Improving graft survival for patients undergoing liver transplantation.

Abstract:

:Liver transplant (LT) outcomes are reported to be improving in non-HCV recipients but not for those infected with HCV. Our aim was to evaluate graft survival and predictors of outcome in HCV and non-HCV patients before and after 2003. Patients with primary LT between February 1, 1998, and December 31, 2005, were included. Patients were divided into Era 1 (1998-2002) and Era 2 (2003-2005) with follow-up through May 31, 2009. Graft survival was compared for HCV, non-HCV, and all patients. There was significant improvement in graft survival in Era 2 for HCV patients. Graft survival in Era 2 of HCV patients was equivalent to non-HCV patients. The most significant improvement between eras was in outcomes of grafts from donors ≥60 yr with three-yr graft survival 58.6 (51.3-65.9) vs. 75.4 (68.9-81.9), p = 0.002. The use of donors ≥60 did not change between eras: 31% vs. 34%; however, utilization in HCV recipients decreased from 36% to 3% (p < 0.001). In conclusion, graft survival of HCV patients has improved significantly since 2003 and was comparable to non-HCV patients up to three yr. The change in management of donor organs into HCV and non-HCV patients likely contributed to this outcome.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Dickson RC,Pungpapong S,Keaveny AP,Taner CB,Ghabril M,Aranda-Michel J,Satyanarayana R,Bonatti H,Kramer DJ,Nguyen JH

doi

10.1111/j.1399-0012.2011.01428.x

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

E345-55

issue

3

eissn

0902-0063

issn

1399-0012

journal_volume

25

pub_type

杂志文章
  • Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation.

    abstract::We sought to determine the incidence, risk factors, and consequences of acute rejection (AR) after conversion from a calcineurin inhibitor (CNI) to a proliferation signal inhibitor (PSI) in maintenance heart transplantation. Relevant clinical data were retrospectively obtained for 284 long-term heart transplant recipi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.12241

    authors: González-Vílchez F,Vázquez de Prada JA,Paniagua MJ,Almenar L,Mirabet S,Gómez-Bueno M,Díaz-Molina B,Arizón JM,Delgado J,Pérez-Villa F,Crespo-Leiro MG,Martínez-Dolz L,Roig E,Segovia J,Lambert JL,Lopez-Granados A,Escribano P

    更新日期:2013-11-01 00:00:00

  • The clinical characteristics, pre- and post-liver transplantation outcomes in patients having autoimmune overlap syndromes.

    abstract:BACKGROUND:There are little data on the pre- and post-liver transplantation (LT) outcomes of patients having autoimmune hepatitis-primary biliary cholangitis (AIH-PBC), AIH-primary sclerosing cholangitis (AIH-PSC), and AIH-small-duct PSC (AIH-SDPSC). The aim of this study was to analyze pre- and post-LT outcomes and su...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13841

    authors: Chayanupatkul M,Fiel MI,Schiano TD

    更新日期:2020-05-01 00:00:00

  • Increased risk of post-transplant diabetes mellitus despite early steroid discontinuation in Hispanic kidney transplant recipients.

    abstract::Early steroid discontinuation (ESD) has been associated with a lower incidence of post-transplant diabetes mellitus (PTDM). We retrospectively reviewed the incidence of PTDM in relation to racial groups in kidney transplant recipients treated with ESD. Between January 2002 and September 2003, 125 consecutive primary a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00383.x

    authors: Walczak DA,Calvert D,Jarzembowski TM,Testa G,Sankary HN,Thielke J,Oberholzer J,Benedetti E

    更新日期:2005-08-01 00:00:00

  • Renal transplantation in systemic amyloidosis.

    abstract::Renal transplantation was performed in a 24-yr-old woman with type AA systemic amyloidosis. Renal biopsy at 11 yr post-transplantation showed no amyloid recurrence, but the presence of mesangial proliferative glomerulonephritis and focal segmental glomerular sclerosis. Renal function was satisfactory with the exceptio...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Nishikido M,Koga S,Kanetake H,Saito Y,Harada T,Taguchi T,Matsuya F,Shindo K

    更新日期:1999-01-01 00:00:00

  • Foot problems in the diabetic transplant recipient.

    abstract::Diabetic transplant recipients are at a high risk for foot pathology leading to amputation. This retrospective study from 1/85 to 2/95 examines the risk of foot complications in a population (n = 340) of diabetic renal and combined renal/pancreas transplant recipients. All groups suffered high lower extremity amputati...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Kalker AJ,Pirsch JD,Heisey D,Sollinger HW,Belzer FO,Knechtle SJ,D'Alessandro AM

    更新日期:1996-12-01 00:00:00

  • Attitude toward xenotransplantation of patients prior and after human organ transplantation.

