Variability in the reporting of renal function endpoints in immunosuppression trials in renal transplantation: time for consensus?

abstract：INTRODUCTION:Atherosclerosis is a serious complication and leading cause of mortality in renal transplant recipients (RTRs). Hyperlipidemia may be associated with progression of renal disease and chronic allograft dysfunction. Similarities in the pathogenesis of glomerulosclerosis and atherosclerosis have been proposed...

journal_title：Clinical transplantation

authors： Kahraman S,Kiykim AA,Altun B,Gençtoy G,Arici M,Gulsun M,Erdem Y,Yasavul U,Turgan C,Cağlar S

更新日期：2004-06-01 00:00:00

abstract：:To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups ...

journal_title：Clinical transplantation

authors： Miles AM,Markell MS,Daskalakis P,Sumrani NB,Hong J,Sommer BG,Friedman EA

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:The goal of immunosuppressive therapy in heart transplantation is to maximize safety and efficacy while minimizing morbidity and mortality. We now have numerous drug combinations, but few have been compared with each other. AIM:To compare various immunosuppressive regimens assessing morbidity and mortality ...

journal_title：Clinical transplantation

authors： Aguero J,Almenar L,Martínez-Dolz L,Moro JA,Rueda J,Raso R,Chamorro C,Sanchez JM,Salvador A

更新日期：2008-01-01 00:00:00

abstract：:The concept of a narrow therapeutic window has guided the management of transplant recipients on cyclosporine immunosuppression since its inception more than a decade ago. The need to maintain immunosuppression and avoid toxicity imposed the requirement of monitoring cyclosporine levels within a limited range. The use...

journal_title：Clinical transplantation

authors： Takasugi M,Takasugi JK,Barba L

更新日期：1995-04-01 00:00:00

abstract：:The potential influence of racially or ethnically diverse cultural perspectives on patient compliance with post-transplant treatments is discussed. Domains of competency regarding culturally sensitive clinical practice are outlined to assist providers in better understanding the perspectives that may influence the vie...

journal_title：Clinical transplantation

authors： Prieto LR,Miller DS,Gayowski T,Marino IR

更新日期：1997-12-01 00:00:00

abstract：INTRODUCTION:Recurrence of hepatitis C virus (HCV) in hepatic allograft is a major concern after successful liver transplant (LTx). AIM:To examine the response rate to pegylated interferon (PEG-IFN) and ribavirin in post-LTx patients with HCV recurrence. PATIENTS AND METHODS:Between January 2003 and September 2006, 6...

journal_title：Clinical transplantation

authors： Jain A,Sharma R,Ryan C,Safadjou S,Kashyap R,Mantry P,Maliakkal B,Orloff M

更新日期：2010-01-01 00:00:00

abstract：:Donor lung allocation in the United States focuses on decreasing waitlist mortality and improving recipient outcomes. The implementation of allocation policy to match deceased donor lungs to waitlisted patients occurs through a unique partnership between government and private organizations, namely the Organ Procureme...

journal_title：Clinical transplantation

authors： Tsuang WM,Snyder LD,Budev MM

更新日期：2020-07-01 00:00:00

abstract：:These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice provide recommendations for the diagnosis and management of Candida infections in solid organ transplant recipients. Candida infections manifest primarily as candidemia and invasive candidiasis and cause con...

journal_title：Clinical transplantation

authors： Aslam S,Rotstein C,AST Infectious Disease Community of Practice.

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The survival of patients returning to hemodialysis (HD) following kidney transplant failure is unfavorable. However, the factors responsible for this poor outcome are largely unknown; chronic inflammation due to failed allograft and malnutrition may contribute to morbidity and mortality. We aimed to compare ...

journal_title：Clinical transplantation

authors： Yelken BM,Gorgulu N,Caliskan Y,Yazici H,Turkmen A,Yildiz A,Sever MS

更新日期：2010-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is highly prevalent in renal transplant candidates; however, its effect on the transplant outcome is still controversial. The aim of the present study was to determine the effect of HCV infection in the outcome of kidney transplantation in a single transplant center. The study populat...

journal_title：Clinical transplantation

authors： Arango J,Arbelaez M,Henao J,Mejia G,Arroyave I,Carvajal J,Garcia A,Gutierrez J,Velásquez A,Garcia L,Aguirre C

更新日期：2008-01-01 00:00:00

abstract：:In German legislation and in Eurotransplant's practice of liver allocation, urgency of need is considered as the primary distribution criterion. However, at a certain stage, the "sickest-first" principle is regarded as counterproductive as the performance status of these patients receiving an organ is on average criti...

