The clinical characteristics, pre- and post-liver transplantation outcomes in patients having autoimmune overlap syndromes.

Abstract:

BACKGROUND:There are little data on the pre- and post-liver transplantation (LT) outcomes of patients having autoimmune hepatitis-primary biliary cholangitis (AIH-PBC), AIH-primary sclerosing cholangitis (AIH-PSC), and AIH-small-duct PSC (AIH-SDPSC). The aim of this study was to analyze pre- and post-LT outcomes and survival of patients having different overlap syndromes (OS) undergoing LT. METHODS:Patients with compatible clinical and pathologic features of AIH-PBC (n = 86), AIH-PSC (n = 22), and AIH-SDPSC (n = 9) were included in the study. Demographic, laboratory, clinical, and survival data were analyzed. Multivariable analyses were performed to determine factors predicting transplant-free survival. RESULTS:AIH-primary sclerosing cholangitis patients were less treatment-responsive and were more likely to undergo LT than other OS. No survival difference was noted among the 3 groups. Liver decompensation was independently associated with higher mortality (HR 21.78; 95% CI 2.50-190.01). Thirteen patients with OS underwent LT. One-year survival post-LT was 91.7%. Overall recurrence rate for OS post-LT was 8%. CONCLUSIONS:AIH-primary sclerosing cholangitis patients were more likely to require LT compared with patients having AIH-PBC. Transplant-free survival was similar among the three AIH-overlap syndromes. Allograft recurrence of OS occurred in about 10% of cases. Patients with OS appear to have good short- and medium-term post-LT outcomes in terms of graft function and overall survival.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Chayanupatkul M,Fiel MI,Schiano TD

doi

10.1111/ctr.13841

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

e13841

issue

5

eissn

0902-0063

issn

1399-0012

journal_volume

34

pub_type

杂志文章
  • Non-invasive ventilation in prone position for refractory hypoxemia after bilateral lung transplantation.

    abstract::Temporary graft dysfunction with gas exchange abnormalities is a common finding during the postoperative course of a lung transplant and is often determined by the post-reimplantation syndrome. Supportive measures including oxygen by mask, inotropes, diuretics, and pulmonary vasodilators are usually effective in non-s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01050.x

    authors: Feltracco P,Serra E,Barbieri S,Persona P,Rea F,Loy M,Ori C

    更新日期:2009-09-01 00:00:00

  • Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy.

    abstract::We investigated tolerability and efficacy of ezetimibe treatment (10 mg/d) in 25 heart allograft recipients already on stable statin therapy. Total cholesterol (TC), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C), triglycerides (TG), immunosuppressant drug levels, laboratory and clinical parameters ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2008.00838.x

    authors: Konstandin MH,Blessing E,Doesch A,Ammon K,Koch A,Wabnitz GH,Gleissner CA,Remppis A,Katus HA,Dengler TJ

    更新日期:2008-09-01 00:00:00

  • Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants.

    abstract::Liver cirrhosis is a recognized risk factor for intrahepatic cholangiocarcinoma (I-CCa). Small I-CCa nodules might be undiagnosed or misdiagnosed as hepatocellular carcinoma (HCC) in the context of liver cirrhosis. The aim of this study was to determine the prevalence and clinical impact of undetected I-CCa in liver e...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12108

    authors: Vallin M,Sturm N,Lamblin G,Guillaud O,Hilleret MN,Hervieu V,Joubert J,Abergel A,Leroy V,Boillot O,Dumortier J,Scoazec JY

    更新日期:2013-05-01 00:00:00

  • The effect of calcineurin inhibitors on endothelial function in renal transplant recipients.

    abstract::Endothelial dysfunction is of vital importance, as it may cause ischemia and dysfunction in various organs. Despite, this problem has been well documented in patients with end-stage renal disease (ESRD), there is not enough data considering this issue following renal transplantation. One of the potential causes of end...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.00030.x

    authors: Oflaz H,Turkmen A,Kazancioglu R,Kayacan SM,Bunyak B,Genchallac H,Erol B,Mercanoglu F,Umman S,Sever MS

    更新日期:2003-06-01 00:00:00

  • Cell-mediated xenoresponses: strong or weak?

