Addition of a total pancreatectomy and pancreas transplantation in a liver transplant recipient with intraductal papillary mucinous neoplasm of the pancreas.

Abstract:

BACKGROUND:Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are increasingly recognized in clinical practice. There are no published data suggesting a management approach for the potential organ transplant recipient with the incidental finding of this pre-malignant lesion. METHODS:The recipient was a 65-yr-old man with hepatocellular carcinoma in a background of Laennec's cirrhosis. During evaluation for transplant, he was found to have diffuse IPMN. This patient underwent liver transplantation with a planned simultaneous total native pancreatectomy and pancreas transplant from the same donor. RESULTS:The patient has had normal liver function and has been free of diabetes and exocrine insufficiency at 18 months post-transplant. CONCLUSION:IPMN in the potential transplant recipient should be managed more aggressively than in the general population because these patients will be committed to life-long immunosuppression. If a total pancreatectomy is contemplated, this is a unique opportunity to replace the pancreas with an allograft at the time of transplantation.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Fridell JA,Vianna R,Mangus RS,Kazimi M,Hollinger E,Joseph Tector A

doi

10.1111/j.1399-0012.2008.00863.x

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

681-4

issue

5

eissn

0902-0063

issn

1399-0012

pii

CTR863

journal_volume

22

pub_type

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