Living donor evaluation and exclusion: the Stanford experience.

Abstract:

BACKGROUND:The proportion of prospective living donors disqualified for medical reasons is unknown. The objective of this study is to delineate and quantify specific reasons for exclusion of prospective living donors from kidney donation. METHODS:All adult prospective kidney donors who contacted our transplant program between October 1, 2007 and April 1, 2009 were included in our analysis (n = 484). Data were collected by review of an electronic transplant database. RESULTS:Of the 484 prospective donors, 39 (8%) successfully donated, 229 (47%) were excluded, 104 (22%) were actively undergoing evaluation, and 112 (23%) were withdrawn before evaluation was complete. Criteria for exclusion were medical (n = 150), psychosocial (n = 22), or histocompatibility (n = 57) reasons. Of the 150 prospective donors excluded for medical reasons, 79% were excluded because of obesity, hypertension, nephrolithiasis, and/or abnormal glucose tolerance. One hundred and forty-seven (61%) intended recipients had only one prospective living donor, of whom 63 (42%) were excluded. CONCLUSIONS:A significant proportion of prospective living kidney donors were excluded for medical reasons such as obesity (body mass index >30), hypertension, nephrolithiasis, and abnormal glucose tolerance. Longer-term studies are needed to characterize the risks to medically complex kidney donors and the potential risks and benefits afforded to recipients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Lapasia JB,Kong SY,Busque S,Scandling JD,Chertow GM,Tan JC

doi

10.1111/j.1399-0012.2010.01336.x

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

697-704

issue

5

eissn

0902-0063

issn

1399-0012

journal_volume

25

pub_type

临床试验,杂志文章
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    authors: Kobashigawa JA,Itagaki BK,Razi RR,Patel JK,Chai W,Kawano MA,Goldstein Z,Kittleson MM,Fishbein MC

    更新日期:2013-11-01 00:00:00

  • Assessment of liver graft function and regeneration by galactosyl-human serum albumin (99mTc-GSA) liver scintigraphy in adult living-donor liver transplantation.

    abstract:BACKGROUND:In adult living-donor liver transplantation (LDLT), the assessment of the graft functional reserve is very important. We evaluated the graft functional reserve by technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) liver scintigraphy. PATIENTS AND METHOD:From May ...

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    authors: Iida T,Isaji S,Yagi S,Hori T,Taniguchi K,Ohsawa I,Mizuno S,Usui M,Sakurai H,Yamagiwa K,Yamakado K,Uemoto S

    更新日期:2009-03-01 00:00:00

  • Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13436

    authors: Wu JF,Muthusamy A,Al-Ghalith GA,Knights D,Guo B,Wu B,Remmel RP,Schladt DP,Alegre ML,Oetting WS,Jacobson PA,Israni AK

    更新日期:2018-12-01 00:00:00

  • Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of caution.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00828.x

    authors: Groetzner J,Kaczmarek I,Schirmer J,Uberfuhr P,Gulbins H,Daebritz S,Meiser B,Reichart B

    更新日期:2008-09-01 00:00:00

  • Effectiveness and safety of the conversion to MeltDose® extended-release tacrolimus from other formulations of tacrolimus in stable kidney transplant patients: A retrospective study.

    abstract::Tacrolimus is the cornerstone of immunosuppressive therapy after kidney transplantation. Its narrow therapeutic window mandates serum level strict monitoring and dose adjustments to ensure the optimal risk-benefit balance. This observational retrospective study analyzed the effectiveness and safety of conversion from ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13767

    authors: Sánchez Fructuoso A,Ruiz JC,Franco A,Diekmann F,Redondo D,Calviño J,Serra N,Aladrén MJ,Cigarrán S,Manonelles A,Ramos A,Gómez G,González Posada JM,Andrés A,Beneyto I,Muñiz AL,Perelló M,Lauzurica R

