Liver cell transplantation in children.

Abstract:

:With increasing shortage of donor organs and changes in organ allocation systems, there is a considerable need for alternative or supportive techniques in the field of liver transplantation. Liver cell transplantation (LCT) is such an innovative technique that is especially promising for use in children, because it is less invasive than orthotopic liver transplantation (OLT). Two main indications exist: acute liver failure (ALF) and hepatic-based inborn errors of metabolism. Ten children with ALF underwent LCT so far. One patient recovered without OLT, five were successfully bridged to OLT, and four died. Clinical improvement like reduced hyperammonemia, improved coagulation, and regression of hepatic encephalopathy occurred in the majority of patients. For the treatment of inborn errors of metabolism, experience exists with Crigler-Najjar syndrome type 1 (CNS 1, n = 5) and urea cycle disorders (UCD, n = 6). All but two patients experienced metabolic stabilization for a mean period of 9.7 months, before the majority of children underwent OLT. Whereas transplant success in CNS 1 patients can be easily monitored by plasma bilirubin levels, it is much more difficult in UCDs, where many factors can contribute to clinical deterioration. Nevertheless, these individual therapeutic attempts of LCT yielded encouraging results, and prospective studies should be initiated.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Meyburg J,Schmidt J,Hoffmann GF

doi

10.1111/j.1399-0012.2009.01113.x

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

75-82

eissn

0902-0063

issn

1399-0012

pii

CTR1113

journal_volume

23 Suppl 21

pub_type

杂志文章,评审
  • Transplantation of a severely lacerated liver--a case report with review of the literature.

    abstract::Using lacerated livers for liver transplantation (LTx) can add an option to the extended donor criteria. We present an LTx case using a severely lacerated liver and review of the literature for reported cases. We used a high-grade lacerated liver from a 19-yr-old brain-dead patient caused by traffic accident. The live...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2008.00914.x

    authors: Mehrabi A,Fonouni H,Ahmadi R,Schmied BM,Müller SA,Welsch T,Hallscheidt P,Zeier M,Weitz J,Schmidt J

    更新日期:2009-06-01 00:00:00

  • Optimal timing for living-related liver transplantation in children.

    abstract:BACKGROUND:The pediatric end stage liver disease (PELD) score has been used widely to prioritize children awaiting cadaveric liver transplantation (LTx). To establish the objective parameter for optimal timing of living-related LTx (LRLTx), we have assessed our cases using the PELD score. METHODS:From 1997 to 2002, 24...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00194.x

    authors: Kimura T,Hasegawa T,Sasaki T,Shimizu Y,Mushiake S,Fukuzawa M,Okada A

    更新日期:2004-10-01 00:00:00

  • Calcification score evaluation in patients listed for renal transplantation.

    abstract::Based on native CT scans of the pelvic region using a standardized calcification score, evaluation of iliac vascular calcification was performed between 2008 and 2012 prior to listing for renal transplantation in 205 patients with chronic kidney disease. Vascular calcification showed a decrease from proximal to distal...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12888

    authors: Kahn J,Ram LM,Eberhard K,Groselj-Strele A,Obermayer-Pietsch B,Müller H

    更新日期:2017-03-01 00:00:00

  • Histological factors of 1-h biopsy influencing the delayed renal function and outcome in cadaveric renal allografts.

    abstract::The morphological characteristics of a kidney biopsy specimen taken 1 h after reperfusion of blood into the graft (1-h biopsy) during a cadaveric transplant operation were studied. The aim of the 1-h biopsy is to evaluate the pre-transplant risk factors for the delayed graft function, assess the renal function of the ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Oda A,Morozumi K,Uchida K

    更新日期:1999-01-01 00:00:00

  • Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick sampling.

    abstract::Use of C(2) monitoring for cyclosporine A (CsA) microemulsion results in improved clinical outcomes vs. trough (C(0)) monitoring. Logistical issues include accurate timing of the C(2) sample; requirement for sample dilution with most standard assay techniques; and inconvenience for patients. Recently, it has been show...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00472.x

    authors: Yonan N,Martyszczuk R,Machaal A,Baynes A,Keevil BG

    更新日期:2006-03-01 00:00:00

  • Conundrums with FlowPRA beads.

    abstract::In 1969, a study by Patel and Terasaki persuaded the renal transplant community that a pre-transplant cross-match should always be performed between donor and recipient to detect HLA antibodies and prevent hyperacute allograft rejection. Although the role of the cross-match among nonsensitized patients is controversia...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.16.s7.3.x

    authors: Gebel HM,Harris SB,Zibari G,Bray RA

    更新日期:2002-01-01 00:00:00

  • Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines.

