Incidence and clinical significance of human parvovirus B19 infection in kidney transplant recipients.

Abstract:

:Human parvovirus B19 (B19) infection has been known to cause chronic anemia, pure red cell aplasia (PRCA), glomerulopathy, and allograft dysfunction in kidney transplant (KT) recipients. The aim of this study was to evaluate the incidence and clinical significance of B19 infection in KT recipients. A total of 537 serum samples from 167 KT recipients were included in the present study. The incidence of B19 infection was based on either qualitative polymerase chain reaction (PCR) or quantitative PCR with LightCycler Parvovirus B19 Quantitation kit. Clinical significance of B19 infection was investigated by a retrospective review of hemoglobin (Hb) levels and the results of kidney and bone marrow biopsies. The overall PCR positive rate was 18.3% (98/537), and 52 of 167 (31.1%) KT recipients showed at least one positive PCR. In addition, 20 of 167 subjects (12.0%) showed PCR-positivity more than two consecutive times, and they had significantly lower Hb levels than those with negative or one positive PCR (p < 0.0001). Furthermore, two patients suffered from PRCA, which was confirmed by bone marrow biopsy. However, B19 infection did not seem to affect the graft outcome. In conclusion, the B19 infection in KT recipients was not uncommon and was associated with low Hb levels and PRCA after KT.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Ki CS,Kim IS,Kim JW,Lee NY,Kim SH,Lee KW,Kim SJ,Joh JW,Huh WS,Oh HY

doi

10.1111/j.1399-0012.2005.00415.x

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

751-5

issue

6

eissn

0902-0063

issn

1399-0012

pii

CTR415

journal_volume

19

pub_type

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