Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines.

Abstract:

:Endothelium-dependent vasodilation in the peripheral circulation may be impaired in heart transplant recipients (HTx rec). Conflicting results have been obtained and the mechanisms involved have not been examined. In the present study, we examined whether long-time survivors of heart transplantation (Tx) show signs of endothelial dysfunction in the peripheral microcirculation, and further investigated the possible role of endothelium-related markers and proinflammatory cytokines in this process. The vasodilatory responses to acetylcholine (Ach) (endothelium-dependent) and sodium nitroprusside (SNP) (endothelium-independent) were evaluated by skin laser-Doppler perfusion measurements in 63 clinically stable HTx rec 6 yr (range 1-13 yr) after Tx, and compared with 20 healthy controls. Ten HTx rec were also followed prospectively with three repeated measurements during the first year after Tx. Plasma von Willebrand factor, big-endothelin (b-ET), and proinflammatory cytokines were measured by enzyme immunoassays. Vascular responses to both Ach and SNP were significantly attenuated in the HTx rec compared with controls. In longitudinal testing, there was a significant reduction in endothelium-dependent vasodilation, but not independent vasodilation from 1 to 12 months after Tx. Plasma levels of vWF and b-ET, as well as levels of proinflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, were all markedly increased in HTx rec. HTx rec responses to Ach were negatively correlated to TNF-alpha levels in plasma (r = -0.39, p < 0.01). Moreover, there was also a significant positive correlation between plasma b-ET and TNF-alpha (r = 0.34, p < 0.01). In the long-term follow-up of HTx rec, endothelial dysfunction is demonstrated by both regulation of blood flow in the skin microcirculation and by raised markers of endothelial activation in plasma. This endothelial dysfunction may be related to enhanced levels of proinflammatory cytokines in these patients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Holm T,Aukrust P,Andreassen AK,Ueland T,Brosstad F,Frøland SS,Simonsen S,Gullestad L

doi

10.1034/j.1399-0012.2000.140307.x

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

218-25

issue

3

eissn

0902-0063

issn

1399-0012

journal_volume

14

pub_type

杂志文章
  • Steroid-related complications in the cyclosporine era.

    abstract::Steroid withdrawal has potential risks (rejection) and benefits (fewer complications). Most data on steroid-related complications predates cyclosporine (CsA). We tabulated the incidence of posttransplant complications considered to be steroid-related in 748 adult kidney transplant recipients (with at least 1 year of f...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Fryer JP,Granger DK,Leventhal JR,Gillingham K,Najarian JS,Matas AJ

    更新日期:1994-06-01 00:00:00

  • Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation.

    abstract:BACKGROUND:One severe side effect of calcineurin inhibitors (CNIs: such as cyclosporine [CsA] and tacrolimus [FK506]) is neurotoxicity. CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp), encoded by ABCB1 gene. In the present study, we hypothesized that genetic variability in CYP3A5 and ABCB1 genes may be associa...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01181.x

    authors: Yanagimachi M,Naruto T,Tanoshima R,Kato H,Yokosuka T,Kajiwara R,Fujii H,Tanaka F,Goto H,Yagihashi T,Kosaki K,Yokota S

    更新日期:2010-11-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00

  • Comparison of histopathological characteristics of allograft biopsy between responder and non-responder to antiproteinuric effect of angiotensin-converting enzyme inhibitor (ACEI).

    abstract::Angiotensin-converting enzyme inhibitor (ACEI) has become recognized as agents that have renoprotective effects in the treatment of progressive renal diseases including post-transplant kidneys. Previously we demonstrated the safety and effectiveness of ACEI treatment on the hypertensive proteinuric post-transplant pat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00244.x

    authors: Namba Y,Moriyama T,Kyo M,Oka K,Kokado Y,Shi Y,Imamura R,Ichimaru N,Okuyama A,Takahara S

    更新日期:2004-01-01 00:00:00

  • Development of the living donation and kidney transplantation information made easy (KidneyTIME) educational animations.

    abstract:BACKGROUND:Current web-based educational approaches about living kidney donation (LKD) are complex, lengthy, and/or text-laden, which may impair accurate interpretation of information, thereby limiting kidney transplant access. PURPOSE:This paper describes the process of developing animation-based LKD education design...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13830

    authors: Kayler LK,Dolph B,Seibert R,Keller M,Cadzow R,Feeley TH

    更新日期:2020-04-01 00:00:00

  • Correlation between myocardial fibrosis and restrictive cardiac physiology in patients undergoing retransplantation.