    abstract::Endothelium-dependent vasodilation in the peripheral circulation may be impaired in heart transplant recipients (HTx rec). Conflicting results have been obtained and the mechanisms involved have not been examined. In the present study, we examined whether long-time survivors of heart transplantation (Tx) show signs of...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140307.x

    authors: Holm T,Aukrust P,Andreassen AK,Ueland T,Brosstad F,Frøland SS,Simonsen S,Gullestad L

    更新日期:2000-06-01 00:00:00

  • A prospective randomized study comparing cyclosporine versus tacrolimus combined with daclizumab, mycophenolate mofetil, and steroids in heart transplantation.

    abstract:BACKGROUND:Cyclosporine (CsA) and tacrolimus (Tac) in heart transplantation (HTx) have been compared but with certain drawbacks. We compared both drugs in a prospective analysis with medium-term follow-up. METHODS:Hundred and six patients were randomized to receive CsA or Tac (53 per group). Target levels of CsA were ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2010.01309.x

    authors: Sánchez-Lázaro IJ,Almenar L,Martínez-Dolz L,Buendía-Fuentes F,Agüero J,Navarro-Manchón J,Vicente JL,Salvador A

    更新日期:2011-07-01 00:00:00

  • T-cell flow-cytometry crossmatch and long-term renal graft survival.

    abstract::Flow cytometry crossmatch (FCXM) is a more sensitive technique than classical complement-dependent cytotoxicity (CDC) for the detection of donor-directed antibody before renal transplantation. Nevertheless, the role of FCXM in predicting long-term survival of kidney grafts is still unclear. The purpose of our study wa...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00226.x

    authors: Rebibou JM,Bittencourt MC,Saint-Hillier Y,Chabod J,Dupont I,Bittard H,Chalopin JM,Hervé P,Tiberghien P

    更新日期:2004-10-01 00:00:00

  • A prospective 3-yr evaluation of tacrolimus-based immunosuppressive therapy in immunological high risk renal allograft recipients.

    abstract:BACKGROUND:There have been no published data on use of the the newer immunosuppressants tacrolimus and mycophenolate mofetil (MMF) in high immunological risk renal transplantation. We therefore undertook a prospective study to systematically assess outcomes using these agents as part of an aggressive immunosuppressive ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1399-0012.2005.00275.x

    authors: Zaltzman JS,Boucher A,Busque S,Halloran PF,Landsberg DN,McAlister VC,Russell D,Shoker A,Shapiro J,Tchervenkov JI,Ferguson R

    更新日期:2005-02-01 00:00:00

  • Effect of Hepatitis C donor status on heart transplantation outcomes in the United States.

    abstract:BACKGROUND:Recent studies demonstrated safety and efficacy of heart transplantation (HT) from hepatitis C virus (HCV)-positive donors. We sought to evaluate the impact of HCV donor status on the outcomes of patients undergoing HT in the United States. METHODS:We analyzed a retrospective cohort of adult patients from t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14220

    authors: Doulamis IP,Tzani A,Moustakidis S,Kampaktsis PN,Briasoulis A

    更新日期:2021-01-08 00:00:00

  • Cervical human papillomavirus infection in the early postoperative period after liver transplantation: Prevalence, risk factors, and concordance with anal infections.

    abstract::Solid organ transplant recipients are at increased risk of developing several human papillomavirus (HPV)-related malignancies, including cervical and anal cancers. The purpose of this prospective study was to assess the initial prevalence and risk factors for high-risk HPV (HR-HPV) cervical infections in liver transpl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12894

    authors: Grąt K,Grąt M,Wronka KM,Pietrzak B,Suchońska B,Walter de Walthoffen S,Młynarczyk G,Krawczyk M,Wielgoś M

    更新日期:2017-03-01 00:00:00

  • Influence of immunosuppressive regimens on short-term morbidity and mortality in heart transplantation.

    abstract:BACKGROUND:The goal of immunosuppressive therapy in heart transplantation is to maximize safety and efficacy while minimizing morbidity and mortality. We now have numerous drug combinations, but few have been compared with each other. AIM:To compare various immunosuppressive regimens assessing morbidity and mortality ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00751.x

    authors: Aguero J,Almenar L,Martínez-Dolz L,Moro JA,Rueda J,Raso R,Chamorro C,Sanchez JM,Salvador A

    更新日期:2008-01-01 00:00:00

  • Idiopathic interstitial pneumonia following stem cell transplantation.

    abstract::Idiopathic interstitial pneumonia (IIP) can occur after stem cell transplantation, but the aetiology is unknown. Based on the association between angiitis syndrome and Helicobacter pylori infection, we identified possible risk factors common to these two conditions. Among 83 patients who underwent stem cell transplant...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.00053.x

    authors: Yamaguchi N,Takatsuka H,Wakae T,Okada M,Fujimori Y,Okamoto T,Kakishita E,Hara H