    abstract::Xenotransplantation is a potential strategy to overcome the shortage of human donor organs. As this technique has a major medical and psychological impact on patients and their family and friends, the attitude of patients currently waiting for organ transplantation is important. Therefore, we conducted a survey on the...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01296.x

    authors: Stadlbauer V,Stiegler P,Müller S,Schweiger M,Sereingg M,Tscheliessnigg KH,Freidl W

    更新日期:2011-05-01 00:00:00

  • Feasibility of exercise stress echocardiography for cardiac risk assessment in chronic kidney disease patients prior to renal transplantation.

    abstract:BACKGROUND:Pharmacologic stress testing is utilized in preference to exercise stress echocardiography (ESE) for cardiac risk evaluation in potential renal transplant recipients due to the perceived lower feasibility of ESE for achieving adequate workload and target heart rate (THR) in this population. METHODS:Consecut...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12796

    authors: Nerlekar N,Mulley W,Rehmani H,Ramkumar S,Cheng K,Vasanthakumar SA,Rashid H,Barton T,Nasis A,Meredith IT,Moir S,Mottram PM

    更新日期:2016-10-01 00:00:00

  • Histoplasmosis in transplant recipients.

    abstract::Histoplasma capsulatum is a dimorphic fungus that most often causes asymptomatic infection in the immunocompetent population. In immunocompromised patients, including solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, however, it is likely to cause severe life-threatening infection. Post-...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.13087

    authors: Gajurel K,Dhakal R,Deresinski S

    更新日期:2017-10-01 00:00:00

  • Peritoneal metastasis of intracranial glioblastoma via a ventriculoperitoneal shunt preventing organ retrieval: case report and review of the literature.

    abstract::The case of patient with glioblastoma metastatic to the peritoneal cavity 9 months after ventriculoperitoneal shunt surgery precluding cadaver organ procurement is presented. Even though central nervous tumors rarely metastasize spontaneously, the literature indicates that systemic metastases are related to previous s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Fecteau AH,Penn I,Hanto DW

    更新日期:1998-08-01 00:00:00

  • The role of biomechanical anatomical modeling via computed tomography for identification of restrictive allograft syndrome.

    abstract::Chronic lung allograft dysfunction (CLAD) reduces long-term graft survival. It is important to distinguish CLAD subtypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS) as RAS has a worse prognosis and accurate subtyping could facilitate targeted treatments. However, the current diagn...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13027

    authors: Horie M,Saito T,Moseley J,D'Errico L,Salazar P,Nakajima D,Brock K,Yasufuku K,Binnie M,Keshavjee S,Paul N

    更新日期:2017-08-01 00:00:00

  • Low birthweight and risk of albuminuria in living kidney donors.

    abstract::Low birthweight is linked to hypertension, chronic kidney disease and even end-stage renal disease. We hypothesized that living kidney donors born with lower birthweight may be at increased risk of hypertension, albuminuria, or reduced GFR beyond what is typical following uninephrectomy. Two hundred fifty-seven living...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12321

    authors: Berglund D,MacDonald D,Jackson S,Spong R,Issa N,Kukla A,Reule S,Weber M,Matas AJ,Ibrahim HN

    更新日期:2014-03-01 00:00:00

  • Diagnosis of kidney transplant obstruction using Mag3 diuretic renography.

    abstract::Kidney transplant obstruction (KTO) following renal transplantation remains an important reversible cause of allograft dysfunction, requiring prompt diagnosis to prevent long-term graft damage. Although ultrasound can accurately diagnose renal transplant hydronephrosis, it cannot be used to assess its functional signi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150103.x

    authors: Nankivell BJ,Cohn DA,Spicer ST,Evans SG,Chapman JR,Gruenewald SM

    更新日期:2001-02-01 00:00:00

  • Plasma mycophenolic acid concentration and the clinical outcome after lung transplantation.

    abstract:BACKGROUND:The therapeutic drug monitoring of mycophenolic acid (MPA) has been investigated for renal and heart transplantations; however, its usefulness in lung transplantation is unclear. METHODS:The MPA area under the plasma concentration-time curve (AUC) was calculated in 59 adult lung transplant recipients. The M...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14088

    authors: Yabuki H,Matsuda Y,Watanabe T,Eba S,Hoshi F,Hirama T,Oishi H,Sado T,Noda M,Sakurada A,Kikuchi M,Yamaguchi H,Mano N,Okada Y

    更新日期:2020-12-01 00:00:00

  • Orthotopic liver transplantation for adult-onset type II citrullinaemia.