    abstract::After cardiac transplant, there is often development of restrictive cardiac physiology. Little is known about the factors that contribute to this physiology and its correlation with pathology. Heart retransplantation provides a valuable opportunity to further understand this relationship. In this study, we investigate...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.12250

    authors: Kobashigawa JA,Itagaki BK,Razi RR,Patel JK,Chai W,Kawano MA,Goldstein Z,Kittleson MM,Fishbein MC

    更新日期:2013-11-01 00:00:00

  • Living-donor liver transplantation for congenital biliary atresia with porto-pulmonary hypertension and moderate or severe pulmonary arterial hypertension: Kyoto University experience.

    abstract::Porto-pulmonary hypertension with moderate or severe pulmonary arterial hypertension (PAH) is viewed as a contraindication to liver transplantation (LT) because of associated poor outcomes; however, patients with biliary atresia (BA) are generally good candidates for LT. Ten patients with moderate/severe PAH underwent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12415

    authors: Ogawa E,Hori T,Doi H,Segawa H,Uemoto S

    更新日期:2014-09-01 00:00:00

  • Molecular assessment of antibody-mediated rejection in human pancreas allograft biopsies.

    abstract::Pancreas transplant longevity is limited by immune rejection, which is diagnosed by graft biopsy using the Banff Classification. The histological criteria for antibody-mediated rejection (AMR) are poorly reproducible and inconsistently associated with outcome. We hypothesized that a 34-gene set associated with antibod...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14065

    authors: Roufosse C,Drachenberg C,Renaudin K,Willicombe M,Toulza F,Dominy K,McLean A,Simmonds N,de Kort H,Cantarovitch D,Scalea J,Mengel M,Adam B

    更新日期:2020-11-01 00:00:00

  • Liver transplant center risk tolerance.

    abstract::Recent changes in Center for Medicare & Medicaid Services (CMS) condition for participation, using benchmark volume/outcomes requirements for certification, have been implemented. Consequently, the ability of a transplant center to assess its risk tolerance is important in successful management. An analysis of SRTR da...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01658.x

    authors: Johnson SR,Karp SJ,Curry MP,Barugel M,Rodrigue JR,Mandelbrot DA,Rogers CP,Hanto DW

    更新日期:2012-05-01 00:00:00

  • The impact of pancreas transplantation on patient employment opportunities.

    abstract:BACKGROUND:A questionnaire study was designed to determine whether the quality of life benefit provided by receiving a kidney-pancreas (KP) transplant increased the incentive to return to work, compared with patients receiving a kidney alone (KA) transplant. METHODS:A confidential questionnaire was sent to 58 patients...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00115.x

    authors: Knight RJ,Daly L

    更新日期:2004-02-01 00:00:00

  • Reduced dose Thymoglobulin, tacrolimus, and mofetil mycophenolate results in excellent solitary pancreas transplantation outcomes.

    abstract:BACKGROUND:Graft survival following solitary pancreas transplantation has traditionally lagged behind that of simultaneous pancreas-kidney transplants. Thymoglobulin (TMG), a polyclonal rabbit-derived antilymphocyte antibody was originally introduced as treatment for acute rejection of renal allografts. However, data r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02031.x

    authors: Tan M,Cantarovich M,Mangel R,Paraskevas S,Fortier M,Metrakos P

    更新日期:2002-12-01 00:00:00

  • Attitudes of commercial renal transplant recipients toward renal transplantation in India.

    abstract::Renal transplantation offers patients with end-stage renal disease the best opportunity for rehabilitation and long-term survival. However, there is a critical shortage of transplantable kidneys worldwide. This plays well into the hands of transplanters and entrepreneurs involved in commercial renal transplantation, p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Qunibi W,Abulrub D,Shaheen F,el-Din AB,Alfurayh O,Almeshari K

    更新日期:1995-08-01 00:00:00

  • Risk factors for acute renal failure requiring dialysis after liver transplantation.

    abstract::Acute renal failure (ARF) is a common and severe complication after liver transplantation (LT). The aim of this study was to ascertain the impact of ARF requiring dialysis in the outcome of LT and to analyze the risk factors leading to this event in the early post-operative period. From October 1988 to December 1994, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Bilbao I,Charco R,Balsells J,Lazaro JL,Hidalgo E,Llopart L,Murio E,Margarit C

    更新日期:1998-04-01 00:00:00

  • Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension.