    更新日期:2003-08-01 00:00:00

  • Outcomes at 7 years post-transplant in black vs nonblack kidney transplant recipients administered belatacept or cyclosporine in BENEFIT and BENEFIT-EXT.

    abstract::Clinical outcomes are generally worse for black vs nonblack renal allograft recipients. In BENEFIT and BENEFIT-EXT, recipients were randomized to belatacept more intense-based, belatacept less intense-based, or cyclosporine-based immunosuppression. At year 7, belatacept was associated with superior graft survival vs c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/ctr.13225

    authors: Florman S,Vincenti F,Durrbach A,Abouljoud M,Bresnahan B,Garcia VD,Mulloy L,Rice K,Rostaing L,Zayas C,Calderon K,Meier-Kriesche U,Polinsky M,Yang L,Medina Pestana J,Larsen CP

    更新日期:2018-04-01 00:00:00

  • ALLOREACTIVE T LYMPHOCYTES CULTURED FROM LIVER TRANSPLANT BIOPSIES: ASSOCIATIONS OF HLA SPECIFICITY WITH CLINICOPATHOLOGICAL FINDINGS.

    abstract::Lymphocyte cultures grown from liver allograft biopsies were shown to exhibit alloreactivity towards donor cells as measured by primed lymphocyte testing (PLT). The PLT specificity was determined in assays using HLA typed panel cells and/or by inhibition testing with HLA specific monoclonal antibodies. Certain culture...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Markus BH,Demetris AJ,Saidman S,Fung JJ,Zeevi A,Starzl TE,Duquesnoy RJ

    更新日期:1988-01-01 00:00:00

  • Living-related liver transplantation in adult recipients: a hypothesis.

    abstract::Living-related liver transplantation (LRLT) in pediatric recipients has been successful with 90% 1-year survival (1, 2). LRLT in adults is yet to succeed. We hypothesize a management strategy based on the donor graft weight-to-recipient body weight ratio (GRBWR) and the Redox Tolerance Index (RTI) (3). Favorable recip...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Habib N,Tanaka K

    更新日期:1995-02-01 00:00:00

  • Validity of patient skin cancer report among organ transplant recipients.

    abstract::Skin cancer is a common, potentially life-threatening malignancy in organ transplant recipients (OTR), and it is important for transplant physicians to be aware of patient history of skin cancer. Patient self-report represents a quick method of obtaining past medical history of skin cancer but no study has validated t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01601.x

    authors: Dybbro E,Mihalis E,Hirose R,Arron ST

    更新日期:2012-03-01 00:00:00

  • Randomized trial of early corticosteroid reduction vs. regular-dose corticosteroid maintenance in combination with tacrolimus and mycophenolate mofetil in living donor kidney transplant recipients: the Brazilian CORRETA trial.

    abstract::This multicenter, randomized trial aimed to compare the safety and efficacy of an early reduction in corticosteroid dose vs. long-term maintenance in Brazilian patients on an immunosuppressive regimen based on tacrolimus and mycophenolate mofetil (MMF). In the control arm, prednisone was progressively reduced from day...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-0012.2009.01185.x

    authors: Garcia VD,Carvalho DB,Gonçalves RT,Cavalcanti RL,Campos HH,Abbud-Filho M,Lobao-Neto AA

    更新日期:2010-07-01 00:00:00

  • Attitudes and opinions on organ donation: an opportunity to educate in a Canadian city.

    abstract:BACKGROUND:Patients on organ transplant waiting lists continue to far exceed donor rates. We seek to understand the barriers preventing people in a Canadian city from donating organs for transplantation. METHODS:One thousand adults were surveyed assessing knowledge, personal involvement, and attitudes about organ dona...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01260.x

    authors: Lee E,Midodizi W,Gourishankar S

    更新日期:2010-11-01 00:00:00

  • Prednisone-free maintenance immunosuppression in obese kidney transplant recipients.

    abstract::Obese transplant recipients (BMI ≥ 30 kg/m2 ) have decreased posttransplant patient and graft survival compared with their nonobese counterparts. At the same time, many prednisone-related side effects (eg, new-onset diabetes) are similar to those associated with obesity. Using SRTR data, we studied outcomes associated...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13668

    authors: Matas AJ,Vock DM

    更新日期:2019-10-01 00:00:00

  • Aortoiliac surgery concomitant with kidney transplantation: a single center experience.