    更新日期:2020-01-01 00:00:00

  • Differences in perceived health status between kidney transplant recipients and dialyzed patients are based mainly on the selection process.

    abstract::Kidney transplantation offers longer survival, less morbidity and lower costs than dialysis. It is also believed to improve quality of life. The aim of this study was to compare prospectively the perceived health status (PHS) of dialyzed patients on a waiting list with kidney transplant recipients after transplantatio...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01080.x

    authors: Rosenberger J,van Dijk JP,Prihodova L,Majernikova M,Nagyova I,Geckova AM,Roland R,van den Heuvel WJ,Groothoff JW

    更新日期:2010-05-01 00:00:00

  • Adverse drug reaction driven immunosuppressive drug manipulations: a single-center comparison of enteric-coated mycophenolate sodium vs. mycophenolate mofetil.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00820.x

    authors: Hardinger KL,Hebbar S,Bloomer T,Murillo D

    更新日期:2008-09-01 00:00:00

  • Predictors of quality of life in patients evaluated for liver transplantation.

    abstract:INTRODUCTION:Health-related quality of life (HRQOL) is severely impaired in advanced liver disease. The purpose of this study was to evaluate the impact of actual liver function and disease-specific factors on HRQOL of patients evaluated for liver transplantation. PATIENTS AND METHODS:Disease-specific QOL was analyzed...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12426

    authors: Jara M,Bednarsch J,Malinowski M,Lüttgert K,Orr J,Puhl G,Seehofer D,Neuhaus P,Stockmann M

    更新日期:2014-12-01 00:00:00

  • Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12108

    authors: Vallin M,Sturm N,Lamblin G,Guillaud O,Hilleret MN,Hervieu V,Joubert J,Abergel A,Leroy V,Boillot O,Dumortier J,Scoazec JY

    更新日期:2013-05-01 00:00:00

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01214.x

    authors: Hayashi PH,Axelrod DA,Galanko J,Salvalaggio PR,Schnitzler M

    更新日期:2011-01-01 00:00:00

  • A randomized trial of thymoglobulin vs. alemtuzumab (with lower dose maintenance immunosuppression) vs. daclizumab in renal transplantation at 24 months of follow-up.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

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    authors: Ciancio G,Burke GW,Gaynor JJ,Roth D,Kupin W,Rosen A,Cordovilla T,Tueros L,Herrada E,Miller J

    更新日期:2008-03-01 00:00:00

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

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    更新日期:1999-01-01 00:00:00

  • Massive gastrointestinal hemorrhage due to rupture of a donor pancreatic artery pseudoaneurysm in a pancreas transplant patient.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00111.x

    authors: Green BT,Tuttle-Newhall J,Suhocki P,Smith SR,O'Connor JB

    更新日期:2004-02-01 00:00:00

  • Reversal of accelerated renal allograft rejection with FK 506.

    abstract::Although FK 506 has been shown to effectively reverse refractory renal allograft rejection, its ability to reverse accelerated renal allograft rejection as a primary agent has not been specifically addressed. Herein evidence of the ability of FK 506 to reverse accelerated renal allograft rejection is presented. A 16-y...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Woodle ES,Newell KA,Haas M,Bartosh S,Josephson MA,Millis JM,Bruce DS,Piper JB,Aronson AJ,Thistlethwaite JR

    更新日期:1997-08-01 00:00:00

  • Multidrug-resistant Acinetobacter baumannii infections in lung transplant patients in the cardiothoracic intensive care unit.

    abstract:BACKGROUND:Multidrug-resistant (MDR) gram-negative bacteria are a growing threat to solid organ transplantation (SOT) patients in the intensive care unit (ICU). We aimed to examine the mortality rates of gram-negative MDR bacterial infection in SOT patients compared with patient population undergoing other cardiothorac...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12575

    authors: Biderman P,Bugaevsky Y,Ben-Zvi H,Bishara J,Goldberg E

    更新日期:2015-09-01 00:00:00

  • Sequential biological immunosuppression. Induction therapy with rabbit antithymocyte globulin.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Guttmann RD,Flemming C

