The significance of subclinical rejection.

Abstract:

:Subclinical rejection (SCR) is quite common early following renal transplantation and decreases progressively with time. The immunological profile of the recipient, the immunosuppressive regimen used, and the occurrence of prior episodes of clinical acute rejection (AR) are all risk factors for SCR. SCR, in turn, is a risk factor for chronic interstitial and tubular fibrosis and has been associated with worse glomerular filtration rate (GFR) and graft survival. Early SCR should be initially treated with pulse steroids. SCR is a form of biopsy-proven AR and, particularly if treated, must be fairly reported and displayed as a solid endpoint in clinical studies.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

El-Amm JM,Gruber SA

doi

10.1111/j.1399-0012.2008.00888.x

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

150-6

issue

2

eissn

0902-0063

issn

1399-0012

pii

CTR888

journal_volume

23

pub_type

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