Analysis of preexisting baseline kidney lesions revealed by biopsy in living kidney donors: relationship with clinical parameters at the time of donation.

Abstract:

:Because the safety of living organ donors is essential, we have been performing donor kidney biopsy before donation in cases where decision-making regarding suitability is marginal. To clarify the degree to which pathological change in the kidney can be predicted on the basis of clinical data obtained non-invasively, we analyzed preexisting lesions found by one-h biopsy in 76 living kidney donors, and compared the findings with clinical parameters at the time of donation. Pathological change in living kidney donors was correlated to some extent with predonation clinical parameters including age, serum creatinine, estimated glomerular filtration rate and presence of hypertension, while the lesions influenced by glucose intolerance were not completely correlated with the results of oral glucose tolerance test. A follow-up study will be required to determine whether these mild histological findings at the time of donation influence long-term outcome in the donor.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Okamoto M,Koshino K,Nobori S,Ushigome H,Okajima H,Urasaki K,Yoshimura N

doi

10.1111/j.1399-0012.2010.01276.x

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

27-30

eissn

0902-0063

issn

1399-0012

pii

CTR1276

journal_volume

24 Suppl 22

pub_type

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