    更新日期:1997-06-01 00:00:00

  • Caring for the pregnant kidney transplant recipient.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2011.01492.x

    authors: Concepcion BP,Schaefer HM

    更新日期:2011-11-01 00:00:00

  • Attitudes of commercial renal transplant recipients toward renal transplantation in India.

    abstract::Renal transplantation offers patients with end-stage renal disease the best opportunity for rehabilitation and long-term survival. However, there is a critical shortage of transplantable kidneys worldwide. This plays well into the hands of transplanters and entrepreneurs involved in commercial renal transplantation, p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Qunibi W,Abulrub D,Shaheen F,el-Din AB,Alfurayh O,Almeshari K

    更新日期:1995-08-01 00:00:00

  • Depletion of natural antibodies in non-human primates--a step towards successful discordant xenografting in humans.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Cooper DK

    更新日期:1992-06-01 00:00:00

  • Association of treatment with 15-deoxyspergualin and BK virus nephropathy in kidney allograft recipients.

    abstract:OBJECTIVE:BK virus nephropathy (BKVN) has been proposed as an important cause of allograft dysfunction and loss in kidney allograft recipient over the last decade. Intense immunosuppression and tubular injury have been shown to promote the replication of polyomavirus. 15-deoxyspergualin (DSG), an effective immunosuppre...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00677.x

    authors: Shi Y,Moriyama T,Namba Y,Yamanaka M,Hanafuse T,Imamura R,Ichimaru N,Oka K,Kyo M,Tian Y,Takahara S,Ichikawa S,Okuyama A

    更新日期:2007-07-01 00:00:00

  • Late acute rejection after liver transplantation impacts patient survival.

    abstract::Hepatic allograft rejection still remains an important problem following liver transplantation. Early acute rejection, occurring within three months of transplant, is a common event and usually of lesser significance with respect to prognosis than other non-immune-related post-transplant morbidities. However, little i...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00788.x

    authors: Uemura T,Ikegami T,Sanchez EQ,Jennings LW,Narasimhan G,McKenna GJ,Randall HB,Chinnakotla S,Levy MF,Goldstein RM,Klintmalm GB

    更新日期:2008-05-01 00:00:00

  • Pancreas after living donor kidney transplants in diabetic patients: impact on long-term kidney graft function.

    abstract::In this single-institution study, we compared outcomes in diabetic recipients of living donor (LD) kidney transplants that did vs. did not undergo a subsequent pancreas transplant. Of 307 diabetic recipients who underwent LD kidney transplants from January 1, 1995, through December 31, 2003, a total of 175 underwent a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.00998.x

    authors: Kleinclauss F,Fauda M,Sutherland DE,Kleinclauss C,Gruessner RW,Matas AJ,Kasiske BL,Humar A,Kandaswamy R,Kaul S,Gruessner AC

    更新日期:2009-08-01 00:00:00

  • BK polyomavirus in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    abstract::The present AST-IDCOP guidelines update information on BK polyomavirus (BKPyV) infection, replication, and disease, which impact kidney transplantation (KT), but rarely non-kidney solid organ transplantation (SOT). As pretransplant risk factors in KT donors and recipients presently do not translate into clinically val...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13528

    authors: Hirsch HH,Randhawa PS,AST Infectious Diseases Community of Practice.