    abstract::Citrullinaemia is a rare autosomal recessive disorder due to a deficiency of argininosuccinate synthetase (ASS). While the clinical course of the adult onset form (Type II) is unpredictable, many patients undergo sudden deterioration with progressive cerebral oedema. Two patients with Type II citrullinaemia were refer...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Kawamoto S,Strong RW,Kerlin P,Lynch SV,Steadman C,Kobayashi K,Nakagawa S,Matsunami H,Akatsu T,Saheki T

    更新日期:1997-10-01 00:00:00

  • Orthotopic placement of a segmental pancreas graft for transplant: a case report.

    abstract::Pancreas retransplantation has become more frequent and represents a technical challenge for surgeons. Knowledge of alternative surgical options could be useful in difficult cases. We present a case of brutal diabetes mellitus in a patient with severe vascular disease that underwent a third pancreas transplant. Diffic...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01149.x

    authors: Garcia-Roca R,Humar A,Sturdevant M,Kobayashi T,Dunn T,Kandaswamy R,Sutherland D

    更新日期:2010-05-01 00:00:00

  • A new approach to kidney wait-list management in the kidney allocation system era: Pilot implementation and evaluation.

    abstract::Kidney transplant wait-list management is becoming increasingly complex. We introduced a novel wait-list management strategy at our center, the Transplant Readiness Assessment Clinic (TRAC), whereby patients whose Kidney Allocation Scores surpass a threshold are actively managed. From January 1, 2016 through June 30, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13406

    authors: Cheng XS,Busque S,Lee J,Discipulo K,Hartley C,Tulu Z,Scandling JD,Tan JC

    更新日期:2018-11-01 00:00:00

  • Perspectives on donor lung allocation from both sides of the Atlantic: The United States.

    abstract::Donor lung allocation in the United States focuses on decreasing waitlist mortality and improving recipient outcomes. The implementation of allocation policy to match deceased donor lungs to waitlisted patients occurs through a unique partnership between government and private organizations, namely the Organ Procureme...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13873

    authors: Tsuang WM,Snyder LD,Budev MM

    更新日期:2020-07-01 00:00:00

  • Importance of bone marrow cell dose in bone marrow transplantation.

    abstract::The importance of the size of the infused marrow cell dose (MCD) was investigated in 274 patients undergoing allogeneic BMT between 1975 and 1990. Among those, 65 had acute myelogenous leukemia (AML), 79 acute lymphoblastic leukemia (ALL), 58 chronic myelogenous leukemia (CML) and 25 severe aplastic anemia (SAA). MC...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Paulin T

    更新日期:1992-02-01 00:00:00

  • Donor CD163 and nestin-positive cells predict graft function in living donor liver transplant.

    abstract:AIMS:To evaluate the effect of donor liver resident mesenchymal cells, M2 macrophages on liver graft outcome after living donor liver transplantation. MATERIALS AND METHODS:Seventy donor biopsies were included in the study. Outcomes at day 3, 7, 30, and 180 postliver transplantation were assessed. Mesenchymal stem cel...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13197

    authors: Nigam N,Bihari C,Lal D,Rastogi A,Kumar S,Pamecha V,Kaur S,Kumar A,Sarin SK

    更新日期:2018-03-01 00:00:00

  • SDF-1 expression is elevated in chronic human renal allograft rejection.

    abstract::The exact mechanism of acute and chronic allograft rejection still remains unclear. The chemokine SDF-1 as mediator of allograft rejection has been under intensive investigation in liver, cardiac and bone marrow transplantation, whereas in renal transplantation, there are no reports about SDF-1 to date. This study was...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00540.x

    authors: Hoffmann U,Banas B,Krüger B,Banas M,Bergler T,Böger C,Kammerl M,Obed A,Rümmele P,Segerer S,Riegger GA,Krämer BK

    更新日期:2006-11-01 00:00:00

  • LabMELD-based organ allocation increases total costs of liver transplantation: a single-center experience.

    abstract:INTRODUCTION:In 2006, model for end-stage liver disease (MELD)-based allocation was implemented in the Eurotransplant (ET) region. Sick patients, who in general require more resources, are prioritized. In this analysis, the effect of MELD on costs for liver transplantation (LTx) was assessed. METHODS:Total costs for L...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2011.01483.x

    authors: Bruns H,Hillebrand N,Schneider T,Hinz U,Fischer L,Schmidt J,Goldschmidt AJ,Schemmer P

    更新日期:2011-09-01 00:00:00

  • Use of G-CSF-stimulated marrow in allogeneic hematopoietic stem cell transplantation settings: a comprehensive review.

    abstract::In recent years, several researchers have unraveled the previously unrecognized effects of granulocyte colony-stimulating factor (G-CSF) on hematopoiesis and the immune cell functions of bone marrow in healthy donors. In human leukocyte antigen-matched or haploidentical transplant settings, available data have establi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2010.01298.x

    authors: Chang YJ,Huang XJ

    更新日期:2011-01-01 00:00:00

  • Mast cell phenotypes in the allograft after lung transplantation.