journal_title：Clinical transplantation

authors： Bobbert M,Ganten TM

更新日期：2013-07-01 00:00:00

abstract：:Steroid-resistant acute rejection (SR-AR) and ductopenic rejection (DR) after liver transplantation are infrequent, but difficult to manage. We performed a retrospective review of patients with SR-AR or DR treated with sirolimus-based therapy. Since 2002, we have treated five patients with SR-AR and eight patients wit...

journal_title：Clinical transplantation

authors： Lladó L,Fabregat J,Castellote J,Ramos E,Torras J,Serrano T,Figueras J,Rafecas A

更新日期：2009-01-01 00:00:00

abstract：:An exploratory, post hoc analysis was performed using data from a prospective, multicenter, open-label, randomized, two-period (14 d per period), two-sequence, crossover, steady-state pharmacokinetic study comparing generic tacrolimus (Sandoz) vs. reference tacrolimus in stable renal transplant patients receiving thei...

journal_title：Clinical transplantation

authors： Bloom RD,Trofe-Clark J,Wiland A,Alloway RR

更新日期：2013-11-01 00:00:00

abstract：:We examined the UNOS database from 7/15/00-7/17/05 for Regional deceased donor liver utilization. For each region, we performed logistic regression and derived odds ratios (OR) for donor characteristics associated with livers being transplanted outside of the region or not transplanted at all. Regions with smallest an...

journal_title：Clinical transplantation

authors： Hayashi PH,Axelrod DA,Galanko J,Salvalaggio PR,Schnitzler M

更新日期：2011-01-01 00:00:00

abstract：:We sought to determine the incidence, risk factors, and consequences of acute rejection (AR) after conversion from a calcineurin inhibitor (CNI) to a proliferation signal inhibitor (PSI) in maintenance heart transplantation. Relevant clinical data were retrospectively obtained for 284 long-term heart transplant recipi...

journal_title：Clinical transplantation

authors： González-Vílchez F,Vázquez de Prada JA,Paniagua MJ,Almenar L,Mirabet S,Gómez-Bueno M,Díaz-Molina B,Arizón JM,Delgado J,Pérez-Villa F,Crespo-Leiro MG,Martínez-Dolz L,Roig E,Segovia J,Lambert JL,Lopez-Granados A,Escribano P

更新日期：2013-11-01 00:00:00

abstract：:Although patients within a transplant program are awaiting or have received disease modifying or curative treatment, they are also facing advanced illness and the possibility of death. The involvement of specialized palliative care services for these patients may improve symptom management and facilitate advance care ...

journal_title：Clinical transplantation

authors： Wentlandt K,Dall'Osto A,Freeman N,Le LW,Kaya E,Ross H,Singer LG,Abbey S,Clarke H,Zimmermann C

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate the characteristics of lung transplant recipients requiring additional pleural drainage catheters early post-lung transplantation and to determine the safety and efficacy of intrapleural fibrinolytics in these patients. METHODS:A retrospective review of lung transplant recipi...

journal_title：Clinical transplantation

authors： Kao CC,Cuevas JF,Tuthill S,Parulekar AD

更新日期：2019-06-01 00:00:00

abstract：:Pancreas retransplantation has become more frequent and represents a technical challenge for surgeons. Knowledge of alternative surgical options could be useful in difficult cases. We present a case of brutal diabetes mellitus in a patient with severe vascular disease that underwent a third pancreas transplant. Diffic...

journal_title：Clinical transplantation

authors： Garcia-Roca R,Humar A,Sturdevant M,Kobayashi T,Dunn T,Kandaswamy R,Sutherland D

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) and tacrolimus (Tac) in heart transplantation (HTx) have been compared but with certain drawbacks. We compared both drugs in a prospective analysis with medium-term follow-up. METHODS:Hundred and six patients were randomized to receive CsA or Tac (53 per group). Target levels of CsA were ...

journal_title：Clinical transplantation

authors： Sánchez-Lázaro IJ,Almenar L,Martínez-Dolz L,Buendía-Fuentes F,Agüero J,Navarro-Manchón J,Vicente JL,Salvador A

更新日期：2011-07-01 00:00:00

abstract：:We report an adult liver transplant recipient with parvovirus B19 infection, presenting as chronic transfusion-dependent anemia ensuing 1 month post-transplantation. Both serum and bone marrow cells were positive for parvovirus B19 DNA detected by polymerase chain reaction. The bone marrow biopsy revealed erythroid hy...

journal_title：Clinical transplantation

authors： Chang FY,Singh N,Gayowski T,Marino IR

更新日期：1996-06-01 00:00:00

abstract：:Differentiating acute pyelonephritis (APN) from acute rejection (AR) in renal allograft biopsies can sometimes be difficult because of overlapping clinical and histologic features, lack of positive urine cultures,and variable response to antibiotics. We wanted to study differential gene expression between AR and APN u...