    更新日期:2019-09-01 00:00:00

  • Addition of a total pancreatectomy and pancreas transplantation in a liver transplant recipient with intraductal papillary mucinous neoplasm of the pancreas.

    abstract:BACKGROUND:Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are increasingly recognized in clinical practice. There are no published data suggesting a management approach for the potential organ transplant recipient with the incidental finding of this pre-malignant lesion. METHODS:The recipient was a 6...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00863.x

    authors: Fridell JA,Vianna R,Mangus RS,Kazimi M,Hollinger E,Joseph Tector A

    更新日期:2008-09-01 00:00:00

  • Diagnosis of hepatic allograft rejection: role of liver biopsy.

    abstract::The role of the liver biopsy for establishing a diagnosis of liver allograft rejection was investigated by examining under code 151 liver biopsies from 32 recipients and correlating the results with the clinical diagnosis determined by chart review. One-hundred-and-four biopsies were obtained to evaluate the cause of...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Aran PP,Bissel MG,Whitington PF,Bostwick DG,Adamac T,Baker AL

    更新日期:1993-10-01 00:00:00

  • Indocyanine green elimination but not bilirubin indicates improvement of graft function during MARS therapy.

    abstract::Measurement of indocyanine green plasma disappearance rate (PDR(ICG)) has been suggested as a meaningful liver function parameter. However, there are only very limited data concerning its value in the monitoring of graft dysfunction (GDF) and primary non-function (PNF) especially during molecular absorbent recirculati...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00706.x

    authors: Scheingraber S,Richter S,Igna D,Girndt M,Flesch S,Kleinschmidt S,Schilling MK

    更新日期:2007-11-01 00:00:00

  • The feared five fungal infections in kidney transplant recipients: A single-center 20-year experience.

    abstract::Invasive fungal infections are a feared complication in kidney transplant recipients (KTRs). Here we present the University of Wisconsin experience with 5 invasive fungal infections-aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, and coccidioidomycosis-in KTRs transplanted between 01/01/1994 and 06/30/20...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13289

    authors: Parajuli S,Wick A,Pandeya S,Astor BC,Smith J,Djamali A,Mandelbrot DA

    更新日期:2018-07-01 00:00:00

  • Ganciclovir exposure under a 450 mg daily dosage of valganciclovir for cytomegalovirus prevention in kidney transplantation: a prospective study.

    abstract::This prospective study aimed at determining the ganciclovir exposure observed under a daily dosage of 450 mg valganciclovir routinely applied to kidney transplant recipients with a GFR above 25 mL/min at risk for cytomegalovirus (CMV) disease. Ganciclovir levels at trough (C(trough)) and at peak (C₃(h)) were measured ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01205.x

    authors: Manuel O,Pascual M,Perrottet N,Lamoth F,Venetz JP,Decosterd LA,Buclin T,Meylan PR

    更新日期:2010-11-01 00:00:00

  • Progressive familial intrahepatic cholestasis: a single-center experience of living-donor liver transplantation during two decades in Japan.

    abstract:BACKGROUND:Progressive familial intrahepatic cholestasis (PFIC) results in liver cirrhosis. Therefore, some PFIC patients require liver transplantation (LT). Although three types of PFIC have been identified, their etiologies include unknown mechanisms. PATIENTS:A total of 717 recipients who underwent living-donor LT ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2010.01368.x

    authors: Hori T,Egawa H,Takada Y,Ueda M,Oike F,Ogura Y,Sakamoto S,Kasahara M,Ogawa K,Miyagawa-Hayashino A,Yonekawa Y,Yorifuji T,Watanabe K,Doi H,Nguyen JH,Chen F,Baine AM,Gardner LB,Uemoto S

    更新日期:2011-09-01 00:00:00

  • Outcomes of antiviral treatment in hepatitis C virus liver transplant patients off immunosuppression in the direct acting antivirals era: A case series.

    abstract:BACKGROUND:Clearance of hepatitis C virus (HCV) under antiviral therapy, including direct-acting antivirals (DAAs), has been associated with higher risk of rejection. Whether patients who are not on immunosuppression (IS) during DAA therapy are at higher risk of rejection is unknown. METHODS:Four transplant recipients...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13303

    authors: Campos-Varela I,Agudelo EZ,Terrault NA

    更新日期:2018-07-01 00:00:00