    abstract:BACKGROUND:The burden of mast cell (MC) infiltration and their phenotypes, MC-tryptase (MCT ) and MC-tryptase/chymase (MCTC ), after lung transplantation (LT) has not been evaluated in human studies. METHODS:We reviewed 20 transbronchial lung biopsy (TBLB) specimen from patients with early normal allograft (<6 months ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12758

    authors: Banga A,Han Y,Wang X,Hsieh FH

    更新日期:2016-07-01 00:00:00

  • A calcineurin antagonist-free induction/maintenance strategy for immunosuppression in elderly recipients of renal allografts from elderly cadaver donors: long-term results from a prospective single centre trial.

    abstract:BACKGROUND:With the aim to improve the inferior outcomes in elderly recipients of kidneys from elderly cadaver donors, we applied and investigated a therapeutic regimen consisting of calcineurin inhibitor (CNI)-free, mycophenolate mofetil (MMF)-based immunosuppressive (i.s.) induction/maintenance protocol. In this arti...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2005.00309.x

    authors: Arbogast H,Hückelheim H,Schneeberger H,Illner WD,Tarabichi A,Fertmann J,Wimmer CD,Hillebrand GF,Mistry-Burchardi N,Thomae R,Acikgöz A,Land W

    更新日期:2005-06-01 00:00:00

  • Histological features of renal allograft biopsies in ABO minor-mismatched kidney transplantation.

    abstract::We examined histological features of allograft biopsies in ABO minor-mismatched kidney transplantation. Forty-five patients who underwent ABO minor-mismatched kidney transplantation between September 1999 and December 2001 at our institute. The mean age was 32.6 years, with 28 males and 17 females. We divided them int...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.17.s10.1.x

    authors: Shimizu T,Tanabe K,Tokumoto T,Shimmura H,Ishikawa N,Ishida H,Toma H,Kawaguchi H,Tokiwa M,Yamaguchi Y

    更新日期:2003-01-01 00:00:00

  • Is Pneumocystis carinii pneumonia after stem cell transplantations a contagious disease?

    abstract::We report of twins who underwent hematopoietic stem cell transplantation (HSCT) for neonatal acute leukemia. Hospitalized in the same room from the time the first one demonstrated respiratory symptoms, they both developed Pneumocystis jiroveci (formerly carinii) pneumonia (PCP) 2 wk apart. This observation suggests th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00346.x

    authors: Resnick IB,Averbuch D,Aker M,Engelhard D

    更新日期:2005-06-01 00:00:00

  • Coronary artery disease in lung transplant patients.

    abstract::Coronary artery disease (CAD) is a pathology often found in patients with end-stage lung disease. Although in the past CAD might have been considered an absolute contraindication, modern revascularization techniques have helped increase the number of transplants performed in this population. However, discrepancies in ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.14078

    authors: Sinha N,Balayla G,Braghiroli J

    更新日期:2020-11-01 00:00:00

  • The impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes.

    abstract:BACKGROUND:Intraoperative fluid management during laparoscopic donor nephrectomy (LDN) may have a significant effect on donor and recipient outcomes. We sought to quantify variability in fluid management and investigate its impact on donor and recipient outcomes. METHODS:A retrospective review of patients who underwen...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13542

    authors: Williams AM,Kumar SS,Bhatti UF,Biesterveld BE,Kathawate RG,Sung RS,Woodside KJ,Englesbe MJ,Alameddine MB,Waits SA

    更新日期:2019-06-01 00:00:00

  • Association of treatment with 15-deoxyspergualin and BK virus nephropathy in kidney allograft recipients.

    abstract:OBJECTIVE:BK virus nephropathy (BKVN) has been proposed as an important cause of allograft dysfunction and loss in kidney allograft recipient over the last decade. Intense immunosuppression and tubular injury have been shown to promote the replication of polyomavirus. 15-deoxyspergualin (DSG), an effective immunosuppre...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00677.x

    authors: Shi Y,Moriyama T,Namba Y,Yamanaka M,Hanafuse T,Imamura R,Ichimaru N,Oka K,Kyo M,Tian Y,Takahara S,Ichikawa S,Okuyama A

    更新日期:2007-07-01 00:00:00

  • Atelectasis--an unusual and late complication of lung transplant.

    abstract::We report a previously unrecognized late complication of allograft lung transplantation - persistent recurrent atelectasis of the transplanted lung. The patient developed sudden, severe respiratory distress about 2 yr after a right lung transplant, because of acute atelectasis of her transplanted lung. Multiple transb...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.01121.x

    authors: Zhao Y,Al-Kaade S,Keller CA,deMello DE

    更新日期:2002-06-01 00:00:00