A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus.

Abstract:

:Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of rejection. However, the blood level between its therapeutic and toxic levels is narrow such that its nephrotoxicity is a problem. Moreover, its bioavailability and pharmacokinetics are highly variable. We experienced a case of acute nephrotoxicity, in which the blood level rose about 10 times above the expected level. We found a peculiar vacuolization in the transplant biopsy specimen. This change showed a marked vacuolization of the tubular cells, suggestive of acute nephrotoxicity by TAC.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Watanabe S,Yamaguchi Y,Hattori M,Chikamoto H,Matsumoto N,Suzuki T,Oonishi M,Horita S,Tokumoto T,Tanabe K,Shiraga H,Toma H,Ito K

doi

10.1034/j.1399-0012.2000.0140s3030.x

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

30-2

eissn

0902-0063

issn

1399-0012

journal_volume

14 Suppl 3

pub_type

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