    abstract::Cell-mediated responses to xenoantigens are different from those to alloantigens. CD4+ T cells are especially important in xenoresponses and depletion of CD4+ T cells can prolong survival of xenografts better than allografts in some circumstances. The difference between the two responses is due in part to the relative...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Auchincloss H Jr

    更新日期:1994-04-01 00:00:00

  • Extracorporeal membrane oxygenation as a bridge vs. non-bridging for lung transplantation: A systematic review and meta-analysis.

    abstract::Whether extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation (BTT) can achieve a similar survival to non-BTT remains controversial. We conducted this meta-analysis to compare the outcomes between ECMO BTT and non-BTT to facilitate better clinical decision-making. Seven databases were searched...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14157

    authors: Wan X,Bian T,Ye S,Cai P,Yu Z,Zhu J,Zhang W

    更新日期:2020-11-22 00:00:00

  • Kidney graft survival in patients with hepatitis C: a single center experience.

    abstract::Hepatitis C virus (HCV) infection is highly prevalent in renal transplant candidates; however, its effect on the transplant outcome is still controversial. The aim of the present study was to determine the effect of HCV infection in the outcome of kidney transplantation in a single transplant center. The study populat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00679.x

    authors: Arango J,Arbelaez M,Henao J,Mejia G,Arroyave I,Carvajal J,Garcia A,Gutierrez J,Velásquez A,Garcia L,Aguirre C

    更新日期:2008-01-01 00:00:00

  • Steroid-related complications in the cyclosporine era.

    abstract::Steroid withdrawal has potential risks (rejection) and benefits (fewer complications). Most data on steroid-related complications predates cyclosporine (CsA). We tabulated the incidence of posttransplant complications considered to be steroid-related in 748 adult kidney transplant recipients (with at least 1 year of f...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Fryer JP,Granger DK,Leventhal JR,Gillingham K,Najarian JS,Matas AJ

    更新日期:1994-06-01 00:00:00

  • Differential gene expression in non-adherent heart transplant survivors: Implications for regulatory T-cell expression.

    abstract::Survival despite prolonged non-adherence with immunosuppression is rare but has been reported in kidney, lung, and liver transplantation. Its occurrence in heart transplantation is quite rare. Our study was prompted by an index patient who survived despite prolonged medication non-adherence. Prospective consent and bl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13834

    authors: Baran DA,Rao P,Deo D,Zucker MJ

    更新日期:2020-05-01 00:00:00

  • Outcomes, complications, and economic impact of ABO-incompatible living kidney transplantation: A single-center Japanese cohort study.

    abstract::ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-t...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13591

    authors: Kakuta Y,Okumi M,Unagami K,Iizuka J,Takagi T,Ishida H,Tanabe K

    更新日期:2019-06-01 00:00:00

  • Epidemiology, risk factors, and impact of bacterial infections on outcomes for pancreatic grafts.

    abstract::We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial in...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13333

    authors: Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

    更新日期:2018-08-01 00:00:00

  • Monitoring changes in cyclosporine dosage by trough level testing.

    abstract::The concept of a narrow therapeutic window has guided the management of transplant recipients on cyclosporine immunosuppression since its inception more than a decade ago. The need to maintain immunosuppression and avoid toxicity imposed the requirement of monitoring cyclosporine levels within a limited range. The use...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Takasugi M,Takasugi JK,Barba L

    更新日期:1995-04-01 00:00:00

  • Anemia following renal transplantation: erythropoietin response and iron deficiency.

    abstract::To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Miles AM,Markell MS,Daskalakis P,Sumrani NB,Hong J,Sommer BG,Friedman EA

    更新日期:1997-08-01 00:00:00

  • The significance of subclinical rejection.

    abstract::Subclinical rejection (SCR) is quite common early following renal transplantation and decreases progressively with time. The immunological profile of the recipient, the immunosuppressive regimen used, and the occurrence of prior episodes of clinical acute rejection (AR) are all risk factors for SCR. SCR, in turn, is a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2008.00888.x

    authors: El-Amm JM,Gruber SA

    更新日期:2009-03-01 00:00:00

  • Cardiovascular complications following liver transplantation.

    abstract:BACKGROUND:As the indications for liver transplantation broaden to include older and more critically ill patients, the likelihood of encountering unsuspected cardiovascular disease increases. PURPOSE:This study examined the frequency, type, and subsequent outcome of intra- and postoperative cardiovascular complication...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Dec GW,Kondo N,Farrell ML,Dienstag J,Cosimi AB,Semigran MJ