    abstract::In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of po...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13360

    authors: Issa N,Sánchez OA,Kukla A,Riad SM,Berglund DM,Ibrahim HN,Matas AJ

    更新日期:2018-09-01 00:00:00

  • A high antithymocyte globulin dose increases the risk of relapse after reduced intensity conditioning HSCT with unrelated donors.

    abstract::The study included 110 consecutive patients with hematological malignancies receiving fludarabine-based reduced intensity conditioning (RIC) and hematopoietic stem cell transplantation (HSCT) from matched unrelated donors. The median age was 55 yr (range 11-68) and all but 15 patients received peripheral blood stem ce...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12131

    authors: Remberger M,Ringdén O,Hägglund H,Svahn BM,Ljungman P,Uhlin M,Mattsson J

    更新日期:2013-07-01 00:00:00

  • Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

    abstract:PURPOSE:Frail patients who undergo renal transplantation (RT) have more complications; however, little is known if these patients can sustain the wait to RT. We used the Timed Up and Go Test (TUGT) and Montreal Cognitive Assessment (MoCA) to determine outcomes of RT candidates. METHODS:In this retrospective study, 526...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14161

    authors: Bozhilov K,Vo KB,Wong LL

    更新日期:2020-11-20 00:00:00

  • Incidence and clinical significance of human parvovirus B19 infection in kidney transplant recipients.

    abstract::Human parvovirus B19 (B19) infection has been known to cause chronic anemia, pure red cell aplasia (PRCA), glomerulopathy, and allograft dysfunction in kidney transplant (KT) recipients. The aim of this study was to evaluate the incidence and clinical significance of B19 infection in KT recipients. A total of 537 seru...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00415.x

    authors: Ki CS,Kim IS,Kim JW,Lee NY,Kim SH,Lee KW,Kim SJ,Joh JW,Huh WS,Oh HY

    更新日期:2005-12-01 00:00:00

  • Multidetector CT angiography in living donor renal transplantation: accuracy and discrepancies in right venous anatomy.

    abstract::Multidetector computed tomography (MDCT) angiography is a reliable technique for assessing pre-operative renal anatomy in living kidney donors. The method has largely evolved into protocols that eliminate dedicated venous phase and instead utilize a combined arterial/venous phase to delineate arterial and venous anato...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01193.x

    authors: Kulkarni S,Emre S,Arvelakis A,Asch W,Bia M,Formica R,Israel G

    更新日期:2011-01-01 00:00:00

  • Impact of the ratio of graft kidney volume to recipient body surface area on graft function after live donor kidney transplantation.

    abstract::Functioning nephron mass is a determinant of the graft function of kidney transplant recipients. The graft kidney volume and its weight have been reported to be surrogates of the nephron mass. To investigate the impact of the ratios of the surrogates to recipient body surface area (BSA) and body weight on the graft fu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01502.x

    authors: Lee JH,Won JH,Oh CK

    更新日期:2011-11-01 00:00:00

  • Conversion from sirolimus to everolimus in kidney transplant recipients receiving a calcineurin-free regimen.

    abstract:BACKGROUND:Everolimus (EVL) and sirolimus (SRL) were introduced into immunosuppressive regimens, in an attempt to replace or reduce the dose of the nephrotoxic calcineurin inhibitors (CNI). In our institution, due to an administrative decision, conversion from SRL to EVL, was carried out, providing us the opportunity t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01446.x

    authors: Carvalho C,Coentrão L,Bustorff M,Patrício E,Sampaio S,Santos J,Oliveira G,Pestana M

    更新日期:2011-07-01 00:00:00

  • Renal outcomes of simultaneous liver-kidney transplantation compared to liver transplant alone for candidates with renal dysfunction.

    abstract::It is unclear whether a concomitant kidney transplant grants survival benefit to liver transplant (LT) candidates with renal dysfunction (RD). We retrospectively studied LT candidates without RD (n = 714) and LT candidates with RD who underwent either liver transplant alone (RD-LTA; n = 103) or simultaneous liver-kidn...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12479

    authors: Brennan TV,Lunsford KE,Vagefi PA,Bostrom A,Ma M,Feng S

    更新日期:2015-01-01 00:00:00

  • Immunosuppressive standards in simultaneous kidney-pancreas transplantation.

    abstract::Simultaneous pancreas-kidney transplantation is an established procedure for patients with type I diabetes and end-stage renal disease. Continuous advances in the operation techniques with consequent reduction of perioperative morbidity and mortality and the introduction of modern immunosuppressive agents improved not...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2006.00599.x

    authors: Schmied BM,Müller SA,Mehrabi A,Welsch T,Büchler MW,Zeier M,Schmidt J

    更新日期:2006-01-01 00:00:00

  • Orthotopic liver transplantation for adult-onset type II citrullinaemia.

