second week after ...

journal_title：Clinical transplantation

authors： Khan TF,Ciancio G,Burke GW 3rd,Sfakianakis GN,Miller J

更新日期：1999-06-01 00:00:00

abstract：:We herein report the first case of immunosuppression-associated thrombotic microangiopathy (TMA) in which an extrarenal graft was primarily affected by the characteristic microvascular lesions. Although TMA is a well-known complication of cyclosporine (CSA) or tacrolimus therapy in renal and extrarenal (liver, heart, ...

journal_title：Clinical transplantation

authors： Humar A,Jessurun J,Sharp HL,Gruessner RW

更新日期：1998-12-01 00:00:00

abstract：UNLABELLED: BACKGROUND:Rabbit anti-thymocyte globulin (rATG) induction reduces reperfusion injury and improves renal function in kidney recipients by means of properties unrelated to T-cell lysis. Here, we analyze intensive rATG induction (single dose, rATG(S) , vs. divided dose, rATG(D) ) for improved renal function ...

journal_title：Clinical transplantation

authors： Stevens RB,Lane JT,Boerner BP,Miles CD,Rigley TH,Sandoz JP,Nielsen KJ,Skorupa JY,Skorupa AJ,Kaplan B,Wrenshall LE

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:It is unclear whether sirolimus, a newer immunosuppressive agent, widely used in renal transplantation, affects male sex hormone levels or sexual function. METHODS:Sex hormone profiles in male renal transplant recipients were obtained and compared between a sirolimus-treated group and a group not on sirolim...

journal_title：Clinical transplantation

authors： Lee S,Coco M,Greenstein SM,Schechner RS,Tellis VA,Glicklich DG

更新日期：2005-04-01 00:00:00

abstract：:Granulomatous interstitial nephritis (GIN) is a rare histologic diagnosis in renal allografts. We report three cases with GIN. Case 1: a 37-yr-old woman received a kidney from her mother. On follow-up 15 months later, serum creatinine was increased and a graft biopsy showed epithelioid granuloma in the center of massi...

journal_title：Clinical transplantation

authors： Hotta K,Fukasawa Y,Sasaki H,Seki T,Togashi M,Harada H

更新日期：2012-07-01 00:00:00

abstract：:The majority of kidney transplant recipients die from cardiovascular events. Physical activity may be a modifiable risk factor for cardiovascular disease following transplant. The goal of our study was to examine adherence to a physical activity intervention following kidney transplant and its impact on metabolic para...

journal_title：Clinical transplantation

authors： Lorenz EC,Amer H,Dean PG,Stegall MD,Cosio FG,Cheville AL

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) and tacrolimus (Tac) in heart transplantation (HTx) have been compared but with certain drawbacks. We compared both drugs in a prospective analysis with medium-term follow-up. METHODS:Hundred and six patients were randomized to receive CsA or Tac (53 per group). Target levels of CsA were ...

journal_title：Clinical transplantation

authors： Sánchez-Lázaro IJ,Almenar L,Martínez-Dolz L,Buendía-Fuentes F,Agüero J,Navarro-Manchón J,Vicente JL,Salvador A

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Increased pulmonary vascular resistance (PVR) is associated with increased right ventricular failure and mortality after heart transplantation. METHODS:In this prospective study, 22 patients considered high-risk candidates for heart transplantation because of severe pulmonary hypertension (PVR = 6 ± 2 Wood ...

journal_title：Clinical transplantation

authors： Perez-Villa F,Farrero M,Cardona M,Castel MA,Tatjer I,Penela D,Vallejos I

更新日期：2013-01-01 00:00:00

abstract：:Acute rejection (AR) superimposed upon delayed graft function (DGF) following renal transplantation worsens graft outcomes. However, risk factors for AR in patients displaying DGF remain unclear. In this study, 71 patients displaying DGF >/= 5 d were investigated. All received cyclosporine, adjunctive azathioprine or ...

journal_title：Clinical transplantation

authors： Moore J,Tan K,Cockwell P,Krishnan H,McPake D,Ready A,Mellor S,Hamsho A,Ball S,Lipkin G,Borrows R

更新日期：2008-09-01 00:00:00

abstract：:Transplantation tolerance is the ultimate goal of organ transplantation. Natural regulatory T cells (Treg) have been expected to reach clinical applications for tolerance induction because their initial description. More than ten yr later, Treg have started moving from experimental animal models into clinical applicat...

journal_title：Clinical transplantation

authors： Fritzsching E,Kunz P,Maurer B,Pöschl J,Fritzsching B

更新日期：2009-12-01 00:00:00