Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick sampling.

Abstract:

:Use of C(2) monitoring for cyclosporine A (CsA) microemulsion results in improved clinical outcomes vs. trough (C(0)) monitoring. Logistical issues include accurate timing of the C(2) sample; requirement for sample dilution with most standard assay techniques; and inconvenience for patients. Recently, it has been shown that CsA concentrations in capillary blood correlate closely with levels in venepuncture samples, and that liquid chromatography tandem mass spectrometry (LC-MS/MS) can analyse CsA concentration using undiluted capillary blood from fingerprick samples. In a study to assess the feasibility of CsA monitoring, 52 stable heart transplant patients were provided with kits to take fingerprick trough and C(2) blood samples at home, returning them to the laboratory by post for LC-MS/MS analysis. In total, 225 samples were provided, of which 14 (6%) were unsuitable for analysis because of clotting (n = 10) or insufficient volume (n = 4). Discomfort was not a problem and initial difficulties that some patients reported in taking the samples resolved with experience. All samples were returned by the postal system in a timely manner. Use of fingerprick assays could allow transplant physicians to have access to C(2) levels when patients visit the clinic for review, and avoids the need for patients to attend the clinic or local healthcare centre solely for venepuncture. A barrier to more widespread introduction of fingerprick testing is likely to be lack of suitable MS facilities and trained personnel. In conclusion, self-administered fingerprick testing for CsA blood levels is practical to implement and highly convenient for patients and offers advantages for the transplant team.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Yonan N,Martyszczuk R,Machaal A,Baynes A,Keevil BG

doi

10.1111/j.1399-0012.2005.00472.x

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

221-5

issue

2

eissn

0902-0063

issn

1399-0012

pii

CTR472

journal_volume

20

pub_type

杂志文章
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  • Immunization by blood-type antigen in human immunoglobulin products before ABO-incompatible kidney transplantation.

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    authors: Sawada T,Ando T,Sato S,Kubota K,Fuchinoue S,Teraoka S

    更新日期:2004-04-01 00:00:00

  • Regional differences in deceased donor liver transplantation and their implications for organ utilization and allocation.

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    更新日期:2011-01-01 00:00:00

  • The feared five fungal infections in kidney transplant recipients: A single-center 20-year experience.

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    更新日期:2018-07-01 00:00:00

  • Effect of Hepatitis C donor status on heart transplantation outcomes in the United States.

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    pub_type: 杂志文章

    doi:10.1111/ctr.14220

    authors: Doulamis IP,Tzani A,Moustakidis S,Kampaktsis PN,Briasoulis A

    更新日期:2021-01-08 00:00:00

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13360

    authors: Issa N,Sánchez OA,Kukla A,Riad SM,Berglund DM,Ibrahim HN,Matas AJ

    更新日期:2018-09-01 00:00:00

  • Renal allograft loss due to proximal extension of ileofemoral deep venous thrombosis.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02006.x

    authors: Ramirez PJ,Gohh RY,Kestin A,Monaco AP,Morrissey PE

    更新日期:2002-08-01 00:00:00

  • Psychosocial outcome of living donors after living donor liver transplantation: a pilot study.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02002.x

    authors: Walter M,Bronner E,Pascher A,Steinmüller T,Neuhaus P,Klapp BF,Danzer G

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    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

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    更新日期:2009-11-01 00:00:00

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    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

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  • Echinocandin use in lung transplant recipients.

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    pub_type: 临床试验,杂志文章

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    更新日期:2018-12-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    更新日期:2012-07-01 00:00:00

  • The pathogenesis of xenograft rejection.

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    pub_type: 杂志文章,评审

    doi:

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  • Interleukin 6 at reperfusion: A potent predictor of hepatic and extrahepatic early complications after liver transplantation.

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    pub_type: 杂志文章

    doi:10.1111/ctr.13357

    authors: Faitot F,Besch C,Lebas B,Addeo P,Ellero B,Woehl-Jaegle ML,Namer IJ,Bachellier P,Freys G

    更新日期:2018-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.16.s7.3.x

    authors: Gebel HM,Harris SB,Zibari G,Bray RA

    更新日期:2002-01-01 00:00:00

  • Heparin infusion in simultaneous pancreas and kidney transplantation reduces graft thrombosis and improves graft survival.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12780

    authors: Aboalsamh G,Anderson P,Al-Abbassi A,McAlister V,Luke PP,Sener A

    更新日期:2016-09-01 00:00:00

  • Use of G-CSF-stimulated marrow in allogeneic hematopoietic stem cell transplantation settings: a comprehensive review.

    abstract::In recent years, several researchers have unraveled the previously unrecognized effects of granulocyte colony-stimulating factor (G-CSF) on hematopoiesis and the immune cell functions of bone marrow in healthy donors. In human leukocyte antigen-matched or haploidentical transplant settings, available data have establi...

    journal_title:Clinical transplantation

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    doi:10.1111/j.1399-0012.2010.01298.x

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  • Long-term clinicopathological impact of calcineurin inhibitor cessation without specific cytoreductive induction in kidney transplantation.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12274

    authors: Tanabe T,Morita K,Fujita H,Hatanaka K,Ogawa Y,Hirose T,Sasaki H,Iwami D,Hotta K,Nonomura K

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  • Liver transplantation in patients aged 65 and over: a case-control study.

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    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01230.x

    authors: Montalti R,Rompianesi G,Di Benedetto F,Ballarin R,Gerring RC,Busani S,De Pietri L,De Ruvo N,Iemmolo RM,Guerrini GP,Smerieri N,Gerunda GE

    更新日期:2010-09-01 00:00:00

  • BK polyomavirus in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

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    pub_type: 杂志文章

    doi:10.1111/ctr.13528

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Liver cell transplantation in children.

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    pub_type: 杂志文章

    doi:

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    更新日期:2000-10-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/ctr.12415

    authors: Ogawa E,Hori T,Doi H,Segawa H,Uemoto S

    更新日期:2014-09-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:

    authors: Chang FY,Singh N,Gayowski T,Marino IR

    更新日期:1996-06-01 00:00:00