    abstract:INTRODUCTION:Aortoiliac pathology in kidney allograft recipients is not rare but treatment timing is controversial. As most publications on this topic are case reports its difficult to evaluate long-term outcomes of those clinical challenges. Herein we report long-term results of these procedures. METHODS:From 1970 to...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2009.00981.x

    authors: Tsivian M,Neri F,Nardo B,Bertelli R,Cavallari G,Fuga G,Faenza A

    更新日期:2009-03-01 00:00:00

  • Living-donor liver transplantation for congenital biliary atresia with porto-pulmonary hypertension and moderate or severe pulmonary arterial hypertension: Kyoto University experience.

    abstract::Porto-pulmonary hypertension with moderate or severe pulmonary arterial hypertension (PAH) is viewed as a contraindication to liver transplantation (LT) because of associated poor outcomes; however, patients with biliary atresia (BA) are generally good candidates for LT. Ten patients with moderate/severe PAH underwent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12415

    authors: Ogawa E,Hori T,Doi H,Segawa H,Uemoto S

    更新日期:2014-09-01 00:00:00

  • Low-dose basiliximab induction therapy in heart transplantation.

    abstract::We prospectively studied efficacy and safety outcomes of two 10-mg doses of intravenous basiliximab on day 0 and day 4 for induction therapy in 17 consecutive de novo heart transplant recipients. By the 2-week assessment post-transplant, there were no deaths, graft failures, or acute cellular rejections (ACRs) ISHLT g...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13132

    authors: Kittipibul V,Tantrachoti P,Ongcharit P,Ariyachaipanich A,Siwamogsatham S,Sritangsirikul S,Thammanatsakul K,Puwanant S

    更新日期:2017-12-01 00:00:00

  • Steroid withdrawal in pancreas transplant recipients.

    abstract:BACKGROUND:Numerous studies of steroid withdrawal have been carried out in kidney and liver transplant recipients, but only a few in pancreas transplant recipients. Yet, pancreas transplant recipients could have significant long-term benefits from steroid withdrawal. METHODS:We performed a retrospective analysis to de...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140114.x

    authors: Humar A,Parr E,Drangstveit MB,Kandaswamy R,Gruessner AC,Sutherland DE

    更新日期:2000-02-01 00:00:00

  • Post-transplant lymphoproliferative disease in lung transplantation: A nested case-control study.

    abstract::Post-transplant lymphoproliferative disorder (PTLD) may compromise long-term outcome of lung transplant (LTx) recipients. A case-control study was performed, comparing LTx recipients with PTLD (n=31) to matched recipients without PTLD (Controls, n=62). Risk factors for PTLD and post-transplant outcomes were assessed. ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12983

    authors: Leyssens A,Dierickx D,Verbeken EK,Tousseyn T,Verleden SE,Vanaudenaerde BM,Dupont LJ,Yserbyt J,Verleden GM,Van Raemdonck DE,Vos R

    更新日期:2017-07-01 00:00:00

  • Laparoscopic donor nephrectomy - safety in a small-volume transplant center.

    abstract:INTRODUCTION:Laparoscopy is a standard surgical option for live donor nephrectomy (LDN) at the majority of transplant centers. Equivalent graft survival with shorter convalescence has been reported by several large volume centers. With the arrival of an experienced laparoscopic surgeon in 2002, we began to offer laparo...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01153.x

    authors: Riley J,Troxel S,Wakefield M,Ross G,Weinstein S

    更新日期:2010-05-01 00:00:00

  • Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients: Guidelines from the American Society of Transplantation Community of Practice.

    abstract::These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice address the prevention and management of Clostridium difficile infection in solid organ transplant (SOT) recipients. Clostridioides (formerly Clostridium) difficile infection (CDI) is among the most common h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13564

    authors: Mullane KM,Dubberke ER,AST ID Community of Practice.

    更新日期:2019-09-01 00:00:00

  • Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature.

    abstract::Granulomatous interstitial nephritis (GIN) is a rare histologic diagnosis in renal allografts. We report three cases with GIN. Case 1: a 37-yr-old woman received a kidney from her mother. On follow-up 15 months later, serum creatinine was increased and a graft biopsy showed epithelioid granuloma in the center of massi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2012.01643.x

    authors: Hotta K,Fukasawa Y,Sasaki H,Seki T,Togashi M,Harada H

    更新日期:2012-07-01 00:00:00

  • The effect of sirolimus on sex hormone levels of male renal transplant recipients.

    abstract:BACKGROUND:It is unclear whether sirolimus, a newer immunosuppressive agent, widely used in renal transplantation, affects male sex hormone levels or sexual function. METHODS:Sex hormone profiles in male renal transplant recipients were obtained and compared between a sirolimus-treated group and a group not on sirolim...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00257.x

    authors: Lee S,Coco M,Greenstein SM,Schechner RS,Tellis VA,Glicklich DG

    更新日期:2005-04-01 00:00:00