    abstract::Citrullinaemia is a rare autosomal recessive disorder due to a deficiency of argininosuccinate synthetase (ASS). While the clinical course of the adult onset form (Type II) is unpredictable, many patients undergo sudden deterioration with progressive cerebral oedema. Two patients with Type II citrullinaemia were refer...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Kawamoto S,Strong RW,Kerlin P,Lynch SV,Steadman C,Kobayashi K,Nakagawa S,Matsunami H,Akatsu T,Saheki T

    更新日期:1997-10-01 00:00:00

  • Quality of life assessment in renal transplant: review and future directions.

    abstract::We performed a systematic search of the literature using the MEDLINE (through 2006) database to identify the patient-reported outcome measures of quality of life (QOL) used most often in the renal transplant literature. After applying limits and reviewing references, we identified 338 renal transplant articles with a ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2007.00784.x

    authors: Butt Z,Yount SE,Caicedo JC,Abecassis MM,Cella D

    更新日期:2008-05-01 00:00:00

  • Crystalloid flush with backward unclamping may decrease post-reperfusion cardiac arrest and improve short-term graft function when compared to portal blood flush with forward unclamping during liver transplantation.

    abstract::During liver transplant (LT), the release of vasoactive substances into the systemic circulation is associated with severe hemodynamic instability that is injurious to the recipient and/or the post-ischemic graft. Crystalloid flush with backward unclamping (CB) and portal blood flush with forward unclamping (PF) are t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12130

    authors: Fukazawa K,Nishida S,Hibi T,Pretto EA Jr

    更新日期:2013-07-01 00:00:00

  • Transplantation of a severely lacerated liver--a case report with review of the literature.

    abstract::Using lacerated livers for liver transplantation (LTx) can add an option to the extended donor criteria. We present an LTx case using a severely lacerated liver and review of the literature for reported cases. We used a high-grade lacerated liver from a 19-yr-old brain-dead patient caused by traffic accident. The live...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2008.00914.x

    authors: Mehrabi A,Fonouni H,Ahmadi R,Schmied BM,Müller SA,Welsch T,Hallscheidt P,Zeier M,Weitz J,Schmidt J

    更新日期:2009-06-01 00:00:00

  • Preservation of the donor pancreas for whole pancreas and islet transplantation.

    abstract::Whole pancreas and islet cell transplantation are both reliant upon the procurement and preservation of a high quality donor pancreas for a successful outcome. In the climate of a reducing donor pool it is imperative that donor optimization, meticulous surgical retrieval and evidence based methods of preservation are ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2009.01151.x

    authors: Ridgway D,Manas D,Shaw J,White S

    更新日期:2010-01-01 00:00:00

  • Efficacy of tonsillectomy for patients with recurrence of IgA nephropathy after kidney transplantation.

    abstract::From January 2007, we started to perform the tonsillectomy for every patient with recurrent IgA nephropathy (IgAN) after kidney transplantation. Up to September 2008, four recipients with primary IgAN had biopsy-proven recurrent IgAN. They had also progressive hematuria or proteinuria from on the average 14.3 months a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01003.x

    authors: Ushigome H,Suzuki T,Fujiki M,Nobori S,Sakamoto S,Okamoto M,Urasaki K,Yoshimura N

    更新日期:2009-08-01 00:00:00

  • Changes in 6-minute walking distance in lung transplant candidates while participating in a home-based pre-habilitation program-A retrospective chart review.

    abstract::Home-based exercise programs may offer a less costly alternative to providing exercise pre-transplant to a large number of patients. We describe the changes in 6-minute walk distance (6MWD) in lung transplant candidates who participated in a home-based exercise program and their relationship to post-transplant outcome...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14045

    authors: Massierer D,Bourgeois N,Räkel A,Prévost K,Lands LC,Poirier C,Janaudis-Ferreira T

    更新日期:2020-10-01 00:00:00

  • Depletion of natural antibodies in non-human primates--a step towards successful discordant xenografting in humans.

    abstract::There is evidence to suggest that long-term survival of discordant xenografts may be possible if the organ is transplanted at a time when the host natural anti-species (xenoreactive) antibodies are temporarily absent or otherwise inhibited from reacting with the donor antigens. There is also evidence that the target ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Cooper DK

    更新日期:1992-06-01 00:00:00