journal_title：Clinical transplantation

authors： Oghumu S,Nori U,Bracewell A,Zhang J,Bott C,Nadasdy GM,Brodsky SV,Pelletier R,Satoskar AR,Nadasdy T,Satoskar AA

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Our objective is to evaluate whether hyperglycemia in the first 48 h after renal transplantation is independently associated with rejection, post-operative infection and post-transplant diabetes mellitus (PTDM) in a retrospective cohort study. METHODS:Patients who received a renal transplant in our hospital...

journal_title：Clinical transplantation

authors： van den Berg TJ,Bogers H,Vriesendorp TM,Surachno JS,DeVries JH,ten Berge IJ,Hoekstra JB

更新日期：2009-03-01 00:00:00

abstract：:Flow cytometric assay (FCA) was used to detect a cytomegalovirus (CMV) specific antigen (pp65) in CMV-infected fibroblast cells and in leukocytes of kidney recipients. FCA distinguished clearly between the infected and non-infected fibroblast cells. Regarding transplant patients, the FCA was positive when the number o...

journal_title：Clinical transplantation

authors： Essa S,Pacsa AS,Al-Attiyah R,El-Shazly A,Raghupathy R,Said T

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Liver ischaemia-reperfusion (I/R) occurs during resuscitation from haemorrhagic shock, hepatic transplantation and anatomic resection of the liver. This injury is associated with hepatocellular enzyme release and hepatocyte necrosis. The impact of chronic illnesses such as diabetes mellitus (DM) on hepatic I...

journal_title：Clinical transplantation

authors： Rogers H 3rd,Zibari GB,Roberts J,Turnage R,Lefer DJ

更新日期：2004-01-01 00:00:00

abstract：:The case of patient with glioblastoma metastatic to the peritoneal cavity 9 months after ventriculoperitoneal shunt surgery precluding cadaver organ procurement is presented. Even though central nervous tumors rarely metastasize spontaneously, the literature indicates that systemic metastases are related to previous s...

journal_title：Clinical transplantation

authors： Fecteau AH,Penn I,Hanto DW

更新日期：1998-08-01 00:00:00

abstract：:Use of C(2) monitoring for cyclosporine A (CsA) microemulsion results in improved clinical outcomes vs. trough (C(0)) monitoring. Logistical issues include accurate timing of the C(2) sample; requirement for sample dilution with most standard assay techniques; and inconvenience for patients. Recently, it has been show...

journal_title：Clinical transplantation

authors： Yonan N,Martyszczuk R,Machaal A,Baynes A,Keevil BG

更新日期：2006-03-01 00:00:00

abstract：:Recent changes in Center for Medicare & Medicaid Services (CMS) condition for participation, using benchmark volume/outcomes requirements for certification, have been implemented. Consequently, the ability of a transplant center to assess its risk tolerance is important in successful management. An analysis of SRTR da...

journal_title：Clinical transplantation

authors： Johnson SR,Karp SJ,Curry MP,Barugel M,Rodrigue JR,Mandelbrot DA,Rogers CP,Hanto DW

更新日期：2012-05-01 00:00:00

abstract：:The long-term side effects of lifelong steroid immunosuppression are well documented, therefore, steroid withdrawal (SW) if safe would clearly be of benefit. From 1987-1996, 470 kidney transplants were performed at our institution. During this time period, steroid withdrawal was offered to a select group of patients (...

journal_title：Clinical transplantation

authors： Sanfey H,Haussman G,Isaacs I,Ishitani M,Lobo P,McCullough C,Pruett T

更新日期：1997-10-01 00:00:00

abstract：:As fertility can be restored to normal soon after a kidney transplant, it is important for physicians caring for recipients to be able to inform the patient about the potential risks of pregnancy. Current opinion is that pregnancy can be successful if carried out under optimal circumstances, including stable allograft...

journal_title：Clinical transplantation

authors： Concepcion BP,Schaefer HM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Lung perfusions after single lung transplantation (SLT) have not been fully clarified in patients with interstitial lung disease (ILD). The present study aimed to investigate temporal changes in native lung perfusion and their associated clinical factors in patients with ILD who have undergone SLT. METHODS:...

journal_title：Clinical transplantation

authors： Sokai A,Handa T,Chen F,Tanizawa K,Aoyama A,Kubo T,Ikezoe K,Nakatsuka Y,Oguma T,Hirai T,Nagai S,Chin K,Date H,Mishima M

更新日期：2016-04-01 00:00:00