    更新日期:1995-12-01 00:00:00

  • Chronic allograft nephropathy--a clinical syndrome: early detection and the potential role of proliferation signal inhibitors.

    abstract::Chronic allograft nephropathy (CAN) leads to the majority of late graft loss following renal transplantation. Detection of CAN is often too late to permit early intervention and successful management. Most current strategies for managing CAN rely on minimizing or eliminating calcineurin inhibitors (CNIs) once CAN has ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2009.01057.x

    authors: Campistol JM,Boletis IN,Dantal J,de Fijter JW,Hertig A,Neumayer HH,Oyen O,Pascual J,Pohanka E,Ruiz JC,Scolari MP,Stefoni S,Serón D,Sparacino V,Arns W,Chapman JR

    更新日期:2009-11-01 00:00:00

  • How does age affect the outcome of kidney transplantation in elderly recipients?

    abstract::The aging of the on-dialysis population raises the issue of whether to propose elderly patients for kidney transplantation and how to manage their immunosuppression. This study aimed to analyze the outcome of kidney transplantation on an Italian series of elderly recipients. We included in this retrospective study all...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13036

    authors: Neri F,Furian L,Cavallin F,Ravaioli M,Silvestre C,Donato P,La Manna G,Pinna AD,Rigotti P

    更新日期:2017-10-01 00:00:00

  • Effect of storage temperature on early graft function following liver transplantation.

    abstract::The effect of storage temperature on early graft function following liver transplantation was investigated by analyzing the results following transplantation during three periods in which different techniques for graft storage were used. The techniques involved ice-packing (period 1), storage in a standard operating ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Morino M,Adam R,Diamond T,Castaing D,Reynes M,Bismuth H

    更新日期:1992-04-01 00:00:00

  • Risk factors for acute rejection in renal transplant recipients experiencing delayed graft function.

    abstract::Acute rejection (AR) superimposed upon delayed graft function (DGF) following renal transplantation worsens graft outcomes. However, risk factors for AR in patients displaying DGF remain unclear. In this study, 71 patients displaying DGF >/= 5 d were investigated. All received cyclosporine, adjunctive azathioprine or ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00837.x

    authors: Moore J,Tan K,Cockwell P,Krishnan H,McPake D,Ready A,Mellor S,Hamsho A,Ball S,Lipkin G,Borrows R

    更新日期:2008-09-01 00:00:00

  • Urinary tract infections after renal transplantation: a retrospective review at two US transplant centers.

    abstract::Urinary tract infections (UTIs) are the most common infectious complication following renal transplantation. Previous studies uniformly report that renal transplant recipients develop UTIs more often than the general population, but widely differ on how frequently UTIs occur after transplantation. These studies also d...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00327.x

    authors: Chuang P,Parikh CR,Langone A

    更新日期:2005-04-01 00:00:00

  • Pancreas after living donor kidney transplants in diabetic patients: impact on long-term kidney graft function.

    abstract::In this single-institution study, we compared outcomes in diabetic recipients of living donor (LD) kidney transplants that did vs. did not undergo a subsequent pancreas transplant. Of 307 diabetic recipients who underwent LD kidney transplants from January 1, 1995, through December 31, 2003, a total of 175 underwent a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.00998.x

    authors: Kleinclauss F,Fauda M,Sutherland DE,Kleinclauss C,Gruessner RW,Matas AJ,Kasiske BL,Humar A,Kandaswamy R,Kaul S,Gruessner AC

    更新日期:2009-08-01 00:00:00

  • High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.

    abstract::The non-relapse mortality of autologous stem cell transplant is low enough that the procedure has been extended to older patients with non-Hodgkin's lymphoma. We treated 537 non-Hodgkin's lymphoma patients with high-dose chemotherapy consisting of busulfan, cyclophosphamide, and etoposide followed by autologous stem c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00581.x

    authors: Kalaycio M,Pohlman B,Kuczkowski E,Rybicki L,Andresen S,Sobecks R,Bolwell B

    更新日期:2006-11-01 00:00:00

  • Laparoscopic donor nephrectomy - safety in a small-volume transplant center.

