Marijuana use should not preclude consideration for kidney transplantation.

Abstract:

:Transplant eligibility for tobacco and/or marijuana using candidates varies among transplant centers. This study compared the impact of marijuana use and tobacco use on kidney transplant recipient outcomes. Kidney transplant recipients at a single center from 2001 to 2015 were reviewed for outcomes of all-cause graft loss, infection, biopsy-proven acute rejection, and estimated glomerular filtration rate between four groups: marijuana-only users, marijuana and tobacco users, tobacco-only users, and nonusers. The cohort (N = 919) included 48 (5.2%) marijuana users, 45 (4.8%) marijuana and tobacco users, 136 (14.7%) tobacco users, and 75% nonusers. Smoking status was not significantly associated with acute rejection, estimated glomerular filtration rate or pneumonia within one-year post-transplant in an adjusted model. Compared to nonuse, marijuana and tobacco use and tobacco-only use was significantly associated with increased risk of graft loss (aHR 1.68, P = .034 and 1.52, P = .006, respectively). Patients with isolated marijuana use had similar overall graft survival compared to nonusers (aHR 1.00, P = .994). Marijuana use should not be an absolute contraindication to kidney transplant.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Fabbri KR,Anderson-Haag TL,Spenningsby AM,Israni A,Nygaard RM,Stahler PA

doi

10.1111/ctr.13706

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

e13706

issue

10

eissn

0902-0063

issn

1399-0012

journal_volume

33

pub_type

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