No apparent impact of increased post-operative blood glucose levels on clinical outcome in kidney transplant recipients.

Abstract:

BACKGROUND:Our objective is to evaluate whether hyperglycemia in the first 48 h after renal transplantation is independently associated with rejection, post-operative infection and post-transplant diabetes mellitus (PTDM) in a retrospective cohort study. METHODS:Patients who received a renal transplant in our hospital in 2003 or 2004 were included. Glucose values until 48 h after surgery were retrieved from laboratory reports. Biopsy proven acute rejection, culture proven infections and PTDM were scored until four months after transplantation. Data were analyzed using univariate analysis and logistic multivariate analysis. RESULTS:At least one post-operative glucose value could be retrieved for 150/151 patients. Rejection occurred in 46/150 (30.5%), infection in 47/150 (31.1%) and PTDM in 19/150 (12.6%) patients. When corrected for other risk factors, no relation was found between post-operative glucose levels and rejection (weak inverse relation, OR = 0.82; 95% CI = 0.65-1.03; p = 0.09), post-operative glucose and infections (OR = 0.98; 95% CI = 0.80-1.21; p = 0.84) and post-operative glucose and PTDM (OR = 0.93; 95% CI = 0.70-1.23; p = 0.63). CONCLUSION:Increased post-operative blood glucose levels after renal transplantation were not found to be a risk factor for graft rejection. Also, post-operative glucose levels were not found to be associated with PTDM and post-operative infections.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

van den Berg TJ,Bogers H,Vriesendorp TM,Surachno JS,DeVries JH,ten Berge IJ,Hoekstra JB

doi

10.1111/j.1399-0012.2008.00910.x

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

256-63

issue

2

eissn

0902-0063

issn

1399-0012

journal_volume

23

pub_type

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