    abstract:INTRODUCTION:Laparoscopy is a standard surgical option for live donor nephrectomy (LDN) at the majority of transplant centers. Equivalent graft survival with shorter convalescence has been reported by several large volume centers. With the arrival of an experienced laparoscopic surgeon in 2002, we began to offer laparo...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01153.x

    authors: Riley J,Troxel S,Wakefield M,Ross G,Weinstein S

    更新日期:2010-05-01 00:00:00

  • Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study.

    abstract:BACKGROUND:Stem cell-based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)-derived stromal cells in post-HCV liver cirrhosis patients. METHODOLOGY:10 × 10(6) of isolated huma...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12179

    authors: Amin MA,Sabry D,Rashed LA,Aref WM,el-Ghobary MA,Farhan MS,Fouad HA,Youssef YA

    更新日期:2013-07-01 00:00:00

  • Current principles and practice in autologous intraportal islet transplantation: a meta-analysis of the technical considerations.

    abstract:OBJECTIVES:Autologous islet transplantation (IAT) following pancreatectomy is now a recognized, albeit highly specialized procedure carried out in a small number of centers worldwide. Current clinical principles and best practice with emphasis on examining the technical aspects of surgery in centers with significant IA...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ctr.12695

    authors: Kumar R,Chung WY,Dennison AR,Garcea G

    更新日期:2016-04-01 00:00:00

  • Differential gene expression pattern in biopsies with renal allograft pyelonephritis and allograft rejection.

    abstract::Differentiating acute pyelonephritis (APN) from acute rejection (AR) in renal allograft biopsies can sometimes be difficult because of overlapping clinical and histologic features, lack of positive urine cultures,and variable response to antibiotics. We wanted to study differential gene expression between AR and APN u...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12795

    authors: Oghumu S,Nori U,Bracewell A,Zhang J,Bott C,Nadasdy GM,Brodsky SV,Pelletier R,Satoskar AR,Nadasdy T,Satoskar AA

    更新日期:2016-09-01 00:00:00

  • Evolution of body weight parameters up to 3 years after solid organ transplantation: The prospective Swiss Transplant Cohort Study.

    abstract::Obesity and weight gain are serious concerns after solid organ transplantation (Tx); however, no unbiased comparison regarding body weight parameter evolution across organ groups has yet been performed. Using data from the prospective nationwide Swiss Transplant Cohort Study, we compared the evolution of weight parame...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12896

    authors: Beckmann S,Nikolic N,Denhaerynck K,Binet I,Koller M,Boely E,De Geest S,Psychosocial Interest Group, Swiss Transplant Cohort Study.

    更新日期:2017-03-01 00:00:00

  • A case of living-related renal transplant from the donor with membranous nephropathy.

    abstract:INTRODUCTION:When a patient who had renal replacement therapy becomes older, an elder donor candidate may be considered as a potential donor for living-related transplantation. Elder donor candidate might have pre-existing disease including mild renal dysfunction, such as proteinuria. Marginally appropriate donors migh...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.00999.x

    authors: Akioka K,Okamoto M,Ushigome H,Nobori S,Suzuki T,Sakai K,Sakamoto S,Urasaki K,Yanagisawa A,Fukatsu A,Yoshimura N

    更新日期:2009-08-01 00:00:00

  • Post-transplant lymphoproliferative disorders: clinicopathological analysis of 43 cases in a single center, 1990-2009.

    abstract::Post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous set of complications of organ transplantation associated with poor patient prognosis. We analyzed the clinicopathological features of PTLDs in 43 adult and pediatric recipients of solid organ or bone marrow transplantation at a large transplant ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2010.01392.x

    authors: Yoon SO,Yu E,Cho YM,Suh C,Kim KM,Han DJ,Lee SG,Huh J

    更新日期:2012-01-01 00:00:00

  • Crystalloid flush with backward unclamping may decrease post-reperfusion cardiac arrest and improve short-term graft function when compared to portal blood flush with forward unclamping during liver transplantation.

    abstract::During liver transplant (LT), the release of vasoactive substances into the systemic circulation is associated with severe hemodynamic instability that is injurious to the recipient and/or the post-ischemic graft. Crystalloid flush with backward unclamping (CB) and portal blood flush with forward unclamping (PF) are t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12130

    authors: Fukazawa K,Nishida S,Hibi T,Pretto EA Jr

    更新日期:2013-07-01 00:00:00